The main focus of the Molecular Biology Division is to understand the regulation of basic and disease related cellular processes such as gene expression, hormonal signaling, RNA processing, DNA replication, recombination and repair.
Faculty and Research Interests
Gene structure and regulation
Regulation of DNA replication, cell cycle, cancer
Molecular mechanisms of plant-pathogen interactions and plant gene expression
Gene regulation, Post-transcriptional control of messenger RNA stability, Translation and localization by RNA-binding proteins, mRNA untranslated regions and nucleases, Genetic mechanisms of development, Cancer, Obesity
Mechanisms of purposeful mutation relating to innate and adaptive immunity
Mechanisms of mammalian DNA double-strand break repair
Gene expression; protein phosphorylation cascades.
Genome stability, mutation; DNA replication, repair and genetic recombination.
Eukaryotic molecular biology; hormone action; gene expression.
Nucleic acid biochemistry; molecular genetics.
Cellular mechanisms of maintaining genomic stability; DNA damage response during chromosomal replication.
Howard C. Towle
Nutritional and hormonal regulation of mammalian gene expression.
Mechanism of insulin action; regulation of gene expression by lipids; lipid transporters and lipid binding proteins; obesity and metabolic regulation.
Biological networks that coordinate metabolism and growth
Signal Transduction, Natriuretic Peptides, Guanylyl Cyclase Receptors and cGMP.
Nucleic acid biochemistry; molecular biology.
Joint Members - From Other Departments
Regulation of gene expression; cancer
Determination of the animal body plan; patterning of the eye; biochemical properties of auto-processing systems
Cytoskeleton and cell motility; Developmental mechanisms
Role of protein tyrosine phosphatases in cell differentiation and cell adhesion
Cerebellar gene expression; mammalian development; histocompatability genes
Temporal control of development; gene expression; protein-DNA interactions
Molecular biology of animal development; gene expression; protein-protein and protein-DNA interactions
Sex determination; regulation of gene expression in development