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Chemical and Structural Biology Division

Faculty and research interests

Primary Members

Hideki Aihara

Molecular mechanisms of DNA rearrangement/recombination reactions

Ian M. Armitage

Multinuclear magnetic resonance techniques; metalloproteins/metal homeostasis; Alzheimer's Disease.

Wendy Gordon

Mechanotransduction; X-ray crystallography; Single molecule force spectroscopy; Regulated Intramembrane Proteolysis; Cell signaling assays; Protein labeling

Charalampos Babis Kalodimos

Biomolecular NMR spectroscopy; Protein dynamics; Molecular machineries; Cell signaling; Molecular chaperones; Membrane transporters

John D. Lipscomb

Oxygenase mechanisms, metalloproteins, magnetic resonance techniques, kinetics.

Kevin H. Mayo

Cell adhesion; protein-protein/carbohydrate interactions.

Douglas H. Ohlendorf

Protein engineering; structural biology; x-ray crystallography; molecular biology.

David D. Thomas

Muscle molecular dynamics, spectroscopy, and therapeutic discovery.

Gianluigi Veglia

(Division Head)

Structure and dynamics of membrane embedded enzymes. (Division Head)

Carrie M. Wilmot

Structural enzymology: Metal ions & organic co-factors; Human disease: cardiovascular, Alzheimers.

Secondary Members

Do-Hyung Kim

Biological networks that coordinate metabolism and growth.

Alex J. Lange

Diabetes, metabolite sensing and signaling, metabolic enzyme regulation.

Joint Members - From Other Departments

Que, Jr., Lawrence
(Chemistry)

Active site structures and mechanisms of nonheme iron enzymes; trapping of reactive intermediates, design and synthesis of functional metalloenzyme models and chiral oxidation catalysts; artificial DNA hydolysis agents.

Chemical and Structural Facilities

Facilities

Biophysical Technology Center
Director: Dr. Mike Autry
Optics Manager: Dr. Ji Li
EPR Manager: Dr. Andrew Thompson

Kahlert Structural Biology Laboratory
Director: Dr. Carrie Wilmot
Manager: Ed Hoeffner

Nano Crystallization Facility
Director: Dr. Douglas Ohlendorf
Manager: Ke Shi

Nuclear Magnetic Resonance Facility
Director: Dr. Gianluigi Veglia
Manager(s): Todd Rappe, Youlin Xia, Gopinath Tata

Faculty Research Interests

X-Ray Crystallography
Hideki Aihara
Douglas H. Ohlendorf
Carrie M. Wilmot

Nuclear Magnetic Resonance
Ian M. Armitage
Kevin H. Mayo
Hiroshi Matsuo
Gianluigi Veglia
Kylie Walters

Spectroscopy and other Biophysical Methods
John Lipscomb
David Thomas