Faculty by Division

Synthetic Biology and Biotechnology Division

 

Mikael Elias, Assistant Professor

(612) 626-1915 | mhelias@umn.edu

Biological macromolecules comprise fantastic objects with nearly unlimited activities and potentialities. Their use in biotechnology has already changed several segments of industry including the detergents, paper industries, the food industry (e.g. sugar), and is expected to revolutionize the medical industry.

Our Lab aims to decipher the mechanisms by which those molecules evolve, to understand the molecular basis of their biological functions, and to develop new methods for their engineering, with the aim of developing soft, ecological solutions to existing or emerging society issues.


Michael Freeman, Assistant Professor

(612) 624-8575 | mffreema@umn.edu

Our work focuses on the discovery and heterologous expression of pathways and genes involved in the biosynthesis of metabolites from unique microbial sources.


Romas J. Kazlauskas, Professor and Director of Graduate Studies BMBB Graduate Program

(612) 624-5904 | rjk@umn.edu

Biocatalysis uses enzymes for unnatural purposes - synthesis of drugs, chemical intermediates & biofuels. Using enzymes creates more efficient syntheses that minimize pollution and avoid toxic and non-selective chemical reagents.


Arkady B. Khodursky, Associate Professor

(612) 625-3799 | khodu001@umn.edu

Mechanisms of adaptation in antibiotic resistant bacteria; Genomic landscape of starvation-recovery transitions in bacterial populations


Claudia Schmidt-Dannert, Distinguished McKnight Professor

(612) 625-5782 | schmi232@umn.edu

Microbes and plants synthesize a tremendous diversity of chemical compounds that is unmatched by synthetic methods. We are interested in exploring and utilizing the metabolic machineries of plants and microorganisms to enable the discovery and synthesis of valuable compounds in recombinant microbial hosts. We combine enzyme functions obtained from different sources into new metabolic reactions sequences for desired compounds.


Janet Schottel, Professor

(612) 624-6275 | schot002@umn.edu

One of my primary research interests focuses on the regulation of gene expression in cells in response to stresses such as desiccation, nutrient deprivation, culture density, osmotic stress, heat shock, and mechanical stress. Our approaches include studying the regulation of transcription, mRNA degradation and protein synthesis in cells grown under a variety of culture conditions.


Burckhard Seelig, Associate Professor

(612) 626-6281| seelig@umn.edu

Our research focuses on implementing Darwinian evolution in a test tube to generate novel proteins with custom-made properties.  We are interested in applying methods of in vitro selection and evolution to the generation of de novo enzymes as well as to tailoring existing enzymes to a wide variety of useful properties.


Michael Smanski, Assistant Professor

(612) 624-9752 | smanski@umn.edu

Current research topics: Natural products discovery in the post-genomics era; Precision engineering of diverse bacterial species


Lawrence P. Wackett, Distinguished McKnight University Professor

(612) 625-3785 | wacke003@umn.edu

The Wackett laboratory investigates enzyme transformations for biotechnological applications. The applications focus on biodegradation for environmental purposes and biocatalysis for producing specialty chemicals or detection kits.


Carrie M. Wilmot, Associate Head

(612) 624-2406 | wilmo004@umn.edu

My primary interest is to understand the mechanisms of post-translational modification required for protein enzyme activity. Post-translational modifications of proteins, such as phosphorylation and glycosylation, are well known modulators of signaling pathways and molecular/cellular recognition.


Molecular Biology Division

 

Kenneth W. Adolph, Associate Professor

(612) 625-8467 | adolp001@umn.edu

Research in my laboratory is concerned with the genes for the thrombospondin (TSP) proteins and the metaxin (MTX) proteins. Another research focus has been to sequence cDNAs for a new metaxin protein (MTX3), not previously described, in zebrafish and Xenopus.


Anja-Katrin Bielinsky, Professor

(612) 624-2469 | bieli003@umn.edu

DNA replication is an integral part of the eukaryotic cell cycle, which coordinates the duplication of the entire genome during S phase. At the onset of S phase, origins of DNA replication are activated to "fire". Once DNA synthesis has been initiated, the cell is committed to undergo a complete round of division.

 


Anath Das, Professor

(612) 624-3239 | dasxx002@umn.edu

Molecular mechanisms of plant-pathogen interactions and plant gene expression

 


Zigang Dong M.D., Dr.P.H., Professor

(507) 437-5600 | dongx004@umn.edu

The major focus in the Cellular and Molecular Biology section is the molecular mechanisms of cancer development and the actions of chemopreventive agents in cancer prevention.

 


Aaron Goldstrohm, Associate Professor

(612) 626-7497 | agoldstr@umn.edu

Our goal is to discover the principles and mechanisms that control expression of genes, with the benefit to society that this knowledge will enhance our understanding of the causes of disease and advance therapeutic strategies to correct deleterious gene expression.


Reuben S. Harris, Professor

(612) 624-0457 | rsh@umn.edu

The Harris lab is interested in mechanisms of mutation in immunity and carcinogenesis. Please see our website for information and links.

 


Eric A. Hendrickson, Professor

(612) 624-5988 | hendr062@umn.edu

Our objective is to gain an understanding of the molecular and biochemical mechanisms of mammalian DNA double-strand break (DSB) repair.  The importance of DNA DSB repair is underscored by the existence of human cancer predisposition diseases, such as Nijmegen chromosome breakage syndrome, ataxia telangiectasia and Fanconi's anemia, which are caused by defects in DNA repair.


David C. LaPorte, Professor

(612) 625-4983 | DLaPorte@umn.edu

Every biological process is regulated by several different control mechanisms. Our research focuses on how the individual mechanisms work and how they are coordinated with each other. We are studying the regulation of the glyoxylate bypass in the bacterium Escherichia coli. We chose this organism because it can be manipulated with a variety of powerful genetic techniques.


Michel M. Sanders, Distinguished University Teaching Professor

(612) 624-9637 | sande001@umn.edu

Most eucaryotic genes are controlled by developmental, hormonal, tissue-specific, and/or nutritional cues. Insight into these complex regulatory events is fundamental to our understanding of the processes controlling cellular proliferation and oncogenesis, differentiation, and development. The long-term goal of the research in my laboratory focuses on investigating how estrogen and testosterone regulate gene expression, both physiologically and pathologically. To address this, we are investigating the structure and function of the estrogen- and testosterone-responsive ZEB-1 (delta EF1) transcription factor.


Paul G. Siliciano, Associate Professor, Associate Head, and Director of Undergraduate Studies - Biochemistry

(612) 625-4928 | pauls@umn.edu

Virtually all genes in higher organisms are interrupted by regions of noncoding DNA called introns. These introns must be removed from messenger RNA precursors to allow proper gene expression. The process of pre-mRNA splicing is responsible for accurately identifying introns and catalyzing their excision. A fundamental challenge in modern molecular biology is to understand how the splicing apparatus specifically recognizes and removes introns. Because the splicing machinery is highly conserved throughout evolution, my laboratory approaches this question using the genetic and biochemical tools available uniquely in the yeast Saccharomyces cerevisiae.


Alexandra Sobeck, Associate Professor

(612) 624-1343 | asobeck@umn.edu

The stability of the cellular genome is constantly threatened by a variety of exogenous and endogenous mutagenic agents such as UV light, reactive oxygen species, etc. Cells protect their genome against carcinogenic alterations by using a complex network of “caretaker” proteins that function to maintain the integrity of the cellular chromosomes. Inherited defects in these caretaker genes are the cause of genomic instability syndromes in humans, such as Fanconi Anemia or Bloom syndrome, characterized by a highly elevated risk to develop certain types of cancer. We study these diseases to understand and discover novel mechanisms important to control and suppress cancer susceptibility.


Metabolic & Systems Biology Division

David A. Bernlohr, Distinguished McKnight Professor and Head, Cargill Chair in Systems Biology of Human Metabolism

(612) 624-2712 | bernl001@umn.edu

A major research study in the laboratory focuses on the metabolic relationships between obesity and insulin action. Our laboratory specifically examines cytoplasmic fatty acid binding proteins and their role(s) in mediating fatty acid metabolism in adipocytes and macrophages, particularly leukotriene synthesis.


Yue Chen, Assistant Professor

(612) 626-3340 | yuechen@umn.edu

We have developed highly efficient mass-spectrometry based technology for system-wide identification and quantification of PTM sites and established the bioinformatics platform for understanding the functional relevance of the PTMs in protein structure and cellular physiology.


James M. Ervasti, Professor

(612) 626-6517 | jervasti@umn.edu

Our objective is to fully define the function of dystrophin in striated muscle to understand how its absence or abnormality leads to the pathologies observed in Duchenne and Becker muscular dystrophies.  Our unique approach integrates biochemical and biophysical analyses of the very large dystrophin protein with in vivo assessments of its function in transgenic mouse models of muscular dystrophy.


Timothy J Griffin, Associate Professor; Director, Center for Mass Spectrometry and Proteomics

(612) 624-5249 | tgriffin@umn.edu

Work in our group involves the development and application of mass spectrometry-based tools to study proteins and proteomes. The goal of this work is to provide the necessary tools to enable the system-wide characterization of proteins expressed within a cell, tissue, biological fluid or organism, in order to better understand basic mechanisms of biological function and disease.


Do-Hyung Kim, Associate Professor

(612) 626-3418 | dhkim@umn.edu

We are interested in understanding the molecular networks that coordinate nutrient metabolism and cell growth.  How cells assess nutrient- or energy states and relay this information into appropriate decisions on growth is poorly understood. Coordinate regulation of nutrient metabolism and cell growth is of fundamental importance, and many human diseases, such as cancer, diabetes, and developmental disorders, are affected by alterations in this process.


Alex J. Lange, Associate Professor

(612) 626-4502 | lange024@umn.edu

The liver plays a central role in the maintenance of normal blood glucose levels (euglycemia), which is essential for good health. Dysregulation of blood glucose levels leads either to hypoglycemia or diabetes. In that regard, we study the small molecule, fructose-2,6-bisphosphate, which is a key regulator of liver metabolism with respect to maintaining euglycemia.


Douglas Mashek, Associate Professor

(612) 626-2904 | dmashek@umn.edu

Our laboratory is interested in characterizing the alterations in metabolism that define diseases such as fatty liver disease and Type 2 Diabetes.  A a major emphasis is on lipid droplet biology and how lipid droplet proteins regulate metabolism and cell signaling.  For more information, see our lab website.


Sharon E. Murphy, Professor

(612) 624-7633 | murph062@umn.edu

We study the metabolism of nicotine and nitrosamines. Nicotine is not a carcinogen, but nitrosamines are potent carcinogens and are believed to be causative agents for a number of human cancers.  We are particularly interested in the tobacco specific nitrosamine, NNK.  NNK requires cytochrome P450-catalyzed metabolism to exert its carcinogenic potential.


Laurie Parker, Associate Professor

(612) 624-9066 | llparker@umn.edu

Our research program is broadly directed at assay development for post-translational modifications (PTMs), with a focus on protein phosphorylation by tyrosine kinases. Protein tyrosine kinases play key roles in disease and are particularly important in cancer: mutations in several protein tyrosine kinase genes have been identified as drivers of many tumor types and drugs targeted at inhibiting these enzymes represent ~20% (>$9 billion) of the current oncology market.


Lincoln Potter, Professor

(612) 624-7251 | potter@umn.edu

Our research focuses on the hormone/parascrine natriuretic peptide family and their cognate guanylyl cyclase (GC)-A and GC-B receptors. These signaling pathways regulate blood pressure, bone growth, reproduction, metabolism and other functions. Over the past few years, we have worked on the four natriuiretic peptide related research areas described below.


Robert J. Roon, Associate Professor

(612) 625-9479 | roonx001@umn.edu

Amino acid transport and amino acid neurotransmission in the mammalian brain.


Jeongsik Yong, Assistant Professor

(612) 626-2420 | jyong@umn.edu

Current research topics:

Chemical & Structural Biology Division

 

Hideki Aihara, Associate Professor

(612) 624-1491 | aihar001@umn.edu

We are studying various DNA rearrangement systems relevant to human health including resolution of a concatenated DNA-replication intermediate into linear chromosomes in Borrelia burgdorferi, the Lyme disease spirochete and retroviral integration reaction in which the integrase protein encoded by HIV-1 and related retroviruses inserts viral DNA into the host's genome.


Ian M. Armitage, Professor

(612) 624-5977 | armit001@umn.edu

My laboratory is involved with the development and application of state-of-the-art multinuclear, multidimensional magnetic resonance methods to elucidate the structure, dynamics and mechanism of action of biological macromolecules.


Wendy Gordon, Assistant Professor

(612) 301-1196 | wgordon@umn.edu

Our lab is interested in how cell surface receptors convert signals from extracellular stimuli like mechanical force into a biological response, as dysregulation in a cell’s force-sensing ability can lead to disease.  We use X-ray crystallography and other biophysical methods to ask what “mechanosensors” look like in order to understand the range of structures nature uses to sense forces of different magnitudes and in different contexts, and hopefully identify potentially novel therapeutic targets.


Charalampos Kalodimos, Professor

(612) 626-7641 | ckalodim@umn.edu

Our lab works on two main objectives: first, the determination of the structural and dynamic basis for the function and assembly of large protein machineries; and second, the determination of the role of the internal protein dynamics in regulating protein activity and allosteric interactions. Our goal to tackle large and complex systems is arguably a very challenging one.


John D. Lipscomb, Professor

(612) 625-6454 | lipsc001@umn.edu

We investigate the mechanisms of oxygenases, the enzymes nature uses to catalyze the incorporation of oxygen into biological molecules. Oxygen incorporation reactions are important for a wide variety of reasons, ranging from activation of steroid hormones in humans to the detoxification of compounds in the environment. The oxygenases we study contain a metal which is the key to the chemistry they catalyze.


Hiroshi Matsuo, Associate Professor

(612) 626-6524 | matsu029@umn.edu

In my laboratory, nuclear magnetic resonance (NMR) spectroscopy is used to elucidate structures and mechanisms of biological macromolecules.

Current Projects: Structural Studies of Human APOBEC3G and HIV Vif; RNA in Viral DNA packaging; Mechanisms of Atypical Drug Kinetics and Interactions; Structural studies of human DEK protein


Kevin H. Mayo, Professor

(612) 625-9968 | mayox001@umn.edu

My research in structural biology is aimed at understanding cell adhesion at the molecular level where protein-protein and protein-carbohydrate interactions ae critical. Biomolecular conformations and interactions are analyzed primarily by using high resolution NMR spectroscopy, circular dichrosim spectropolarimetry and computer modeling.

 


Douglas H. Ohlendorf, Professor

(612) 624-8436 | ohlen001@umn.edu

My lab is interested in the structural foundations for biological function. Just as a picture is worth a thousand words, we believe a structure is worth a thousand pictures. Hypotheses suggested by the structures are tested through mutagenesis followed by biophysical characterization of mutants.


David D. Thomas, Professor

(612) 625-0957 | ddt@umn.edu

Our goal is to understand the fundamental molecular motions and interactions that are responsible for cellular movement, to determine the molecular bases of muscle disorders, and to devise novel therapies based on these discoveries. We approach this multidisciplinary problem with a wide range of techniques -- physiology, enzyme kinetics, molecular genetics, peptide synthesis, computer simulation -- but our forte is site-directed spectroscopic probes.


Gianluigi Veglia, Professor

(612) 625-0758 | vegli001@umn.edu

The overall goal of my group is to study the structure and dynamics of membrane embedded enzymes. We use a multidisciplinary approach, which includes molecular biology, multidimensional solution and solid-state NMR spectroscopy, and molecular modeling.