Nelson D. Goldberg Lectureship Series

 Sanford Burnham Medical Research Institute
 Diabetes and Obesity Research Center
 Orlando, FL
 Wednesday, March 6, 2013
 4:00-5:00 pm
 2-137 Jackson Hall
 Minneapolis Campus
  "Converging cyclic nucleotide second messengers regulate fat metabolism"


Nelson D. Goldberg received his B.Sci. in 1953 from the University of Toledo and following military service at Walter Reed Army Institute of Research, a Ph.D. in 1962 from the University of Wisconsin. He conducted postdoctoral studies with Oliver Lowry at Washington University School of Medicine and moved to the University of Minnesota in 1964 as an Instructor in Pharmacology. He moved quickly through the academic ranks, becoming Professor of Pharmacology in 1972 and Professor of Biochemistry in 1987. His energy and enthusiasm for science were evidenced through his diverse research interests in the area of signal transduction and metabolic control.

During his 40+ year career, he studied TCA-cycle intermediates in the brain, effects of insulin on cyclic nucleotide metabolism in the muscle, and hormonal control of glycogen turnover in the liver. Perhaps his most noteworthy studies were on the synthesis and metabolism of cGMP and its relationship to cAMP mediated signaling events. He demonstrated regulated synthesis of cGMP in response to cholinergic stimulation and developed analytical methods to measure not only the synthesis of phosphorylated molecules, but also their degradation. His interest in "high-energy" phosphoryl compounds continued into the 1990's as he studied the role of adenylate kinase in phosphoryl transfer reactions.


Dr. Jackie Corbin
Vanderbilt University Medical Center, Nashville, TN

Exploring Cyclic Nucleotide Action: Cyclic GMP, Penile Erection, & Viagra



Dr. Pere Puigserver
Harvard Medical School, Boston, MA

Signaling Control of Mitochondrial Bioenergetics Through the PGC1 Pathway.


Dr. Joesph Beavo
University of Washington, Seattle, WA

New roles for new and old phosphodiesterases.


Dr. Peter Roach
Indiana University School of Medicine, Indianapolis, IN

Glycogen, and Old New Trick? From Multisite Protein in Phosphorylation to Glycogen Phosphorylation to Lafora Disease.


Dr. Christin Carter-Su
University of Michigan Medical School, Ann Arbor, MI

The Role of the Tryosine Kinase JAK2 in Actions of Growth Hormone.


Dr. George Thomas
University of Cincinnati, Cincinnati

Nutrient Sensing in the mTOR/S6K1 Signaling Pathway.


Dr. Christopher B. Newgard
Duke University, Durham

Comprehensive Metabolic Analysis to Identify Mechanisms of Diabetes and Obesity.


Dr. Barbara B. Kahn
Harvard Medical School, Boston

AMP-Activated Protein Kinase: Ancient fuel Gauge is a Key to Modern Understanding of Metabolism.


Dr. Morris J. Birnbaum
University of Pennsylvania

The Coordinated Control of Growth and Metabolism.


Dr. M. Daniel Lane
Johns Hopkins School of Medicine

The Malonyl-CoA Hypothesis and Regulation of Energy Metabolism.


Dr. G. Stanley McKnight
University of Washington, Seattle

Physiological Functions of Protein Kinase A.


Dr. Tony Hunter
The Salk Institute, La Jolla

Cellular Regulation by Phosphorylation and Ubiquitination.


Dr. David Garbers
UT Southwestern Medical Center, Dallas