When Dr. Xiaokang Lun, a new assistant professor in the Department of Genetics and Cell Biology, speaks about his work at the University of Minnesota, his enthusiasm is palpable. "Each cell has its own narrative, and by deciphering these stories, we can tailor therapies that are uniquely effective for individual patients," he explains.
Dr. Lun’s lab, initiated in January, specializes in the field of single-cell system biology. This area of research focuses on understanding the complex behaviors and functions of individual cells, rather than groups of cells. His lab utilizes a technique known as mass cytometry to analyze and quantify proteins and their activities in each cell, helping to reveal how cells respond to various treatments or diseases. Additionally, Dr. Lun’s team develops innovative DNA-based technologies to create molecular probes designed to detect specific cellular activities or changes. These probes are crucial for diagnosing diseases more accurately and developing personalized therapies.
Originally from Beijing, Dr. Lun's academic journey led him to Switzerland for his Ph.D., where he became interested in the complexities of cellular behavior. "The intricate dance of cells responding to environmental cues was mesmerizing to me," he recalls. His path in science next took him to Boston, where he spent five years at the Wyss Institute at Harvard University. It was there that his focus on technology development deepened, particularly around DNA and nucleic acid-based methodologies for crafting reactive probes.
Now settled in Minnesota with his family, Dr. Lun is invigorated by the supportive academic environment at the U of M. "The collegial atmosphere here is incredibly conducive to innovation and academic growth. The support from colleagues and the community alike is instrumental in helping new faculty like myself establish and expand our research programs," he acknowledges. This supportive backdrop was a pivotal factor in his decision to join the U of M.
Though he's lived in many places, Minnesota already feels like home to Dr. Lun, especially given his and his wife’s fondness for the cold. "It's pretty good, actually, for us. We both like winter sports," he laughs. This enjoyment of winter recreation has helped Dr. Lun and his family feel connected to their new surroundings, finding joy and community through activities.
In his lab, Dr. Lun and his team are dedicated to developing diagnostic tools that could revolutionize treatment for cancer patients who do not respond to standard therapies. "Our mission is to unravel what cells in the human body are actively doing in real-time, which can be pivotal in understanding and combating disease processes," he states. This endeavor not only highlights his scientific ambition but also underscores a broader commitment to enhancing precision medicine, a field that promises more personalized and effective interventions based on individual cellular behaviors.
Looking forward, Dr. Lun is optimistic about the future of his laboratory. "In the next five years, I envision our lab as a leader in single cell proteomics, especially in translating our findings into clinical applications that can offer real solutions to patients," he says. His goal is to see his team's research contribute to the understanding of disease at the cellular level and to the development of treatments that are finely adjusted to the needs of individual patients. – Elena Montanye