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Discovery Proteomics

Doug MashekQuantitative analysis of the murine lipid droplet-associated proteome

Salmaan Ahmed Khan et al. J. Lipid Res. 2015;56:2260-2272

  • Accumulation of lipid droplets is the defining feature of non-alcoholic fatty liver disease (NAFLD).
  • Using iTRAQ labeling, the authors for the first time compared the proteome of hepatic lipid droplets of mice with or without NAFLD.
  • The analysis identified proteins that were increased or decreased in abundance in lipids droplets in this disease model, thereby, providing Salmaan Khannew insights and potential therapeutic targets towards NAFLD.

analysis of the murine lipid droplet-associated proteome