Dr. Oetting's research focuses on the genetic analysis of common diseases. His major research is identifying genetic variants associated with adverse outcomes in solid organ transplantation. This work is includes using a high density SNP chip for association studies. My research in transplantation also includes proteomic analysis of urine to identify biomarkers associated with different clinical outcomes.
Dr. Oetting is also interested in determining variants associated with susceptibility to asthma. The lab has identified several loci associated with asthma in families and we are currently mapping theses asthma susceptibility genes.
Selected Publications (Pubmed Search)
Akkina S, Zhang Y, Nelsestuen G, Oetting WS, Ibrahim HN. 2009. Temporal stability of the urinary proteome after kidney transplant: more sensitive than protein composition? Journal of Proteome Research 8:94-103.
Oetting WS, Pietsch, J, Brott, MJ, Savage S, Fryer JP, Summers CG, King, RA. 2009. The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism. American Journal of Medical Genetics 149A:466-469.
Zhang Y, Oetting WS, Harvey SB, Stone MD, Monkkonen T, Matas AJ, Nelsestuen GL. 2009 Urinary protein profiles: diagnosis and prognosis of kidney transplant outcomes. Transplantation 87:1807-1813.
He H, Oetting WS, Brott MJ and Basu S. 2009. Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene interaction in a case-control study. BMC Medical Genetics 10:127.
He H, Oetting WS, Brott MJ and Basu S. 2010. Pair-wise multifactor dimensionality reduction method to detect gene-gene interactions in a case control study. Human Heredity69:60-70.
Israni A, Leduc R, Holmes J, Jacobson PA, Guan W, Schladt D, Chen J, Matas AJ, Oetting WS. 2010. Single nucleotide polymorphisms, acute rejection and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. Transplantation90:1401-1408.
Jacobson PA, Schladt D, Oetting WS, Leduc R, Guan W, Matas AJ, Lamba V, Mannon RB, Julian BA, Israni A for the DeKAF investigators. 2011. Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation. Transplantation 91:309-316.
Jacobson PA, Oetting WS, Brearley AM, Leduc R, Guan W, Schladt D, Matas AJ, Lamba V, Julian BA, Mannon RB, Israni A for DeKAF investigators. 2011. Novel polymorphisms associated with tacrolimus trough concentrations: Results from a multicenter kidney transplant consortium. Transplantation 91:300-308