Wu, C., Okar, D.A., Kang, J., Lange, A.J. (2004) Reduction of Hepatic Glucose Production as a Therapeutic Target in the Treatment of Diabetes. Curr. Drug Targets, In Press.

Okar, D. A., Wu, C., Lange, A. J. (2004) Regulation of the Regulatory Enzyme, 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase. Advances in Enzyme Regulation, (G. Weber, Ed.) 44, In press.

Baltrusch, S., Wu, C, Okar, D.A., Tiedge, M. and Lange, A.J. (2004) Interaction of GK with the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PF2K/F26P2ase) Frontiers in Diabetes, Karger Press, (F. Matschinsky and M. Magnuson, eds.), In press.

Massa, L., Baltrusch, S, Okar, D., Lange, A.J., Lenzen, S. and Tiedge, M. (2004) Interaction of PFK-2/FBPase-2 with Glucokinase activates Glucose Phosphorylation and Glucose Metabolism in Insulin-producing Cells. Diabetes, In press.

Wu, C., Okar, D.A., Stoeckman, A.K., Peng, L-J., Herrera, A.H., Herrera, J.E., and Lange, A.J. (2004). Fructose-2, 6-bisphosphate Regulates Hepatic Gene Expression of Glucokinase and Glucose-6-phosphatase in the Absence of Insulin. Endocrinology 145(2):650-658.

Zangger, K., Pervushin, K., Sterk, H., Lange, A.J., Okar, D.A. (2003) Sequence-specific 1H, 13Cand 15N Resonance Assignments of the Rat Liver Fructose-2,6-bisphosphatase domain. J. Biomolecular NMR, 27: 281-282.

Choi, I-Y., Wu, C., Okar, D.A., Lange, A.J., and Gruetter, R. (2002). Elucidation of the Role of Fructose-2,6-bisphosphate in the Regulation of Glucose Fluxes in Mice using In Vivo 13C-NMR Measurements of Hepatic Carbohydrate Metabolism. Eur. J. Biochem., 269: 4418-4426.

Tanaka, N., Dumay, V., Liao, Q., Lange, A.J., Wever, R. (2002). Bromoperoxidase activity of vanadate-substituted acid phosphatases from Shigella flexneri and Salomella entrica ser. typhinurium. Eur. J. Biochem. 269: 2162-2167.

McFalls, E.O., Murad, B., Liow, J.-S., Gannon, M.C., Haspel, H.C., Lange, A.J., Marx, D., Sikora, J., and Ward, H.B. (2002) Glucose Uptake and Glycogen Levels are Increased in Pig Heart after Repetitive Ischemia. Am. J. Physiol. Heart Circ. Physiol. 282: H205-H211.

Wu, C., Okar, D.A., Newgard, C.B., and Lange, A.J. (2002). Increasing Fructose-2,6-bisphosphate Overcomes Hepatic Insulin Resistance of Type 2 Diabetes, Am. J. Physiol Endocrinol Metab, 282: E38-E45.

Baltrusch, S., Lenzen, S., Okar, D.A., Lange, A.J., and Tiedge, M. (2001). Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library - identification of PFK-2/FBPase-2 as a novel interaction partner. J. Biol. Chem. 276: 43915-43923.

Okar, D.A., Manzano, A., Navarro-Sabate, A. Riera, L., Bartrons, R., and Lange, A. J. (2001). PFK-2/FBPase-2: Maker and Breaker of the Essential Biofactor Fructose-2,6-Bisphosphate. Trends in Biological Sciences, 26:30-35.

Wu, C., Okar, D.A., Newgard, C. B., and Lange, A. J. (2001). Overexpression of 6-Phosphofructo-2, 6-bisphosphatase in Mouse Liver lowers Blood Glucose by Suppression of Hepatic Glucose Production. J. Clin. Invest. 107: 1-8.

Okar, D.A., Live, D.H., Devany, M.H., and Lange, A.J. (2000). The mechanism of the Bisphosphatase Reaction of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase Probed by 1H-15N Spectroscopy. Biochemistry. 39: 9754-9762.

van der Werve, G., Lange, A.J., Newgard, C.B., Mechin, M.-C., Li, Y. and Berteloot, A. (2000). New Lessons in the Regulation of Glucose Metabolism taught by the Glucose-6-phosphatase System. Invited review, Eur. J. Biochem. 267: 1533-1549.

Aiston, S., Trinh, K., Lange, A. J., Newgard, C. B., Agius, L. (1999). Glucose-6-phosphatase Overexpression Lowers Glucose 6-Phosphate and Inhibits Glycogen Synthesis and Glycolysis in Hepatocytes without Affecting Glucokinase Translocation. EVIDENCE AGAINST FEEDBACK INHIBITION OF GLUCOKINASE. J. Biol. Chem. 274: 24559-24566.

Manzano, A., Xavier Perez, J., Nada, M., Estivill, X., Lange, A.J., and Bartrons, R. (1999). Cloning, Expression and chromosomal localization of human testis of 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase Gene. Gene, 229:83-87.

Okar, D.A, and Lange, A.J. (1999). Fructose-2,6-bisphosphatase and Control of Carbohydrate Metabolism in Eukaryotes. Biofactors, 10:1-14.

Nordlie, R. C., Foster, J., and Lange, A.J. (1999). Regulation of Glucose Production by the Liver. Ann. Rev. of Nutr., 19:379-406.

Miller, S., Karschnia, E., Anand, G., Bell, G.I., Laporte, D., and Lange, A.J. (1999). Characterization of Glucokinase Mutations Associated with Maturity Onset Diabetes in the Young Type 2 (MODY-2): Different Glucokinase Defects Lead to a Common Phenotype. Diabetes, 48:1645-1651.

Okar, D.A., Live, D.H., Kirby, T.L., Karschnia, E.J., von Weymarn, L., Armitage, I.M. and Lange, A.J. (1999) The Roles of Glu-327 and His-446 in the Bisphosphatase Reaction of Rat Liver 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase Probed by NMR Spectroscopic and Mutational Analyses of the Enzyme in the Transient Phosphohistidine Intermediate Complex. Biochemistry, 38:4471-4479.

Trinh, K.Y., O'Doherty, R.M., Anderson, P., Lange, A.J., Newgard, C.B. (1998) Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. J. Biol. Chem. 273(47):31615-20.

Heine-Suner, D., Diaz-Guillen, M.A., Lange, A.J., Rodriguez de Cordoba, S. (1998) Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2). Eur. J. Biochem. 254(1):103-110.

Okar, D. A., Lee, Y. -H, Argaud, D., McFarlan, S.C., and Lange, A.J. (1998). The 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase system: Regulation by Insulin and an Insulinomimetic Approach to Lowering Blood Glucose Levels. Frontiers in Diabetes Belfiore F; Lorenzi, M., Molinatti, G.M., and Porta, M. (eds) S. Karger AG, Basel, Vol. 14, pp 30-46.

Okar, D.A., Felicia, N.D., Gui, L., Lange, A.J. (1997) Labeling of recombinant protein for NMR spectroscopy: global and specific labeling of the rat liver fructose 2,6-bisphosphatase domain. Protein. Expr. Purif. 11(1):79-85.

Argaud, D., Kirby, T., Newgard, C.B., and Lange, A.J. (1997). Glucose and Fructose-2,6-bisphosphate Stimulation of Glucose-6-phosphatase Gene Expression in Fao Rat Hepatoma Cells. J. Biol. Chem. 272: 12854-12861.

McFarlan, S.C., Zhang, Q., Miksicek, R.J., and Lange, A.J. (1997). Characterization of an Intronic Hormone Response Element of the Rat Liver/Skeletal Muscle 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase Gene. Mol Cell. Endocrinol. 129: 219-227.

Lee, Y.-H., Olson, T.W., Ogata, C., Levitt, D.G., Banaszak. L., and Lange, A.J. (1997). Crystal Structure of an Active Phospho-enzyme Intermediate of Rat Liver Fructose-2,6-bisphosphatase: Implications for Kinetic Mechanism. Nature Structural Biology 4: 615-619.

Trinh, K., Minassian, C., Lange, A.J., and Newgard, C.B. (1997). Expression of the Catalytic Subunit of Glucose-6-phosphatase in INS-1 Cells: Effects on Glucose Cycling, Glucose Usage, and Insulin Secretion. J. Biol. Chem. 272:24837-24842.

Seone, J., Trinh, K., O’Doherty, R.M., Gome-Foix, A.M., Lange, A.J., Newgard, C.B., and Guinovart, J.J. (1997). Metabolic Impact of Adenovirus-Mediated Overexpression of the Glucose-6-Phosphatase Catalytic Subunit in Hepatocytes. J. Biol. Chem. 272: 24837-24842.

Argaud, D., Zhang, Q., Maitra, S.R., Pan, W., Pilkis, S.J., and Lange, A.J. (1996). Isolation and Characterization of Rat Liver Glucose-6-phosphatase Gene: Regulation of Gene Expression in Different Endocrine and Nutritional States. Diabetes 45: 1563-1571.

Jaoquin, M., Salvado, C., Bellosilo, B., Gil, J., Lange, A.J., and Tauler, A. (1996). Effect of Growth Factors on the Expression of 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase in Rat-1 Fibroblasts. J. Biol. Chem. 272: 2846-2851.

Okar, DA, Kakalis, LT, Narula, SS, Armitage, IM, Pilkis, SJ, (1995), Biochemical Journal, 308, 189-195. Identification of transient intermediates in the bisphosphatase reaction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by ³¹P-NMR spectroscopy.

Li, L., Yao, W., Lange, A.J., Pilkis, S.J., Dong, M., Yin, Y., and Xu, G. (1995). Expression of Chicken Liver 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and its Bisphosphatase Domain in Escherichia coli. Biochem. Biophys. Res. Comm. 209: 883-893.

Pilkis, S.J., Claus, T., Kurland, I.J., and Lange, A.J. (1995). 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase: A Metabolic Signaling Enzyme. Ann. Rev. Biochem. 64: 799-835.

Scott, P., Lange, A.J., Pilkis, S.J., and Kruger, N.J. (1995). Carbon Metabolism in Leaves of Transgenic Tobacco (Nicotiana tabacum) Containing Elevated Fructose 2,6-Bisphosphate Levels. Plant J. 7 : 461-469.

Argaud, D., Lange, A.J., Becker, T.C., Okar, D.A., El-Maghrabi, M.R., Newgard, C.B., and Pilkis, S.J. (1995). Adenovirus-mediated Overexpression of Liver 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase in Gluconeogenic Rat Hepatoma Cells: Paradoxical Effect on Fru-2,6-P2 Levels, J. Biol. Chem. 270 (41): 24229-24236.

Ventura, F., Ambrosio, S., Bartrons, R., El-Maghrabi, M.R., Lange, A.J., and Pilkis, S.J. (1995). Isolation of a cDNA for Bovine Brain 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Biochem. Biophys. Res. Comm. 209: 1140-1148.

El-Maghrabi, M.R., Lange, A.J., Jiang, W., Yamagata, K., Stoffel, M., Takeda, J., Fernald, A.A., Le Beau, M.M., Bell, G.I., Baker, L., and Pilkis, S.J. (1995). Human Fructose-1-bisphosphatase Gene (FBP1): Exon-Intron Organization, Localization to Chromosome Bands 9q22.2-q22.3, and Mutation Screening in Subjects with Fructose-1-bisphosphatase Deficiency. Genomics 27: 520-525.

Lange, A.J., Argaud, D., El-Maghrabi, M.R., Pan, W., Maitra, S.R., and Pilkis, S.J. (1994). Isolation of a cDNA for the Catalytic Subunit of Rat Liver Glucose-6-Phosphatase: Regulation of Gene Expression by Insulin, Dexamethasone and cAMP. Biochem. Biophy. Res. Comm. 201: 302-309.

Maitra, S.R., Pan, W., Lange, A.J., El-Maghrabi, M.R., Abumrad, N.N., and Pilkis, S.J. (1994). Glucose-6-phosphatase Gene Expression and Activity are Modulated in Hemorrhagic Shock: Evidence for a New Heat-Sensitive Activator. Biochem. Biophy. Res. Comm. 204: 716-724.

Updated 8/2/00 by Mary Petrie-Terry