APOBEC3G (apolipoprotein B messenger-RNA-editing enzyme, catalytic polypeptide-like 3G) is a single-strand DNA deaminase that inhibits the replication of HIV-1 and other retroviruses. Both APOBEC3G and APOBEC3F specifically target HIV-1 through cytidine de-aminase activities. Viral infectivity factor (Vif), from HIV, protein circumvents these actions through degradation. The structure of these proteins, and other related proteins, will help promote understanding of their functions and allow for targeted design of new therapies in HIV infection.
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