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HIV-1 Capsid


The capsid of HIV-1 plays an essential role in its viral life cycle, and is thus a prime target for drug therapy. CA, HIV-1’s capsid protein, is a large portion of the viral precursor proteins which interact with the various host and viral replicative machinery. Understanding the biophysical mechanisms of these interactions will allow for generation of new antiviral therapy drugs.


Brandie J Kovaleski, Robert Kennedy, Ahmad Khorchid , Lawrence Kleiman, Hiroshi Matsuo, and Karin Musier-Forsyth. "Critical role of helix 4 of HIV-1 capsid C-terminal domain in interactions with human lysyl-tRNA synthetase." Journal of biological chemistry 282.44 (2007):32274-32279.

Varun Dewan, Tao Liu, Kuan-Ming Chen, Ziqing Qian, Yong Xiao, Lawrence Kleiman, Kiran V. Mahasenan, Chenglong Li, Hiroshi Matsuo, Dehua Pei, and Karin Musier-Forsyth. "Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction." ACS chemical biology (2012)