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Center for Mass Spectrometry and Proteomics
The Center for Mass Spectrometry and Proteomics facility provides support, equipment, and expertise for analyzing complex protein mixtures. Mass spectrometric data can provide intact protein molecular weight as well as protein identification by peptide mass fingerprint or MS/MS data, combined with protein database searching. In addition, some mass spectrometers provide accurate mass measurement for organic molecules and relative protein quantification via isotope labeling techniques (e.g., iTRAQ™).
The center also has equipment to help with complex protein separation and differential expression of protein between two samples. The facility has the capability of traditional 2D SDS-PAGE, DIGE, PF (2D liquid chromatofocusing) and high throughput spot picking, digestion, and desalting.
In addition, the Center offers Proteomics Workshop several times a year. |
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Sponsored by the offices of the Senior Vice President for Health Science and the Vice President for Research, the University of Minnesota announces the Mass Spectrometry and Proteomics (MSP) Initiative. The MSP initiative is a 4-year, $2M program beginning in FY05 that provides expanded opportunities for basic, translational and clinical research in the uses of mass spectrometry and proteomics for biomedical research. Through a combination of seed grants (via the BioMedical Genomics Center), training workshops, seminars, bioinformatic and technical staff support, investigators will be able to initiate, develop and expand projects utilizing proteomic technology. Such infrastructure investments allow investigators access and training in technologies critical for successful RO1, PO1, SCORE and Center grant applications. For information, contact David Bernlohr (bernl001@umn.edu) or Vivek Kapur (vkapur@umn.edu). |
UM/Mayo Partnership
The Center for Mass Spectrometry and Proteomics
Infrastructure Grant
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The Minnesota Partnership for Biotechnology and Medical Genomics is a unique collaborative venture among the Mayo Clinic, University of Minnesota, and State of Minnesota. The Partnership seeks to position Minnesota as a world leader in biotechnology and medical genomics applications that will result in important new medical discoveries, thereby improving health care for patients and supporting the development of new business and jobs in Minnesota. As a part of this program, five grants for infrastructure development were awarded in 2006. One of these grants was for a collaborative effort between the Proteomics Facility at the Mayo Clinic and the Center for Mass Spectrometry and Proteomics (MSP) at the University (G. Nelsestuen, P.I.). Major activities include new instrumentation to be installed at the U of M while enhanced bioinformatics platforms will be developed at the Mayo Clinic and coordinated through the Minnesota Supercomputer Institute (MSI).
A research grant was awarded to the joint kidney transplant centers at the U of M and the Mayo (William Oetting and Fernando Cosio, P.I.) "Biomarkers of Acute Transplant Rejection." A substantial component of this project deals with proteomic biomarkers to be developed at the MSP. |
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