We are studying various DNA rearrangement systems relevant to human health including resolution of a concatenated DNA-replication intermediate into linear chromosomes in Borrelia burgdorferi, the Lyme disease spirochete and retroviral integration reaction in which the integrase protein e
David A. Bernlohr, Distinguished McKnight Professor and Head, Cargill Chair in Systems Biology of Human Metabolism
A major research study in the laboratory focuses on the metabolic relationships between obesity and insulin action. Our laboratory specifically examines cytoplasmic fatty acid binding proteins and their role(s) in mediating fatty acid metabolism in adipocytes and macrophages, particularly le
The Bielinsky lab is interested in DNA replication-coupled repair pathways and genetic networks that maintain genome stability. In addition, we seek to identify cancer specific vulnerabilities and exploit them for therapy.
We have developed highly efficient mass-spectrometry based technology for system-wide identification and quantification of PTM sites and established the bioinformatics platform for understanding the functional relevance of the PTMs in protein structure and cellular physiology.
Peter Crawford, Professor; Director of Division of Molecular Medicine, Department of Medicine
We develop and deploy metabolomics technologies to reveal the roles of intermediary and lipid metabolism in integrated physiological homeostasis using both genetically engineered mice and human subjects.
Our Lab investigates the mechanisms by which biological molecules evolve, the molecular basis of their functions, and develop methods for their engineering, with the aim of developing efficient, soft solutions to current or emerging society issues.
Our objective is to fully define the function of dystrophin in striated muscle to understand how its absence or abnormality leads to the pathologies observed in Duchenne and Becker muscular dystrophies. Our unique approach integrates biochemical and biophysical analyses of the very large dystrop