Our work focuses on the discovery and heterologous expression of pathways and genes involved in the biosynthesis of metabolites from unique microbial sources.
Aaron Goldstrohm, Professor; Director of Graduate Studies, BMBB Graduate Program
Our goal is to discover the principles and mechanisms that control expression of genes, with the benefit to society that this knowledge will enhance our understanding of the causes of disease and advance therapeutic strategies to correct deleterious gene expression.
Our lab is interested in how cell surface receptors convert signals from extracellular stimuli like mechanical force into a biological response, as dysregulation in a cell’s force-sensing ability can lead to disease.
The Harris Lab uses a large repertoire of model systems and experimental approaches to understand how DNA mutating enzymes (APOBECs) provide immunity against viral infections, yet in many cases also contribute to tumor evolution through genomic DNA mutagenesis.
Biocatalysis uses enzymes for unnatural purposes - synthesis of drugs, chemical intermediates & biofuels. Using enzymes creates more efficient syntheses that minimize pollution and avoid toxic and non-selective chemical reagents.
We are interested in understanding the molecular networks that coordinate nutrient metabolism and cell growth. How cells assess nutrient- or energy states and relay this information into appropriate decisions on growth is poorly understood.
Every biological process is regulated by several different control mechanisms. Our research focuses on how the individual mechanisms work and how they are coordinated with each other. We are studying the regulation of the glyoxylate bypass in the bacterium Escherichia coli.