Bollum Symposium

19th Annual Bollum Symposium | Versatile Functions of RNA in Biology and Disease

1:00-5:00 pm on Wednesday, May 3, 2017

Mayo Auditorium, Minneapolis Campus

No Registration Necessary

Sponsored by: Department of Biochemistry, Molecular Biology, and Biophysics, The Frederick James Bollum Endowed Research Fund for Biochemistry


Speakers:

Hashim Al Hashima, PhD, Duke University

Lynne Maquat, PhD, University of Rochester

Kristen Lynch, PhD, University of Pennsylvania

Maurice Swanson, PhD, University of Flordia


Schedule

1:00pm     Welcome

                   Dr. David Bernlohr, University of Minnesota-Twin Cites

1:05pm     Introduction

                   Dr. Aaron Goldstrohm, University of Minnesota-Twin Cities

1:15pm     Dr. Hashim Al-Hashimi, Duke University

                   Dynamic RNA Structures in Transitional Fidelity and Drug History

2:00pm     Dr. Lynne Maquat, University of Rochester

                   Nonsense-mediated mRNA Decay and Human Disease: Genome Guardian and Executor

2:45pm     Intermission

3:15pm     Dr. Kristen Lynch, University of Pennsylvania

                   Getting Sick of Splicing: Alternative Splicing and the Humane Immune System

4:00pm     Dr. Maurice Swanson, University of Flordia

                   RNA-mediated Mechanisms in Development and Disease

4:45pm     Closing Remarks

                   Dr. Aaron Goldstrohm, University of Minnesota-Twin Cities


Background for the Frederick J. Bollum Endowed Research Fund for Biochemistry Lectureship Series

Frederick J. Bollum received a B.A. in Zoology in 1949 and a Ph.D. in Physiological Chemistry in 1956 from the University of Minnesota. He went on to a Postdoctoral Fellowship at the Universtiy of Wisconsin and then took a position at Oak Ridge National Laboratory in Tennessee. Later, he became a Professor of Biochemistry at the University of Kentucky Medical School, in Lexington, KY and then Chairman of Biochemistry at Uniformed Services University for the Health Sciences, Bethesda, MD. He then moved on to become President and CEO of Supertechs, Inc., Biotechnology Consultants. His major research interests were nucleic acid chemistry and enzymology, nucleotide metabolism, genetic aspects of biochemistry, immunological diversification and recombinant DNA, authoring more than 260 papers and three books.

Dr. Bollum regularly contributes to the Department of Biochemistry, Molecular Biology and Biophysics through the Minnesota Medical Foundation. His gifts have helped support lectures, research, graduate student awards and meeting opportunities and an annual symposium on cutting edge research topics.


Archive

Year/Topic
Speaker/Affiliation
Titles

2016

Therapeutic Proteins: a Protein Engineering Perspecitve

(Poster)

Dr. Jonathan Dordick (Ph.D., 1986)

Dr. Joanna Swain (Ph.D., 1997)

Dr. Eric Gaucher (Ph.D., 2001)

Dr. Hans Erickson (Ph.D., 1999)

"Biomolecular engineering as an emerging paradigm for advancing medicine"

"In vitro selection coupled with NGS in therapeutic protein discovery at Bristol-Myers Squibb"

"Engineering ancient proteins for biotherapeutic development"

"Building better antibody-drug conjugates for the treatment of cancer"

2015

Biochemistry Centennial Celebration

(Poster)

Dr. Hung-Ying Kao (Ph.D., 1995)

Dr. Amy Rocklin (Ph.D., 2000)

Dr. Venkateswarlu Pothapragada (Ph.D., 1962)

Dr. Brad Wallar (Ph.D., 2000)

Dr. Rebecca Moen (Ph.D., 2013)

Dr. Melanie Simpson (Ph.D., 1997)

"Identification of Prp40, a Novel Essential Yeast Splicing Factor Associated With the U1 snRNP"

"Structural and Mechanistic Studies of 1-Aminocyclopropane-1-Carboxylic Acid Oxidase"

"Studies on Fluoride Metabolism and Transport"

"Probing The Interactions Between Component B and The Hydroxylase Of Methane Monooxygenase"

"Site-directed Modifications of Myosin"

"Biochemical and Physiological Analysis of the Adipocyte Lipid-binding Protein"

2014

The dynamic microbiome

Jose Carlos Clemente, PhD

Mount Sinai School of Medicine

Lawrence David, PhD

Duke University

Dan Knights, PhD

University of Minnesota-Twin Cities

Michael Sadowsky

University of Minnesota-Twin Cities

"From population studies to inflammation and cancer: the microbiome in health and disease"

"Perturbing Human Microbiota"

"Linking microbiome structure and function to host phenotype and genotype"

"Use of Fecal Microbiota Therapeutics to Treat and Understand Intestinal Dysbiosis"

2013

Discovery Metabolomics

Oliver Fiehn, PhD

University of California, Davis

Ayyalusamy Ramamoorthy, PhD

University of Michigan

Jared Rutter, PhD

University of Utah School of Medicine

Gary Siuzdak, PhD

The Scripps Research Institute

"The NIH West Coast Metabolomics Center: Integrating metabolomics with genomic data"

"NMR-based Metabolomics for Cancer Biomarker Discovery"

"The Integrated Regulation of Metabolism"

"Mass Spectrometry-Based Global Metabolomics for Understanding Disease Pathogenesis"

2012

Structure, Motion, Biomarkers: Discovery through NMR

(Poster)

Prof. Dorothee Kern, Brandeis University

Prof. Jeremy K. Nicholson, Imperial College, London

Prof. Chad M. Rienstra, University of Illinois

Prof. Gerhard Wagner, Harvard University

Choreographing an enzyme's dance-dynamics during catalysis

Spectroscopy and Stratified Medicine: Getting Systems Biology into the Clinic

Taking solid-state NMR to extremes: membrane proteins, fibrils, new methods

New NMR experiments for challenging proteins

2011

Biophysics of Nucleic Acid-Protein Interactions

(Poster)

Dr. Michael Fried, University of Kentucky, Lexington, KY

Dr. Ioulia Rouzina, University of Minnesota, Minneapolis, MN

Dr. Phillip A. Sharp, Massachusetts Institute of Technology, Cambridge, MA

Dr. Mark C. Williams, Northeastern University, Boston, MA

O6 Alkylguanine-DNA Alkyltransferase. New Functions For A Guardian of the Genome.

Bloomfield-Inspired Biophysics in HIV Research

From Biophysics to RNA Biology

Mechanochemistry of DNA binding: From small molecules to proteins

2010

Unconventional Nucleic Acid Biology
(Poster)

Dr. Brenda Bass, University of Utah, Salt Lake City, UT

Dr. Ronald Breaker, Yale University, New Haven, CT

Dr. Simon Wain-Hobson, Pasteur Institute, Paris, France

Dr. Michael Neuberger, University of Cambridge, Cambridge, UK

Toward a mechanistic understanding of Dicer's different roles in processing dsRNA.

Riboswitches- Molecular Relics from the RNA World?

 

The pros and cons of viral hypermutation.

 

Antibody diversification through DNA deamination.

2009

The Biochemistry of Biofuels
(Poster)

 

Dr. Timothy Donohue, University of Wisconsin-Madison

Dr. Jay Keasling, University of California, Berkeley

Dr. James C. Liao, University of California, Los Angeles

Dr. Stephen Ragsdale, University of Michigan, Ann Arbor

Tapping into Microbial Genomes for Light-driven Hydrogen Production.

Engineering Microorganisms for Production of Advanced Biofuels.

Fuels and Chemical Beyond Petroleum.

Nickel Enzymes in the Biochemistry of Biofuels.

 

2008

Circadian Clocks
(Poster)

Dr. Steve A. Kay, University of California, San Diego

Dr. Amita Sehgal, HHMI/ University of Pennsylvania Medical School

Dr. Joseph S. Takahashi, HHMI/Northwestern University

Dr. Ying-Hui Fu, University of California, San Francisco

Network Discovery Pipelines for Circadian Clocks.

Molecular Biology of Circadian Rhythms in Drosophila.

Genetic Analysis of Circadian Clocks in Mammals.

Molecular Characterization of Human Sleep Variants.

2007

Reguating Biological Function by Ubiquitination

Dr. Rachel Klevit, University of Washington, Seattle, WA


Dr. Keith D. Wilkinson, Emory University School of Medicine, Atlanta, GA

Dr. Daniel Finley, Harvard Medical School, Boston, MA

Dr. Randy Hampton, University of California, San Diego, La Jolla, CA

Recognition and Disassembly of the Polyubiquitin Targeting Signal.

Structural Insights into Diversity and specificity in Protein Ubiquitination.

Regulation of Protasome Activity.

Protein Quality Control in Cell Regulation.

2006

The Science of Aging

Dr. Leonard P. Guarante, MIT, Boston

Dr. Holly Van Remmen, University of Texas, San Antonio

Dr. Richard A. Miller, University of Michigan

Dr. Richard Weindruch, University of Wisconsin

SIR2, Calorie Restriction and Aging

Fifty Years of the Oxidative Stress Theory of Aging: Where Are We Now? Fifty Years of the Oxidative Stress Theory of Aging: Where Are We Now?

Size, Stress, and Aging: Lessons from Dwarf Mice

Caloric Restriction and Aging: Studies in Mice and Monkeys

2005

Computational Biochemistry and Molecular Biology

Dr. Eric D. Siggia, Rockefeller University in New York

Dr. Peter D. Karp, Stanford Research Institute International (SRI), Palo Alto (CA)

Dr. Michael A. Savageau, University California, Davis.

Dr. Jiali Gao, University of Minnesota

Computation Approaches to Blastoderm Patterning in the Fly and its Evolution.

Databases and Algorithms for Pathway Bioinformatics.

System Design Principles and Construction of Gene Circuits

Dynamics, Pathways, and Tunneling: A Computational Perspective of Enzyme Catalysis

2004

Proteomics: Advancing Our Understanding of Biology

 

Michel Desjardins, Université de Montréal

Tim Haystead,Duke University Medical Center

Kathryn E. Howell
University of Colorado School of Medicine, Denver

Bradford W. Gibson
Buck Institute of Aging Research

Proteomics Brings New Paradigms to Immunology

Proteome Mining Drug and Target Discovery en Masse.

New Insights into Golgi Function Through Proteomics

The Mitochondrial Proteome, Neurodegenerative Disease and Aging

2003

Structural Dymamics of Membrane Signal Transduction

 

Dr. Wayne Hubbell, Jules Stein Eye Institute, UCLA

Dr. Lynmarie Thompson, University of Massachusetts, Amherst

Dr. John Spudich, University of Texas, Houston

Dr. David Farrens, Oregon Health and Science University

A nitroxide's view of rhodopsin structure, dynamics and activation

Site-directed solid-state NMR probing transmembrane signaling mechanisms in bacterial chemoreceptors.

Microbial rhodopsins: structure/function in ion transport and signaling.

Conformational changes in G-protein coupled receptors: insights gained from site-directed fluorescence studies.

2002

Nature's Copier: the DNA Replication Machinery

Dr. Melvin DePamphilis, National Institute of Child Health and Human Development

Dr. Bik-Kwoon Tye, Cornell University


Dr. James Berger, University of California, Berkeley

The ORC Cycle: a Novel Mechanism for Regulating Eukaryotic DNA Replication

Coordination of Genome Expression and DNA Replication in Proliferating Cells: The Multiple Roles of the MCM Proteins in Eukaryotes

Toward a Structural Understanding of DNA Replication Initiation

2001

Directed Evolution of Biomolecules & Functional Genomics

Dr. Jeremy Minshull, Maxygen

Dr. Karl Dane Wittrup, Massachusetts Institute of Technology

Dr. George Georgiou, University of Texas

 

Biological Diversity: From Nature and Beyond.

Engineering Protein Recognition, Stability, and Expression by Yeast Display

Functional Expression of Multidisulfide Proteins in
Bacteria: Genetic, Biochemical, Structural Biology and Directed Evolution Strategies.

2000

G Protein-Coupled Signaling

Nigel Bunnett, University of California, San Francisco

Linda Hicke, Northwestern University

John Tesmer, University of Texas


David Clapham, Harvard Medical School

How Proteases Talk to Cells:   A Comparison of Signaling by Proteases and Neuropeptides

Role of Ubiquitin in Signaling Receptor Downregulation

Effector Regulation by Heterotrimeric G   Proteins:   Lessons Learned from Adenyl Cyclase

Protein Gated Potassium Channels

1999

Transcription Factors & Metabolic Control

Gretchen J. Darlington, Baylor College of Medicine

Steven A. Kliewer, Glaxo-Wellcome Research & Development

Timothy S. Osborne, University of California, Irvine

The Role of C/EBP Proteins in Integratie Metabolism

PPARs and PXR: Orphan Nuclear Receptors that Define Novel Hormone Signaling Pathways.

Positive and Negative Regulation of Genes that Regulate Cholesterol Metabolism.