Coupling Metabolism & Protein Post-translational Modifications
1-5 p.m. - Wednesday, May 1, 2019
2-137 Jackson Hall, Minneapolis Campus
No Registration Necessary
Sponsored by: Department of Biochemistry, Molecular Biology, and Biophysics and The Frederick James Bollum Endowed Research Fund for Biochemistry
Dr. Yingming Zhao, University of Chicago
Dr. Sumin Kang, Emory University
Dr. Hening Lin, Cornell University
Dr. Kathryn Wellen, University of Pennsylvania
1:00 p.m.: Dr. David Bernlohr - Welcome
1:05 p.m.: Dr. Doug Mashek - Introduction
1:10 p.m.: Dr. Yingming Zhao - A new paradigm of epigenetic regulation linking cell. metab. to histone marks
2:00 p.m.: Dr. Sumin Kang - Phosphorylation in metabolic signaling and cancer progression
2:50 p.m.: Break
3:20 p.m.: Dr. Hening Lin - Regulatory roles of metabolites
4:10 p.m.: Dr. Kathryn Wellen - Acetyl-CoA metabolism in chromatin regulation and tumorigenesis
5:00 p.m.: End of symposium
Background for the Frederick J. Bollum Endowed Research Fund for Biochemistry Lectureship Series
Frederick J. Bollum received a B.A. in Zoology in 1949 and a Ph.D. in Physiological Chemistry in 1956 from the University of Minnesota. He went on to a Postdoctoral Fellowship at the Universtiy of Wisconsin and then took a position at Oak Ridge National Laboratory in Tennessee. Later, he became a Professor of Biochemistry at the University of Kentucky Medical School, in Lexington, KY and then Chairman of Biochemistry at Uniformed Services University for the Health Sciences, Bethesda, MD. He then moved on to become President and CEO of Supertechs, Inc., Biotechnology Consultants. His major research interests were nucleic acid chemistry and enzymology, nucleotide metabolism, genetic aspects of biochemistry, immunological diversification and recombinant DNA, authoring more than 260 papers and three books.
Dr. Bollum regularly contributes to the Department of Biochemistry, Molecular Biology and Biophysics through the Minnesota Medical Foundation. His gifts have helped support lectures, research, graduate student awards and meeting opportunities and an annual symposium on cutting edge research topics.
Brenton Hoffman, PhD, Duke University
Marcos Sotomayor, PhD, Ohio State University
Matt Lang, PhD, Vanderbilt University
Arpita Upadhyaya, PhD, University of Maryland
Scott Manalis, PhD, Massachusetts Institute of Technology
"Assessing the effects of protein load on protein function"
"Molecular mechanics of hearing"
"Single molecule drivers of αβ T cell recognition"
"Cytoskeletal dynamics of mechanosensing in immune cells"
"Non-invasive monitoring of single-cell mechanics"
Versatile Functions of RNA in Biology and Disease
University of Rochester
University of Pennsylvania
University of Flordia
"Dynamic RNA Structures in Translational Fidelity and Drug Discovery"
"Nonsense-mediated mRNA Decay and Human Disease: Genome Guardian and Executor"
"Getting Sick of Splicing: Alternative Splicing and the Human Immune System"
"RNA-mediated Mechanisms in Development and Disease"
Therapeutic Proteins: a Protein Engineering Perspective
Center for Biotechnology & Interdisciplinary Studies
Joanna Swain, Ph.D.
Parker H. Petit Instuitute for Bioengineering & Bioscience
Hans Erickson, Ph. D.
"Biomolecular engineering as an emerging paradigm for advancing medicine"
"In vitro selection coupled with NGS in therapeutic protein discovery at Bristol-Myers Squibb"
"Engineering ancient proteins for biotherapeutic development"
"Building better antibody-drug conjugates for the treatment of cancer"
Biochemistry Centennial Celebration
Dr. Hung-Ying Kao (Ph.D., 1995)
Dr. Amy Rocklin (Ph.D., 2000)
Dr. Venkateswarlu Pothapragada (Ph.D., 1962)
Dr. Brad Wallar (Ph.D., 2000)
Dr. Rebecca Moen (Ph.D., 2013)
Dr. Melanie Simpson (Ph.D., 1997)
"Identification of Prp40, a Novel Essential Yeast Splicing Factor Associated With the U1 snRNP"
"Structural and Mechanistic Studies of 1-Aminocyclopropane-1-Carboxylic Acid Oxidase"
"Studies on Fluoride Metabolism and Transport"
"Probing The Interactions Between Component B and The Hydroxylase Of Methane Monooxygenase"
"Site-directed Modifications of Myosin"
"Biochemical and Physiological Analysis of the Adipocyte Lipid-binding Protein"
The dynamic microbiome
Mount Sinai School of Medicine
University of Minnesota-Twin Cities
University of Minnesota-Twin Cities
"From population studies to inflammation and cancer: the microbiome in health and disease"
"Perturbing Human Microbiota"
"Linking microbiome structure and function to host phenotype and genotype"
"Use of Fecal Microbiota Therapeutics to Treat and Understand Intestinal Dysbiosis"
University of California, Davis
University of Michigan
University of Utah School of Medicine
The Scripps Research Institute
"The NIH West Coast Metabolomics Center: Integrating metabolomics with genomic data"
"NMR-based Metabolomics for Cancer Biomarker Discovery"
"The Integrated Regulation of Metabolism"
"Mass Spectrometry-Based Global Metabolomics for Understanding Disease Pathogenesis"
Structure, Motion, Biomarkers: Discovery through NMR
Choreographing an enzyme's dance-dynamics during catalysis
Spectroscopy and Stratified Medicine: Getting Systems Biology into the Clinic
Taking solid-state NMR to extremes: membrane proteins, fibrils, new methods
New NMR experiments for challenging proteins
Biophysics of Nucleic Acid-Protein Interactions
Dr. Michael Fried, University of Kentucky, Lexington, KY
Dr. Ioulia Rouzina, University of Minnesota, Minneapolis, MN
Dr. Phillip A. Sharp, Massachusetts Institute of Technology, Cambridge, MA
Dr. Mark C. Williams, Northeastern University, Boston, MA
O6 Alkylguanine-DNA Alkyltransferase. New Functions For A Guardian of the Genome.
Bloomfield-Inspired Biophysics in HIV Research
From Biophysics to RNA Biology
Mechanochemistry of DNA binding: From small molecules to proteins
Unconventional Nucleic Acid Biology
Dr. Brenda Bass, University of Utah, Salt Lake City, UT
Dr. Ronald Breaker, Yale University, New Haven, CT
Dr. Simon Wain-Hobson, Pasteur Institute, Paris, France
Dr. Michael Neuberger, University of Cambridge, Cambridge, UK
Toward a mechanistic understanding of Dicer's different roles in processing dsRNA.
Riboswitches- Molecular Relics from the RNA World?
The pros and cons of viral hypermutation.
Antibody diversification through DNA deamination.
The Biochemistry of Biofuels
Dr. Timothy Donohue, University of Wisconsin-Madison
Dr. Jay Keasling, University of California, Berkeley
Dr. James C. Liao, University of California, Los Angeles
Dr. Stephen Ragsdale, University of Michigan, Ann Arbor
Tapping into Microbial Genomes for Light-driven Hydrogen Production.
Engineering Microorganisms for Production of Advanced Biofuels.
Fuels and Chemical Beyond Petroleum.
Nickel Enzymes in the Biochemistry of Biofuels.
Dr. Steve A. Kay, University of California, San Diego
Dr. Amita Sehgal, HHMI/ University of Pennsylvania Medical School
Dr. Joseph S. Takahashi, HHMI/Northwestern University
Dr. Ying-Hui Fu, University of California, San Francisco
Network Discovery Pipelines for Circadian Clocks.
Molecular Biology of Circadian Rhythms in Drosophila.
Genetic Analysis of Circadian Clocks in Mammals.
Molecular Characterization of Human Sleep Variants.
Reguating Biological Function by Ubiquitination
Dr. Rachel Klevit, University of Washington, Seattle, WA
Recognition and Disassembly of the Polyubiquitin Targeting Signal.
Structural Insights into Diversity and specificity in Protein Ubiquitination.
Regulation of Protasome Activity.
The Science of Aging
Dr. Leonard P. Guarante, MIT, Boston
Dr. Holly Van Remmen, University of Texas, San Antonio
SIR2, Calorie Restriction and Aging
Fifty Years of the Oxidative Stress Theory of Aging: Where Are We Now? Fifty Years of the Oxidative Stress Theory of Aging: Where Are We Now?
Size, Stress, and Aging: Lessons from Dwarf Mice
Caloric Restriction and Aging: Studies in Mice and Monkeys
Computational Biochemistry and Molecular Biology
Dr. Eric D. Siggia, Rockefeller University in New York
Computation Approaches to Blastoderm Patterning in the Fly and its Evolution.
Databases and Algorithms for Pathway Bioinformatics.
System Design Principles and Construction of Gene Circuits
Dynamics, Pathways, and Tunneling: A Computational Perspective of Enzyme Catalysis
Proteomics: Advancing Our Understanding of Biology
Michel Desjardins, Université de Montréal
Tim Haystead,Duke University Medical Center
Kathryn E. Howell
Bradford W. Gibson
Proteomics Brings New Paradigms to Immunology
New Insights into Golgi Function Through Proteomics
The Mitochondrial Proteome, Neurodegenerative Disease and Aging
Structural Dymamics of Membrane Signal Transduction
Dr. Wayne Hubbell, Jules Stein Eye Institute, UCLA
Dr. Lynmarie Thompson, University of Massachusetts, Amherst
Dr. John Spudich, University of Texas, Houston
Dr. David Farrens, Oregon Health and Science University
A nitroxide's view of rhodopsin structure, dynamics and activation
Site-directed solid-state NMR probing transmembrane signaling mechanisms in bacterial chemoreceptors.
Microbial rhodopsins: structure/function in ion transport and signaling.
Conformational changes in G-protein coupled receptors: insights gained from site-directed fluorescence studies.
Nature's Copier: the DNA Replication Machinery
Dr. Melvin DePamphilis, National Institute of Child Health and Human Development
Dr. Bik-Kwoon Tye, Cornell University
The ORC Cycle: a Novel Mechanism for Regulating Eukaryotic DNA Replication
Coordination of Genome Expression and DNA Replication in Proliferating Cells: The Multiple Roles of the MCM Proteins in Eukaryotes
Toward a Structural Understanding of DNA Replication Initiation
Directed Evolution of Biomolecules & Functional Genomics
Dr. Jeremy Minshull, Maxygen
Dr. Karl Dane Wittrup, Massachusetts Institute of Technology
Dr. George Georgiou, University of Texas
Biological Diversity: From Nature and Beyond.
Engineering Protein Recognition, Stability, and Expression by Yeast Display
Functional Expression of Multidisulfide Proteins in
G Protein-Coupled Signaling
Nigel Bunnett, University of California, San Francisco
Linda Hicke, Northwestern University
John Tesmer, University of Texas
How Proteases Talk to Cells: A Comparison of Signaling by Proteases and Neuropeptides
Role of Ubiquitin in Signaling Receptor Downregulation
Effector Regulation by Heterotrimeric G Proteins: Lessons Learned from Adenyl Cyclase
Protein Gated Potassium Channels
Transcription Factors & Metabolic Control
Gretchen J. Darlington, Baylor College of Medicine
Timothy S. Osborne, University of California, Irvine
The Role of C/EBP Proteins in Integratie Metabolism
PPARs and PXR: Orphan Nuclear Receptors that Define Novel Hormone Signaling Pathways.
Positive and Negative Regulation of Genes that Regulate Cholesterol Metabolism.