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Bollum Symposium

<h2><u>20th Annual Bollum Symposium | Mechanobiology</u></h2><p><!--StartFragment--><strong>1:00-5:00 pm on </strong><strong>Wednesday, May 2, 2018</strong></p><p><strong>Mayo Auditorium, Minneapolis Campus</strong></p><p><em>No Registration Necessary</em></p><p>Sponsored by: Department of Biochemistry, Molecular Biology, and Biophysics, The Frederick James Bollum Endowed Research Fund for Biochemistry, and Physical Sciences of Oncology</p><hr><h2>Speakers:</h2><p><strong><a href="http://bme.duke.edu/faculty/brenton-hoffman">Brenton Hoffman, PhD</a>, Duke University</strong></p><p><strong><a href="https://chemistry.osu.edu/people/sotomayor.8">Marcos Sotomayor, PhD</a>, Ohio State University</strong></p><p><strong><a href="https://engineering.vanderbilt.edu/bio/matthew-lang">Matt Lang, PhD</a>, Vanderbilt University</strong></p><p><strong><a href="https://umdphysics.umd.edu/people/faculty/current/item/544-arpitau.html"... Upadhyaya, PhD</a>, University of Maryland</strong></p><p><strong><a href="https://be.mit.edu/directory/scott-manalis">Scott Manalis, PhD</a>, Massachusetts Institute of Technology </strong></p><p>[[{"fid":"39426","view_mode":"default","fields":{"format":"default","alignment":"","field_file_image_alt_text[und][0][value]":false,"field_file_image_title_text[und][0][value]":false,"external_url":""},"link_text":null,"type":"media","field_deltas":{"3":{"format":"default","alignment":"","field_file_image_alt_text[und][0][value]":false,"field_file_image_title_text[und][0][value]":false,"external_url":""}},"attributes":{"height":615,"width":469,"class":"media-element file-default","data-delta":"3"}}]]</p><hr><h2>Schedule</h2><p>1:00pm &nbsp;&nbsp; &nbsp; &nbsp;&nbsp; &nbsp;&nbsp; <a href="https://cbs.umn.edu/contacts/david-bernlohr-0">Dr. David Bernlohr</a> and <a href="https://cbs.umn.edu/contacts/wendy-gordon">Dr. Wendy Gordon</a> Introduction</p><p>1:10pm:&nbsp;&nbsp;&nbsp; &nbsp; &nbsp; &nbsp;&nbsp; <a href="http://bme.umn.edu/people/faculty/odde.html">Dr. David Odde</a> Introduction</p><p>1:15pm:&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp; &nbsp;&nbsp; <a href="http://bme.duke.edu/faculty/brenton-hoffman">Dr. Brenton Hoffman</a></p><p>1:55pm:&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp; <a href="http://chemistry.osu.edu/people/sotomayor.8">Dr. Marcos Sotomayor</a></p><p>2:35pm: &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <a href="http://engineering.vanderbilt.edu/bio/matthew-lang">Dr. Matt Lang</a></p><p>3:15pm:&nbsp;&nbsp; &nbsp;&nbsp; &nbsp;&nbsp; &nbsp; Intermission</p><p>3:40pm:&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; &nbsp; &nbsp; <a href="http://umdphysics.umd.edu/people/faculty/current/item/544-arpitau.html">Dr. Arpita Upadhyaya</a></p><p>4:20pm:&nbsp;&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; <a href="http://be.mit.edu/directory/scott-manalis">Dr. Scott Manalis</a></p><p>&nbsp;</p><hr><h2>Background for the&nbsp;Frederick J. Bollum Endowed Research Fund for Biochemistry Lectureship Series</h2><p>Frederick J. Bollum received a B.A. in Zoology in 1949 and a Ph.D. in Physiological Chemistry in 1956 from the University of Minnesota. He went on to a Postdoctoral Fellowship at the Universtiy of Wisconsin and then took a position at Oak Ridge National Laboratory in Tennessee. Later, he became a Professor of Biochemistry at the University of Kentucky Medical School, in Lexington, KY and then Chairman of Biochemistry at Uniformed Services University for the Health Sciences, Bethesda, MD. He then moved on to become President and CEO of Supertechs, Inc., Biotechnology Consultants. His major research interests were nucleic acid chemistry and enzymology, nucleotide metabolism, genetic aspects of biochemistry, immunological diversification and recombinant DNA, authoring more than 260 papers and three books.<br><br>Dr. Bollum regularly contributes to the Department of Biochemistry, Molecular Biology and Biophysics through the Minnesota Medical Foundation. His gifts have helped support lectures, research, graduate student awards and meeting opportunities and an annual symposium on cutting edge research topics.</p><hr><h3>Archive</h3><table border="1" cellpadding="0" cellspacing="0" style="width: 100%;"><tbody><tr><td><h5><strong>Year/Topic</strong></h5></td><td><h5><strong>Speaker/Affiliation</strong></h5></td><td><h5><strong>Titles</strong></h5></td></tr><tr><td><h4>2017</h4><p>Versatile Functions of RNA in Biology and Disease</p><p>(<a href="https://cbs.umn.edu/sites/cbs.umn.edu/files/public/downloads/2017%20Boll...)</p></td><td><p>&nbsp;</p><p><a href="http://www.biochem.duke.edu/hashim-m-al-hashimi-primary">Hashim AL Hashikmi, Ph.D.</a></p><p>Duke University</p><p><a href="http://www.urmc.rochester.edu/labs/maquat-lab/contact.aspx">Lynne Maquat, Ph.D.</a></p><p>University of Rochester</p><p><a href="http://www.kwlynchlab.org/">Kristen Lynch, Ph.D.</a></p><p>University of Pennsylvania</p><p><a href="http://neurogenetics.med.ufl.edu/faculty/dr-maurice-swanson/">Maurice Swanson, Ph.D.</a></p><p>University of Flordia</p></td><td><p>"Dynamic RNA Structures in Translational Fidelity and Drug Discovery"</p><p>"Nonsense-mediated mRNA Decay and Human Disease: Genome Guardian and Executor"</p><p>"Getting Sick of Splicing: Alternative Splicing and the Human Immune System"</p><p>"RNA-mediated Mechanisms in Development and Disease"</p></td></tr><tr><td><h4>2016</h4><p>Therapeutic Proteins: a Protein Engineering Perspective</p><p>(<a href="https://cbs.umn.edu/sites/cbs.umn.edu/files/public/downloads/Bollum%20Sy... color="#0066cc">Poster</font></u></a>)</p></td><td><p><a href="https://www.rpi.edu/dept/bio/faculty/profiles/dordick.html">Jonathan Dordick, Ph.D.</a></p><p>Center for Biotechnology &amp; Interdisciplinary Studies</p><p>Joanna Swain, Ph.D.</p><p>Bristol-Myers Squibb</p><p><a href="http://www.gauchergroup.biology.gatech.edu/index.html">Eric Gaucher, Ph.D.</a></p><p>Parker H. Petit Instuitute for Bioengineering &amp; Bioscience</p><p>Hans Erickson, Ph. D.</p><p>Genentech</p></td><td><p>"Biomolecular engineering as an emerging paradigm for advancing medicine"</p><p>"In vitro selection coupled with NGS in therapeutic protein discovery at Bristol-Myers Squibb"</p><p>"Engineering ancient proteins for biotherapeutic development"</p><p>"Building better antibody-drug conjugates for the treatment of cancer"</p></td></tr><tr><td><h4>2015</h4><p>Biochemistry Centennial Celebration</p><p>(<a href="/sites/cbs.umn.edu/files/public/downloads/2015 Poster 8 x 11.5 with Registration Link.pdf">Poster</a>)</p></td><td><p>Dr. Hung-Ying Kao (Ph.D., 1995)</p><p>Dr. Amy Rocklin (Ph.D., 2000)</p><p>Dr. Venkateswarlu Pothapragada (Ph.D., 1962)</p><p>Dr. Brad Wallar (Ph.D., 2000)</p><p>Dr. Rebecca Moen (Ph.D., 2013)</p><p>Dr. Melanie Simpson (Ph.D., 1997)</p></td><td><p>"Identification of Prp40, a Novel Essential Yeast Splicing Factor Associated With the U1 snRNP"</p><p>"Structural and Mechanistic Studies of 1-Aminocyclopropane-1-Carboxylic Acid Oxidase"</p><p>"Studies on Fluoride Metabolism and Transport"</p><p>"Probing The Interactions Between Component B and The Hydroxylase Of Methane Monooxygenase"</p><p>"Site-directed Modifications of Myosin"</p><p>"Biochemical and Physiological Analysis of the Adipocyte Lipid-binding Protein"</p></td></tr><tr><td><h4>2014</h4><p>The dynamic microbiome</p></td><td><p><a href="http://www.clementelab.org/">Jose Carlos Clemente, PhD</a></p><p>Mount Sinai School of Medicine</p><p><a href="http://el.ladlab.org:8080/">Lawrence David, PhD</a></p><p>Duke University</p><p><a href="http://www.knightslab.org/">Dan Knights, PhD</a></p><p>University of Minnesota-Twin Cities</p><p><a href="http://www.bti.umn.edu/faculty/biosadowsky.html">Michael Sadowsky,</a></p><p>University of Minnesota-Twin Cities</p></td><td><p>"From population studies to inflammation and cancer: the microbiome in health and disease"</p><p>"Perturbing Human Microbiota"</p><p>"Linking microbiome structure and function to host phenotype and genotype"</p><p>"Use of Fecal Microbiota Therapeutics to Treat and Understand Intestinal Dysbiosis"</p></td></tr><tr><td><h4>2013</h4><p>Discovery Metabolomics</p></td><td><p><a href="http://www.genomecenter.ucdavis.edu/people/fiehn">Oliver Fiehn, PhD </a></p><p>University of California, Davis</p><p><a href="https://www.chem.lsa.umich.edu/chem/faculty/facultyDetail.php?Uniqname=r... Ramamoorthy, PhD </a></p><p>University of Michigan</p><p><a href="http://medicine.utah.edu/faculty/mddetail.php?facultyID=u0406506">Jared Rutter, PhD</a></p><p>University of Utah School of Medicine</p><p><a href="http://masspec.scripps.edu/personnel/director.php">Gary Siuzdak, PhD</a></p><p>The Scripps Research Institute</p></td><td><p>"The NIH West Coast Metabolomics Center: Integrating metabolomics with genomic data"</p><p>"NMR-based Metabolomics for Cancer Biomarker Discovery"</p><p>"The Integrated Regulation of Metabolism"</p><p>"Mass Spectrometry-Based Global Metabolomics for Understanding Disease Pathogenesis"</p></td></tr><tr><td><h4>2012</h4><p>Structure, Motion, Biomarkers: Discovery through NMR</p><p>(<a href="/sites/cbs.umn.edu/files/public/downloads/Bollum-2012-Final.pdf">Poster</a>)</p></td><td><div><p><a href="http://www.bio.brandeis.edu/kernlab/people/pi.html">Prof. Dorothee Kern</a>, Brandeis University</p><p><a href="http://www1.imperial.ac.uk/medicine/people/j.nicholson/">Prof. Jeremy K. Nicholson</a>, Imperial College, London</p><div><p><a href="http://chemistry.illinois.edu/faculty/Chad_Rienstra.html">Prof. Chad M. Rienstra</a>, University of Illinois</p><p><a href="http://gwagner.med.harvard.edu/">Prof. Gerhard Wagner</a>, Harvard University</p></div></div></td><td><p>Choreographing an enzyme's dance-dynamics during catalysis</p><p>Spectroscopy and Stratified Medicine: Getting Systems Biology into the Clinic</p><p>Taking solid-state NMR to extremes: membrane proteins, fibrils, new methods</p><p>New NMR experiments for challenging proteins</p></td></tr><tr><td><h4>2011</h4><p>Biophysics of Nucleic Acid-Protein Interactions</p><p>(<a href="https://www.cbs.umn.edu/sites/cbs.umn.edu/files/public/downloads/Bollum%...)</p></td><td><p>Dr. Michael Fried, University of Kentucky, Lexington, KY</p><p>Dr. Ioulia Rouzina, University of Minnesota, Minneapolis, MN</p><p>Dr. Phillip A. Sharp, Massachusetts Institute of Technology, Cambridge, MA</p><p>Dr. Mark C. Williams, Northeastern University, Boston, MA</p></td><td><p>O6 Alkylguanine-DNA Alkyltransferase. New Functions For A Guardian of the Genome.</p><p>Bloomfield-Inspired Biophysics in HIV Research</p><p>From Biophysics to RNA Biology</p><p>Mechanochemistry of DNA binding: From small molecules to proteins</p></td></tr><tr><td><h4>2010</h4><p>Unconventional Nucleic Acid Biology<br>(<a href="/sites/cbs.umn.edu/files/public/downloads/2010-program.jpg">Poster</a>)</p></td><td><p>Dr. Brenda Bass, University of Utah, Salt Lake City, UT</p><p>Dr. Ronald Breaker, Yale University, New Haven, CT</p><p>Dr. Simon Wain-Hobson, Pasteur Institute, Paris, France</p><p>Dr. Michael Neuberger, University of Cambridge, Cambridge, UK</p></td><td><p>Toward a mechanistic understanding of Dicer's different roles in processing dsRNA.</p><p>Riboswitches- Molecular Relics from the RNA World?</p><p>&nbsp;</p><p>The pros and cons of viral hypermutation.</p><p>&nbsp;</p><p>Antibody diversification through DNA deamination.</p></td></tr><tr><td><h4>2009</h4><p>The Biochemistry of Biofuels<br>(<a href="/sites/cbs.umn.edu/files/public/downloads/2009-Poster.jpg">Poster</a>)</p><p>&nbsp;</p></td><td><p>Dr. Timothy Donohue, University of Wisconsin-Madison</p><p>Dr. Jay Keasling, University of California, Berkeley</p><p>Dr. James C. Liao, University of California, Los Angeles</p><p>Dr. Stephen Ragsdale, University of Michigan, Ann Arbor</p></td><td><p>Tapping into Microbial Genomes for Light-driven Hydrogen Production.</p><p>Engineering Microorganisms for Production of Advanced Biofuels.</p><p>Fuels and Chemical Beyond Petroleum.</p><p>Nickel Enzymes in the Biochemistry of Biofuels.</p><p>&nbsp;</p></td></tr><tr><td><h4>2008</h4><p>Circadian Clocks<br>(<a href="https://www.cbs.umn.edu/sites/cbs.umn.edu/files/public/downloads/2008-Po... target="_blank">Poster</a>)</p></td><td><p>Dr. Steve A. Kay, University of California, San Diego</p><p>Dr. Amita Sehgal, HHMI/ University of Pennsylvania Medical School</p><p>Dr. Joseph S. Takahashi, HHMI/Northwestern University</p><p>Dr. Ying-Hui Fu, University of California, San Francisco</p></td><td><p>Network Discovery Pipelines for Circadian Clocks.</p><p>Molecular Biology of Circadian Rhythms in Drosophila.</p><p>Genetic Analysis of Circadian Clocks in Mammals.</p><p>Molecular Characterization of Human Sleep Variants.</p></td></tr><tr><td><h4>2007</h4><p>Reguating Biological Function by Ubiquitination</p></td><td><p>Dr. Rachel Klevit, University of Washington, Seattle, WA</p><p><br>Dr. Keith D. Wilkinson, Emory University School of Medicine, Atlanta, GA<br><br>Dr. Daniel Finley, Harvard Medical School, Boston, MA<br><br>Dr. Randy Hampton, University of California, San Diego, La Jolla, CA</p></td><td><p>Recognition and Disassembly of the Polyubiquitin Targeting Signal.</p><p>Structural Insights into Diversity and specificity in Protein Ubiquitination.</p><p>Regulation of Protasome Activity.<br><br>Protein Quality Control in Cell Regulation.</p></td></tr><tr><td><h4>2006</h4><p>The Science of Aging</p></td><td><p>Dr. Leonard P. Guarante, MIT, Boston</p><p>Dr. Holly Van Remmen, University of Texas, San Antonio<br><br>Dr. Richard A. Miller, University of Michigan<br><br>Dr. Richard Weindruch, University of Wisconsin</p></td><td><p>SIR2, Calorie Restriction and Aging</p><p>Fifty Years of the Oxidative Stress Theory of Aging: Where Are We Now? Fifty Years of the Oxidative Stress Theory of Aging: Where Are We Now?</p><p>Size, Stress, and Aging: Lessons from Dwarf Mice</p><p>Caloric Restriction and Aging: Studies in Mice and Monkeys</p></td></tr><tr><td><h4>2005</h4><p>Computational Biochemistry and Molecular Biology</p></td><td><p>Dr. Eric D. Siggia, Rockefeller University in New York<br><br>Dr. Peter D. Karp, Stanford Research Institute International (SRI), Palo Alto (CA)<br><br>Dr. Michael A. Savageau, University California, Davis.<br><br>Dr. Jiali Gao, University of Minnesota</p></td><td><p>Computation Approaches to Blastoderm Patterning in the Fly and its Evolution.</p><p>Databases and Algorithms for Pathway Bioinformatics.</p><p>System Design Principles and Construction of Gene Circuits</p><p>Dynamics, Pathways, and Tunneling: A Computational Perspective of Enzyme Catalysis</p></td></tr><tr><td><h4>2004</h4><p>Proteomics: Advancing Our Understanding of Biology</p><p>&nbsp;</p></td><td><p>Michel Desjardins, Université de Montréal</p><p>Tim Haystead,Duke University Medical Center</p><p>Kathryn E. Howell<br>University of Colorado School of Medicine, Denver</p><p>Bradford W. Gibson<br>Buck Institute of Aging Research</p></td><td><p>Proteomics Brings New Paradigms to Immunology<br><br>Proteome Mining Drug and Target Discovery en Masse.</p><p>New Insights into Golgi Function Through Proteomics</p><p>The Mitochondrial Proteome, Neurodegenerative Disease and Aging</p></td></tr><tr><td><h4>2003</h4><p>Structural Dymamics of Membrane Signal Transduction</p><p>&nbsp;</p></td><td><p>Dr. Wayne Hubbell, Jules Stein Eye Institute, UCLA</p><p>Dr. Lynmarie Thompson, University of Massachusetts, Amherst</p><p>Dr. John Spudich, University of Texas, Houston</p><p>Dr. David Farrens, Oregon Health and Science University</p></td><td><p>A nitroxide's view of rhodopsin structure, dynamics and activation</p><p>Site-directed solid-state NMR probing transmembrane signaling mechanisms in bacterial chemoreceptors.</p><p>Microbial rhodopsins: structure/function in ion transport and signaling.</p><p>Conformational changes in G-protein coupled receptors: insights gained from site-directed fluorescence studies.</p></td></tr><tr><td><h4>2002</h4><p>Nature's Copier: the DNA Replication Machinery</p></td><td><p>Dr. Melvin DePamphilis, National Institute of Child Health and Human Development</p><p>Dr. Bik-Kwoon Tye, Cornell University</p><p><br>Dr. James Berger, University of California, Berkeley</p></td><td><p>The ORC Cycle: a Novel Mechanism for Regulating Eukaryotic DNA Replication</p><p>Coordination of Genome Expression and DNA Replication in Proliferating Cells: The Multiple Roles of the MCM Proteins in Eukaryotes</p><p>Toward a Structural Understanding of DNA Replication Initiation</p></td></tr><tr><td><h4>2001</h4><p>Directed Evolution of Biomolecules &amp; Functional Genomics</p></td><td><p>Dr. Jeremy Minshull, Maxygen</p><p>Dr. Karl Dane Wittrup, Massachusetts Institute of Technology</p><p>Dr. George Georgiou, University of Texas</p><p>&nbsp;</p></td><td><p>Biological Diversity: From Nature and Beyond.</p><p>Engineering Protein Recognition, Stability, and Expression by Yeast Display</p><p>Functional Expression of Multidisulfide Proteins in<br>Bacteria: Genetic, Biochemical, Structural Biology and Directed Evolution Strategies.</p></td></tr><tr><td><h4>2000</h4><p>G Protein-Coupled Signaling</p></td><td><p>Nigel Bunnett, University of California, San Francisco</p><p>Linda Hicke, Northwestern University</p><p>John Tesmer, University of Texas</p><p><br>David Clapham, Harvard Medical School</p></td><td><p>How Proteases Talk to Cells: &nbsp; A Comparison of Signaling by Proteases and Neuropeptides</p><p>Role of Ubiquitin in Signaling Receptor Downregulation</p><p>Effector Regulation by Heterotrimeric G &nbsp; Proteins: &nbsp; Lessons Learned from Adenyl Cyclase</p><p>Protein Gated Potassium Channels</p></td></tr><tr><td><h4>1999</h4><p>Transcription Factors &amp; Metabolic Control</p></td><td><p>Gretchen J. Darlington, Baylor College of Medicine<br><br>Steven A. Kliewer, Glaxo-Wellcome Research &amp; Development</p><p>Timothy S. Osborne, University of California, Irvine</p></td><td><p>The Role of C/EBP Proteins in Integratie Metabolism</p><p>PPARs and PXR: Orphan Nuclear Receptors that Define Novel Hormone Signaling Pathways.</p><p>Positive and Negative Regulation of Genes that Regulate Cholesterol Metabolism.</p></td></tr></tbody></table><p>&nbsp;</p>