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Stanley Dagley Lectureship Series

2017 Dagley Lecture

"Feedback loops in directed evolution"

Dr. Andrew D. Ellington

Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX

Wednesday, October 25, 2017
4:00 - 5:00 pm
2-137 Jackson Hall, Minneapolis Campus


Background

Stanley Dagley Regents Professor of Biochemistry BMBB faculty 1970-1987Stanley Dagley was Regents Professor of Biochemistry at the University of Minnesota. Known for his luminary teaching, Professor Dagley was also highly regarded for his research on microbial oxidation reactions. Dagley first studied microbial biochemistry from a thermodynamics standpoint with Chemistry Nobel Laureate Sir Cyril Hinshelwood at Oxford. He started his professorial career at the University of Leeds prior to his distinguished tenure at the University of Minnesota.

Professor Stanley Dagley inspired a legion of scientists to investigate novel and exotic microbial biochemistry using simple, but elegant, biochemical logic. Some of those he inspired have initiated the Stanley Dagley Lectureship.

Stanley Dagley, Regents Professor of Biochemistry, BMBB faculty 1970-1987


 

Archive

Year

Speaker/Affiliation

Title

2016

Dr. Christina Smolke

Professor of Bioengineering, Schools of Engineering & Medicine,

Stanford University, Stanford CA

Synthetic biology platforms for naturl product biosynthesis and discovery

2015

Dr. Donald Hilvert

Professor of Chemistry, Swiss Federal Instuitute of Technology Z├╝rich (ETH), Swizerland

Nearer to nature: design and optimization of artificial enzymes

Self-assembling, subercharged protein containers

2014

Dr. Pamela Silver
Elliot T. and Onie H. Adams Professor of Biochemistry and Systems Biology, Harvard Medical School, Boston, MA

Biology is the technology of this century

Designing biological systems for health and sustainability

2013

Dr. Dan S. Tawfik
Professor, Department of Biological Chemistry, The Weizmann Institute of Sciences, Rehovolt, Israel

Promiscuity, noise and the divergence of new protein functions

The ongoing expansion of protein sequence space

2012

Dr. Frances H. Arnold

Dick and Barbara Dickinson Professor of Chemical Engineering, Bioengineering & Biochemistry, California Institute of Technology

 

Design by evolution: engineering biology in the 21st century

Enzyme engineering by structure-guided recombination

2011

Dr. Jack Szostak (Nobel Laureate)
Center for Computational and Integrative Biology, Harvard Medical School, Boston, MA

The Origin of Cellular Life

Towards Self-Replicating Genetic Polymers

2010

Dr. John Roth
University of California, Davis, CA

A molecular view of natural selection: Understanding high-speed adaptation.

Pathways of genetic change: Three stories about gene copy number changes.

2008

Dr. Stephen Withers
University of British Columbia, Vancouver, BC, Canada

Sugars are good for you: their roles as therapeutics.

Engineering and evolution of old enzymes for new tasks: glycoside assembly.

2007

Dr. Gregory A. Petsko
Brandeis University; Waltham, MA
(Adjunct Professor, Harvard Medical School)

Structural Enzymology in Four Dimensions: Time-Resolved Crystal Structures of Enzymes At Work.

The Next Epidemic: What Happens To Your Brain As You Get Older and What We're Trying To Do About It.

2006

Dr. Peter G. Schultz
The Scripps research Institute, La Jolla, CA

An expanding genetic code.

Synthesis at the interface of chemistry and biology.

2005

Dr. Perry Frey
University of Wisconsin, Madison

A story of hydrogen bonding: The low-barrier hydrogen bond in chymotrypsin.

Science and Antiscience.

2004

Sir David Hopwood
John Innes Centre, Norwich, UK

The discovery and development of antibiotics.

Using Streptomyces genes to make new antibiotics.

2003

Dr. Rolf Thauer
Max Plank Institute, Germany

On Methanogens and Methanotrophs.

Biochemistry of Methanogenesis.

2002

Dr. Arthur Kornberg (Nobel Laureate)
Stanford University School of Medicine

Reflections on DNA Replication and Current Studies on Inorganic Polyphosphate.

Biotechnology: Academia and/or Business.

2001

Dr. Daniel Koshland, Jr.
University of California, Berkeley

Propogation of Conformational Changes in Receptors and Enzymes.

Scientific Advances: What Will We be Able To Do and What Will We Be Allowed To Do?