2017 Dagley Lecture
"Feedback loops in directed evolution"
Dr. Andrew D. Ellington
Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX
Wednesday, October 25, 2017
4:00 - 5:00 pm
2-137 Jackson Hall, Minneapolis Campus
Stanley Dagley was Regents Professor of Biochemistry at the University of Minnesota. Known for his luminary teaching, Professor Dagley was also highly regarded for his research on microbial oxidation reactions. Dagley first studied microbial biochemistry from a thermodynamics standpoint with Chemistry Nobel Laureate Sir Cyril Hinshelwood at Oxford. He started his professorial career at the University of Leeds prior to his distinguished tenure at the University of Minnesota.
Professor Stanley Dagley inspired a legion of scientists to investigate novel and exotic microbial biochemistry using simple, but elegant, biochemical logic. Some of those he inspired have initiated the Stanley Dagley Lectureship.
Stanley Dagley, Regents Professor of Biochemistry, BMBB faculty 1970-1987
Dr. Christina Smolke
Professor of Bioengineering, Schools of Engineering & Medicine,
Stanford University, Stanford CA
Synthetic biology platforms for naturl product biosynthesis and discovery
Dr. Donald Hilvert
Professor of Chemistry, Swiss Federal Instuitute of Technology Zürich (ETH), Swizerland
Nearer to nature: design and optimization of artificial enzymes
Self-assembling, subercharged protein containers
Dr. Pamela Silver
Biology is the technology of this century
Designing biological systems for health and sustainability
Dr. Dan S. Tawfik
Promiscuity, noise and the divergence of new protein functions
The ongoing expansion of protein sequence space
Dr. Frances H. Arnold
Dick and Barbara Dickinson Professor of Chemical Engineering, Bioengineering & Biochemistry, California Institute of Technology
Design by evolution: engineering biology in the 21st century
Enzyme engineering by structure-guided recombination
Dr. Jack Szostak (Nobel Laureate)
The Origin of Cellular Life
Towards Self-Replicating Genetic Polymers
Dr. John Roth
A molecular view of natural selection: Understanding high-speed adaptation.
Pathways of genetic change: Three stories about gene copy number changes.
Dr. Stephen Withers
Sugars are good for you: their roles as therapeutics.
Engineering and evolution of old enzymes for new tasks: glycoside assembly.
Dr. Gregory A. Petsko
Structural Enzymology in Four Dimensions: Time-Resolved Crystal Structures of Enzymes At Work.
The Next Epidemic: What Happens To Your Brain As You Get Older and What We're Trying To Do About It.
Dr. Peter G. Schultz
An expanding genetic code.
Synthesis at the interface of chemistry and biology.
Dr. Perry Frey
A story of hydrogen bonding: The low-barrier hydrogen bond in chymotrypsin.
Science and Antiscience.
Sir David Hopwood
The discovery and development of antibiotics.
Using Streptomyces genes to make new antibiotics.
Dr. Rolf Thauer
On Methanogens and Methanotrophs.
Biochemistry of Methanogenesis.
Dr. Arthur Kornberg (Nobel Laureate)
Reflections on DNA Replication and Current Studies on Inorganic Polyphosphate.
Biotechnology: Academia and/or Business.
Dr. Daniel Koshland, Jr.
Propogation of Conformational Changes in Receptors and Enzymes.
Scientific Advances: What Will We be Able To Do and What Will We Be Allowed To Do?