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Our faculty and students are creating new knowledge every day and driving solutions to some of our greatest challenges. You are now viewing a collection of discoveries at the College of Biological Sciences.

Virus' DNA-Hijacking Ability Explained

Surprising results solve a decades-old puzzle and open door to exploring new therapies to combat HIV-1, retrovirus-based cancers.
Hideki Aihara, Ke Shi and Zhiqi Yin
Hideki Aihara, Ke Shi and Zhiqi Yin 

Retroviruses are cagy buggers.

A Long-Standing Cellular Puzzle, Solved

New faculty member Charalampos Babis Kalodimos discovers why the drug cyclosporine improves outcomes for cancer patients.
Charalampos Babis Kalodimos

Kalodimos in the University's Structural Biology Nuclear Magnetic Resonance Facility.

Enzyme Linked to Therapy's Effectiveness

Harris lab finds resistance to tamoxifen breast cancer therapy may be driven by APOBEC3B.

Responses to tamoxifen were significantly prolonged by reducing levels of the enzyme APOBEC3B in preclinical models of estrogen receptor–positive breast cancer and significantly shortened by increasing levels of APOBEC3B, suggesting that APOBEC3B drives resistance to tamoxifen, according to data presented at the 2015 San Antonio Breast Cancer Symposium, held Dec.

Hibernation and Heart Health

Tim Griffin and colleagues use multiomics to study how ground squirrels’ hearts adapt to hibernation.

Ground squirrel

“We had a lot of genomic data — transcribed RNA within these hibernating animals — pointing to genes that are turned off and on during hibernation."

Tim Griffin, director of the Center for P

Steroid Surprise

Mutant mystery leads to discovery of new mechanism for hormone transport.

"We don’t know what it is yet that’s controlling the movement of these vesicles. ...

Research Round-Up: Summer 2015

The latest publications from College of Biological Sciences researchers.
Researchers find metabolic enzyme may have broader reach

A study led by Michael O’Connor and post-doctoral fellow Arpan Ghosh (Genetics, Cell Biology and Development) found that a metabolic enzyme thought to be active only in microbes and not in higher eukaryotes may be active in higher eu