Protein relative abundance patterns associated with sucrose-induced dysbiosis are conserved across taxonomically diverse oral microcosm biofilm models of dental caries.
Rudney et al., BMC Microbiome DOI: 10.1186/s40168-015-0136-z
- Extensive inter-individual variation in dental plaque composition
- Sucrose induces acid production in dental caries (dysbiosis)
Inter-individual variation in taxonomy persists in dysbiotic state
- Are function-based protein abundance patterns more conserved?
- Plaque microcosms grown from carious lesions in 12 children
- Paired design – microcosms grown in presence/absence of sucrose
- Taxonomic composition established by 16S rRNA sequencing
- 2-D LC-MS/MS Metaproteome analyzed for taxonomy and function
- Sucrose microcosms retained inter-individual taxonomic variation
- Protein relative abundance patterns were more highly conserved
- Function-based changes may be better indicators of dysbiosis