I have worked on a variety of projects which take advantage of my molecular genetic knowledge and expertise. Most of my work recently has been in the Developmental Timing project. I have been attempting, using numerous approaches, to obtain a PTTH mutant. This remains an ongoing project. Second, I am characterizing the PTTH regulatory region with the ultimate goal of obtaining the positive regulatory sequence of PTTH.
In addition to my research projects, I am the lab manager. I do the ordering, mail stock requests, maintain the fly database and the lab web page, and whatever else is needed to keep Mike's lab running smoothly.
Peterson, A.J., Jensen, P.A., Shimell, M.J., Stefancsik, R., Wijayatonge, R., Herder, R. Raftery, L.A. and O'Connor M. B., R-Smad competition controls Activin receptor output in Drosophila. Plos One 7(5): e36548. doi:10.1371/journal.pone.0036548
Ono H, Rewitz KF, Shinoda T, Itoyama K, Petryk A, Rybczynski R, Jarcho M, Warren JT, Marques G, Shimell MJ, Gilbert LI, O'Connor MB. 2006 Oct Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera. Dev Biol 15;298(2):555-70. Epub
McBrayer, Z.*, Ono, H.*, Shimell, MJ*, Parvy, J.-P., Beckstead, R.B., Warren, J.T., Thummel, C.S., Dauphin-Villemant, C., Gilbert, L.I., and O’Connor, M.B. (2007) Prothoracicotropic hormone regulates developmental timing and body size in Drosophila.Dev. Cell 13: 857-871
Warren JT, Yerushalmi Y, Shimell MJ, O'Connor MB, Restifo LL, Gilbert LI (2006). Discrete pulses of molting hormone, 20-hydroxyecdysone, during late larval development of Drosophila melanogaster: correlations with changes in gene activity. Dev. Dyn. 235, 315-26.
Marques G, Bao H, Haerry TE, Shimell MJ, Duchek P, Zhang B, O'Connor MB (2002). TheDrosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function. Neuron 33, 529-43.
Shimell MJ, Peterson AJ, Burr J, Simon JA,O'Connor MB (2000). Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene. Dev. Biol. 218, 38-52.
Brummel T, Abdollah S, Haerry TE, Shimell MJ,Merriam J, Raftery L, Wrana JL, O'Connor MB(1999). The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev. 13, 98-111.
Marques G, Musacchio M, Shimell MJ, Wunnenberg-Stapleton K, Cho KW, O'Connor MB(1997). Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins. Cell 91, 417-26.
Nguyen T, Jamal J, Shimell MJ, Arora K, O'Connor MB (1995). Characterization of tolloid-related-1: a BMP-1-like product that is required during larval and pupal stages of Drosophila development. Dev. Biol. 166, 569-86.
Shimell MJ, Simon J, Bender W, O'Connor MB (1994). Enhancer point mutation results in a homeotic transformation in Drosophila. Science 264, 968-71.
Shimell MJ, Ferguson EL, Childs SR, O'Connor MB (1991). The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein Cell 67, 469-81.