From 1974 until 2007, R. K. Herman's laboratory worked on the developmental and behavioral genetics of the free-living nematode Caenorhabditis elegans. Much of the laboratory's work was directed at developing genetic techniques, involving, for example, chromosome mechanics, mutagenesis, analysis of genetic mosaics, and approaches to genetic redundancy. The laboratory also applied these and other techniques to the study of a variety of topics in C. elegans development and behavior. R. K. Herman retired in 2007 but continues to follow current work in the field.
Selected Publications (Pubmed Search)
Bell L. R., Stone, S., Yochem, J., Shaw, J. E., and Herman, R. K. (2006) The molecular identities of the Caenorhabditis elegans intraflagellar transport genes dyf-6. daf-10 and osm-1. Genetics 173: 1275-86.
Herman, R. K., and Yochem, J. (2005) Genetic enhancers. WormBook Sep 16: 1-11. http://wormbook.org
Yochem, J., and Herman, R. K. (2005) Genetic mosaics. WormBook Dec. 27: 1-6. http://wormbook.org
Yochem, J, Bell, L. R., and Herman, R. K. (2004) The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans. Genetics 168: 1293-306.
Spartz, A. K., Herman, R. K., and Shaw, J. E. (2004) SMU-2 and SMU-1, Caenorhabditis elegans homologs of mammalian spliceosome-associated proteins RED and fSAP57, work together to affect splice site choice. Mol. Cell. Biol. 24: 6811-23.