Research statement
My laboratory research is focused in the areas of cancer stem cells and cancer metabolism. Our current objectives are focused on defining how steroid receptors (e.g., estrogen receptor [ER], progesterone receptor [PR]) and their associated co-activators mediate the survival and expansion of breast CSCs with emphasis on altered oncogenic signaling pathways and metabolic reprogramming.
Selected publications
- Truong, T.H., Benner, B., Hagen, K.M., Temiz, N.A., Perez Kerkvliet, C., Wang, Y., Cortes-Sanchez, E., Yang, C.-H., Trousdell, M.C., Pengo, T., Guillen, K.P., Welm, B.E., Dos Santos, C.O., Telang, S., Lange, C.A., and Ostrander, J.H. (2021). “PELP1/SRC-3 dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer.” Oncogene. 40(25): 4384-4397.
- Dwyer, A.R., Truong T.H., Perez Kerkvliet, C., Paul, K.V., Kabos, P., Sartorius, C.A., and Lange, C.A. (2021). “Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in ER+ breast cancer.” Brit. J. Cancer. 124 (1), 217-227.
- Truong, T.H.*, Dwyer, A.R.*, Diep, C., Hu, H., Hagen, K.M., and Lange, C.A. (2019). “Phosphorylated progesterone receptor isoforms mediate opposing stem-like and proliferative breast cancer cell fates.” Endocrinology. 160(2), 430-446. *Equal contribution
- Truong, T.H., Hu, H., Temiz, N.A., Hagen, K.M., Girard, B.J., Brady, N.J., Schwertfeger, K.L., Lange, C.A., and Ostrander, J.H. (2018). “Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models Are Promoted by PELP1/AIB1 Complexes.” Mol. Cancer Res. 16 (4) 707-719.
- Truong, T.H., and Lange, C.A. (2018). “Tracking Steroid Receptor Crosstalk in Hormone-Driven Cancers.” Endocrinology, 159(12), 3897-3907.
- Truong, T.H., Ung, P.M., Palde, P.B., Paulsen, C.E., Schlessinger, A., and Carroll, K.S. (2016). “Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase.” Cell Chem. Biol. 23 (7), 837-848.
- Truong, T.H. and Carroll, K.S. (2012). “Redox Regulation of Epidermal Growth Factor Receptor Signaling through Cysteine Oxidation.” Biochemistry. 51 (50), 9954-9965.
- Paulsen, C.E., Truong, T.H., Garcia, F.J., Homann, A., Gupta V., Leonard, S.E., Carroll, K.S. (2011). “Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity.” Nat. Chem. Biol. 8 (1), 57-64.
Education
- Postdoctoral Fellow - University of Minnesota Masonic Cancer Center
- Ph.D. in Chemistry (Chemical Biology) - University of Michigan, 2014
- B.S. in Chemistry - Texas A&M University, 2008