College of Biological Sciences

College of Pharmacy

Research Interests

Dr. Oetting's research focuses on the genetic analysis of common diseases. His major research is identifying genetic variants associated with adverse outcomes in solid organ transplantation focusing on the pharmacogenomics of immunosuppressants. This work is includes using genome wide association studies (GWAS).

Dr. Oetting is also interested in determining variants associated with the pigmentation disorder albinism.  Current work includes the identification of non-coding variants associated with loss of function.

Mohamed ME, Schladt DP, Guan W, Wu B, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Oetting WS, Jacobson PA; (2019) DeKAF Genomics and GEN03 Investigators. Tacrolimus troughs and genetic determinants of metabolism in kidney transplant recipients: A comparison of four ancestry groups. American Journal of Transplantation (in press), 2019. [PMID: 30801552]

Stapleton CP, Heinzel A, Guan W, van der Most PJ, van Setten J, Lord GM, Keating BJ, Israni AK, de Borst MH, Bakker SJL, Snieder H, Weale ME, Delaney F, Hernandez-Fuentes MP, Reindl-Schwaighofer R, Oberbauer R, Jacobson PA, Mark PB, Chapman FA, Phelan PJ, Kennedy C, Sexton D, Murray S, Jardine A, Traynor JP, McKnight AJ, Maxwell AP, Smyth LJ, Oetting WS, Matas AJ, Mannon RB, Schladt DP, Iklé DN, Cavalleri GL, Conlon PJ; UK Ireland Renal Transplant Consortium; DeKAF Genomics and GEN03 Studies; International Genetics and Translational Research in Transplantation Network. (2019) The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population. American Journal of Transplantation 2019 Aug;19(8):2262-2273 [PMID: 30920136]

Oetting WS, Wu B, Schladt DP, Guan W, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN-03 Investigators. (2019) Genetic Variants associated with immunosuppressant pharmacokinetics and adverse effects in the DeKAF Genomics genome wide association studies. Transplantation 2019 Jun;103(6):1131-1139. [PMID: 30801552]

Oetting WS, Schladt DP, Dorr CR, Wu B, Guan W, Remmel RP, Iklé D, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN03 Investigators. (2019) Analysis of 75 candidate SNPs associated with acute rejection in kidney transplant recipients: Validation of rs2910164 in microRNA MIR146A. Transplantation 2019 Aug;103(8):1591-1602. [PMID: 30801535]

Dorr CR, Wu B, Remmel RP, Muthusamy A, Schladt DP, Abrahante JE, Guan W, Mannon RB, Matas AJ, Oetting WS, Jacobson PA, Israni AK; for DeKAF Genomics. (2019) Identification of genetic variants associated with tacrolimus metabolism in kidney transplant recipients by extreme phenotype sampling and next generation sequencing. Pharmacogenomics Journal 2019 Aug;19(4):375-389. [PMID: 30442921] [PMCID: PMC6522337]

Wu JF, Muthusamy A, Al-Ghalith GA, Knights D, Guo B, Wu B, Remmel RP, Schladt DP, Alegre M-L, Oetting WS, Jacobson PA Israni AK. (2018) Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients. Clinical Transplantation 2018 Dec;32(12):e13436. [PMID: 30372560]

Seibert SR, Schladt DP, Wu B, Guan W, Dorr C, Remmel RP, Matas AJ, Mannon RB, Israni AK, Oetting WS, Jacobson PA. (2018) Tacrolimus trough and dose intra-patient variability and CYP3A5 genotype: Effects on acute rejection and graft failure in European American and African American kidney transplant recipients. Clinical Transplantation 2018 Dec;32(12):e13424. . [PMID: 30318646]

Scheibner A, Remmel R, Schladt D, Oetting WS, Guan W, Wu B, Dorr C, Israni A, Jacobson PA. (2018) Tacrolimus elimination in four subjects with a CYP3A5*3/*3 CYP3A4*22/*22 genotype. Pharmacotherapy, 38:e46-e52, 2018. [PMID: 29804290]

Snoek R, van Setten J, Keating BJ, Israni AK, Jacobson PA, Oetting WS, Matas AJ, Mannon RB, Zhang Z, Zhang W, Hao K, Murphy B, Reindl-Schwaighofer R, Heinzl A, Oberbauer R, Viklicky O, Conlon PJ, Stapleton CP, Bakker SJL, Snieder H, Peters EDJ, van der Zwaag B, Knoers NVAM, de Borst MH, van Eerde AM. (2018) NPHP1 (Nephrocystin-1) gene deletions cause adult-onset ESRD. Journal of the American Society of Nephrology, 2018 Jun;29(6):1772-1779. [PMID: 29654215] [PMCID: PMC6054334]

Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Dorr C, Mannon RB, Matas AJ, Israni AK, Jacobson PA for the DeKAF Investigators. (2018) Attempted Validation of 44 Reported SNPs Associated with Tacrolimus Troughs in a Cohort of Kidney Allograft Recipients. Pharmacogenomics 2018 Feb;19(3):175-184. [PMID: 29318894] [PMCID: PMC6021962]

Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Mannon RB, Matas AJ, Israni AK, Jacobson PA for the DeKAF Investigators. (2018) Genome wide association study identifies the common variants in CYP3A4 and CYP3A5 responsible for variation in tacrolimus trough concentration in Caucasian kidney transplant recipients. Pharmacogenomics Journal 2018 May 22;18(3):501-505. [PMID: 29160300]

Oetting WS, Dorr C, Remmel RP, Matas AJ, Israni AK, Jacobson PA. (2017) Concepts of genomics in kidney transplantation. Current Transplantation Reports 2017 Jun;4(2):116-123. [PMID: 29123971] [PMCID: PMC5673265]

Dorr CR, Remmel RP, Muthusamy A, Fisher J, Moriarity BS, Yasuda K, Wu B, Guan W, Schuetz EG, Oetting WS, Jacobson PA, Israni AK. (2017) CRISPR/Cas9 genetic modification of CYP3A5 *3 in human hepatocytes leads to cell lines with increased midazolam and tacrolimus metabolism. Drug Metabolism and Disposition 2017 Aug;45(8):957-965. [PMID: 28533324] [PMCID: PMC5518718]

Oetting WS, Schladt DP, Guan W, Miller MB, Remmel RP, Dorr C, Sanghavi K, Mannon RB, Herrera B, Matas AJ, Salomon DR, Kwok PY, Keating BJ, Israni AK, Jacobson PA for the DeKAF Investigators. (2016) Genome wide association study of tacrolimus concentrations in African American kidney transplant recipients identifies multiple CYP3A5 alleles. American Journal of Transplantation 16:574-582, 2016. [PMID: 26485092] [PMCID: PMC4733408]