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University of Minnesota RNA Supergroup

On the biological and biomedical importance of RNA:

The biomolecule RNA (Ribonucleic Acid) plays diverse roles in biology, including these prime examples:

  • RNA has central roles in the transmission and decoding of genetic information.
  • RNA serves as a genome for viruses that have huge economic and health impacts. 
  • RNA catalyzes crucial biochemical reactions. 
  • RNA provides a structural framework for macromolecular machines. 
  • RNA molecules act in cis or in trans to control gene expression and biochemical processes.
  • Dysfunction and dysregulation of RNA underlie diseases including cancer, immune disorders, neurodegeneration, diabetes, and viral diseases.
RNA research at the University of Minnesota:

We are a community of RNA researchers who employ a wide range of techniques to study RNA function and disorders using approaches spanning from the atomic to organismal levels. RNA research is at highpoint of discovery with enormous impact on our understanding of biology and disease. These advances are being fueled by rapid advances in genomics and next generation sequencing, bioinformatics, genome editing, and imaging technologies.

The mission of the RNA Supergroup:
  • To advance RNA research to the benefit of the public and medicine
  • To connect RNA researchers and promote multidisciplinary collaborations
  • To enhance the training of students and postdoctoral fellows
  • To communicate the importance of RNA biology and its medical relevance to the community
  • To elevate the University of Minnesota’s reputation in RNA research
  • To facilitate recruitment of RNA researchers
  • To promote development of collaborative research grants
  • To facilitate expansion of shared research resources
This mission is promoted through the following activities:
  • RNA Bioscience Research in Progress seminars
  • RNA World journal club
  • UMN faculty research seminars
  • Invited seminars from leading RNA researchers

Participating RNA Supergroup faculty:

Frank Albert studies how regulatory genetic variation among individuals shapes transcriptomes and proteomes.

 

 

 

Kate Amadala focuses on developing and applying tools for readout of mammalian cell states and for control of cellular processes, achieved via combining top-down and bottom-up, RNA-based approaches to synthetic biology.

 

 

 

Paul Bohjanen studies the role of mRNA decay in regulating T lymphocyte gene expression and seeks to understand the biochemical mechanisms that regulate mRNA decay during T lymphocyte activation and disease states such as malignancy or virus infection.

 

 

 

Peter Bitterman investigates how the protein synthesis apparatus regulates gene expression and cell function. His laboratory focuses on the pathological activation of translation initiation complex eIF4F, which imparts primary fibroblasts and epithelial cells with autonomy for growth and survival and is required for cancer cells to maintain a malignant phenotype.

 

 

 

Kathleen Boris-Lowrie studies post-transcriptional control of retroviruses, from HIV-1 to Rous sarcoma virus. Her primary interest is translation control by structural elements in the 5' untranslated region of viral and select cellular mRNAs and transactivation by RNA binding proteins. 

 

 

 

Scott Dehm studies transcriptional regulation of RNA expression mediated by the androgen receptor.  His laboratory also studies mRNA splice variants of the androgen receptor, which are constitutively active transcription factors that drive resistance to therapies for prostate cancer. 

 

 

 

Aaron Engelhart pursues research towards a better understanding of nucleic acid folding and function in order to 1) elucidate unanticipated roles for nucleic acids in vivo and 2) develop novel nucleic acid-based catalysis, imaging, analytical, and diagnostic technologies

 

 

 

Aaron Goldstrohm studies post-transcriptional regulation of messenger RNAs by RNA-binding proteins, ribonucleases, and non-coding RNAs with biomedical relevance to cancer, obesity, and neurological disorders.

 

 

 

Guisheng Song researches the regulatory roles of microRNAs in non-alcoholic fatty liver disease and liver cancer.

 

 

 

David Greenstein works on germline development in the nematode Caenorhabditis elegans. One main project in the lab investigates the mechanisms by which the TRIM-NHL protein LIN-41 regulates female meiosis and the oogenenic program in this organism.

 

 

 

Ann Rougvie studies temporal regulation of gene expression during development using Caenorhabditis elegans.

 

 

 

Irina St. Louis researches the molecular mechanisms that control human gene expression through regulated mRNA degradation, especially RNA-binding proteins and intracellular signaling pathways that affect the stability and translational efficiency of mRNAs encoding proto-oncogenes, cytokines, and cell cycle regulators.

 

 

Subbaya Subramanian studies microRNA regulatory networks in sarcoma and other cancers.

 

 

 

 

Jeongsik Yong researches post-transcriptional regulation of mRNA processing in cancer.

 

 

 


Join us:

Anyone with an interest in RNA can join the RNA Supergroup by emailing Aaron Goldstrohm


Upcoming RNA Supergroup Events:

RNA World Journal Club, beginning Friday Sept 22nd

            Contact Aaron Goldstrohm for more information at agoldstr@umn.edu

 

Oct 2, 2017  26th Annual Developmental Biology Symposium,

RNA rules: developmental regulation by RNA, Coffman Memorial Union

 

Maria Barna, Stanford University

“Novel Modes of Cellular Communication: From Specialized Ribosomes to Signaling Filopodia”

 

Douglas Black, University of California, Los Angeles

“Mechanisms and Programs of Posttranscriptional Gene Regulation in Neurons”

 

Anne Ephrussi, European Molecular Biology Laboratory

“Assembly and Transport of Oskar RNPs in the Drosophila Oocyte”

 

Antonio Giraldez, Yale University

“Uncovering Novel Regulatory Codes in Development”

 

Eric Miska, Gurdon Institute, University of Cambridge

“RNA and Epigenetics: New Insights from C. elegans and Rift Lake Cichlids”

 

Craig Pikaard, Indiana University

“Mechanisms of Selective Gene Silencing in Plants”

 

Howard Lipshitz, University of Toronto

“Post-Transcriptional Regulation of Gene Expression in Drosophila”

 

Oct 29, 2017 BMBB Seminar

            Dr. Anita Corbett, Emory University

 

March 14, 2018 BMBB Seminar

            Dr. Perry Blackshear, National Institutes Environmental Health Sciences

 

May 3, 2017   19th Bollum Symposium  Versatile Functions of RNA in Biology and Disease

1:00pm     Welcome

                   Dr. David BernlohrUniversity of Minnesota-Twin Cites

1:05pm     Introduction

                   Dr. Aaron GoldstrohmUniversity of Minnesota-Twin Cities

1:15pm     Dr. Hashim Al-HashimiDuke University

                   Dynamic RNA Structures in Translational Fidelity and Drug History

2:00pm     Dr. Lynne MaquatUniversity of Rochester

Nonsense-mediated mRNA Decay and Human Disease: Genome Guardian and Executor

2:45pm     Intermission

3:15pm     Dr. Kristen LynchUniversity of Pennsylvania

                   Getting Sick of Splicing: Alternative Splicing and the Humane Immune System

4:00pm     Dr. Maurice SwansonUniversity of Flordia

                   RNA-mediated Mechanisms in Development and Disease

4:45pm     Closing Remarks

                   Dr. Aaron GoldstrohmUniversity of Minnesota-Twin Cities

 

April 20th, 2017, RNA Supergroup Research in Progress Seminar

Dr. Subbaya Subramanian, Associate Professor, Department of Surgery

Title: Mechanisms of malignant transformation and immune regulation in colon cancer.

Learn more about his research here: https://subreelab.umn.edu/

 

April 5th, 2017, BMBB Seminar

Dr. Yunsun Nam Assistant Professor, Department of Obstetrics & Gynecology, Biophysics UT Southwestern Medical Center, Dalas, TX

 

March 8th, 2017, BMBB Seminar

Jens Lykke-Andersen, Ph.D., Professor of Biological Sciences from the University of California, San Diego. 

"Mechanisms of human mRNA turnover and quality control"

 

Dec 13th 2016, 4-5pm, Faculty Lightning Talks

            Dr. Aaron Goldstrohm

Associate Professor of Biochemistry, Molecular Biology and Biophysics

"Regulation of mRNA translation and decay in the eukaryotes"

 

Dr. Guisheng Song

"microRNA signaling in the pathogenesis of metabolic disorders and liver cancer"

Assistant Professor of Medicine, Division of Gastroenterology Hepatology and Nutrition

 

Dr. David Greenstein

"The Caenorhabditis elegans gonad: A test tube for RNA biology."

 

Nov 15th 2016, 4-5pm, Faculty Lightning Talks

            Dr. Scott Dehm

AR splice variants in prostate cancer

Associate Professor, Department of Laboratory Medicine and Pathology

 

Dr. Kate Adamala

Assistant Professor, Genetics, Cell Biology and Development 

 

Dr. Frank Alberts

Genomic approaches for dissecting regulatory genetic variation.

Assistant Professor, Genetics, Cell Biology and Development 

 

Sept 15th 2016, 4-5pm, Faculty Lightning Talks

Dr. Jeongsik Yong, Assistant Professor of Biochemistry, Molecular Biology and Biophysics

 

Kathleen Boris-Lawrie, Professor and Chair of Veterinary and Biomedical Sciences

 

Irina St. Louis, Assistant Professor of Medicine, Division of Infectious Diseases and International Medicine

 

Aaron Engelhart, Assistant Professor of Geneetics, Cell Biology and Development


RNA Research Resources:

Biomedical Genomics Center http://www.health.umn.edu/research/resources-researchers/genomics-center

Genome Editing Shared Resource http://www.cancer.umn.edu/for-researchers/shared-resources/genome-engineering

Minnesota Supercomputing Institute https://www.msi.umn.edu/tutorials/rna-seq-analysis

UMN Imaging Centers http://uic.umn.edu/

Center for Mass Spectrometry and Proteomics http://cbs.umn.edu/cmsp/home