Frank Albert studies how regulatory genetic variation among individuals shapes transcriptomes and proteomes.
Kate Adamala focuses on developing and applying tools for readout of mammalian cell states and for control of cellular processes, achieved via combining top-down and bottom-up, RNA-based approaches to synthetic biology.
Paul Bohjanen studies the role of mRNA decay in regulating T lymphocyte gene expression and seeks to understand the biochemical mechanisms that regulate mRNA decay during T lymphocyte activation and disease states such as malignancy or virus infection.
Peter Bitterman investigates how the protein synthesis apparatus regulates gene expression and cell function. His laboratory focuses on the pathological activation of translation initiation complex eIF4F, which imparts primary fibroblasts and epithelial cells with autonomy for growth and survival and is required for cancer cells to maintain a malignant phenotype.
Kathleen Boris-Lawrie studies post-transcriptional control of retroviruses, from HIV-1 to Rous sarcoma virus. Her primary interest is translation control by structural elements in the 5' untranslated region of viral and select cellular mRNAs and transactivation by RNA binding proteins.
Scott Dehm studies transcriptional regulation of RNA expression mediated by the androgen receptor. His laboratory also studies mRNA splice variants of the androgen receptor, which are constitutively active transcription factors that drive resistance to therapies for prostate cancer.
Aaron Engelhart pursues research towards a better understanding of nucleic acid folding and function in order to 1) elucidate unanticipated roles for nucleic acids in vivo and 2) develop novel nucleic acid-based catalysis, imaging, analytical, and diagnostic technologies
Aaron Goldstrohm studies post-transcriptional regulation of messenger RNAs by RNA-binding proteins, ribonucleases, and non-coding RNAs with biomedical relevance to cancer, obesity, and neurological disorders.
David Greenstein works on germline development in the nematode Caenorhabditis elegans. One main project in the lab investigates the mechanisms by which the TRIM-NHL protein LIN-41 regulates female meiosis and the oogenenic program in this organism.
Chad Myers uses computational and functional genomics approaches to study protein function and genetic networks.
Ann Rougvie studies temporal regulation of gene expression during development using Caenorhabditis elegans.
Guisheng Song researches the regulatory roles of microRNAs in non-alcoholic fatty liver disease and liver cancer.
Irina St. Louis researches the molecular mechanisms that control human gene expression through regulated mRNA degradation, especially RNA-binding proteins and intracellular signaling pathways that affect the stability and translational efficiency of mRNAs encoding proto-oncogenes, cytokines, and cell cycle regulators.
Subbaya Subramanian studies microRNA regulatory networks in sarcoma and other cancers.
Jeongsik Yong researches post-transcriptional regulation of mRNA processing in cancer.