Bioinspired Chemistry and Materials
Cells orchestrate with high efficiency a multitude of enzyme catalyzed chemical reactions that synthesize a tremendous diversity of chemical compounds that is unmatched by synthetic methods. We are interested in exploring and utilizing these biosynthetic machineries to enable the discovery sustainable synthesis of valuable compounds for use as fine chemicals, pharmaceuticals and chemical building blocks. Our lab is developing and studying systems to carry out multi-enzyme biocatalysis in vitro and in recombinant hosts for the synthesis of chemicals. By mixing and matching enzyme with desired catalytic activities identified from different sources, we are designing cascades of enzymatic reactions for the synthesis of compounds of interest.
Intrigued by the spatial organization of biological systems at the nano- to macro scale, we are investigating and eplxoring the principles that govern these process for the bottom-up design and low-cost fabrication of new types biomaterials. We are currently designing genetically programmable and self-assembling protein-based nanoarchitectures for biocatalysis and for the fabriction of novel functional bio(inorganic)-materials with emergent properties and functions.
Distinguished McKnight Professor
1479 Gortner Avenue
140 Gortner Laboratory
St. Paul, MN 55108