The MultiDrop Combi reagent dispenser combines the most versatile features for reagent dispensing with excellent performance for drug discovery or genomic and proteomic assays.

• Handles a wide selection of plates and volume ranges
• Provides fast dispensing and high-throughput operation
• Provides precise dispensing over a 0.5 to 2500μL range, ensuring reproducible assay data
• Visual icon-based graphic display makes it easy to use and program, even without training
• Minimal dead volume and back-flushing reduces reagent costs
• Uses eight-channel detachable and autoclavable dispensing cassettes that are standard across the Multidrop range

The Multidrop Combi Reagent Dispenser handles a wide selection of plates and volume range and provides fast dispensing and high-throughput operation.

Selected publications of instrument use

• Rebbeck R, Ginsburg KS, Ko CY, Fasoli A, Rusch K, Cai GF, Dong X, Thomas DD, Bers DM, Cornea RL. Synergistic FRET assays for drug discovery targeting RyR2 channels. J Mol Cell Cardiol. 2022 Jul;168:13-23. doi: 10.1016/j.yjmcc.2022.04.002. Epub 2022 Apr 9. PMID: 35405106; PMCID: PMC10088286.
• Zhang J, Singh DP, Ko CY, Nikolaienko R, Wong King Yuen SM, Schwarz JA, Treinen LM, Tung CC, Rožman K, Svensson B, Aldrich CC, Zima AV, Thomas DD, Bers DM, Launikonis BS, Van Petegem F, Cornea RL. Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. J Biol Chem. 2022 Jan;298(1):101412. doi: 10.1016/j.jbc.2021.101412. Epub 2021 Nov 16. PMID: 34793835; PMCID: PMC8689225.
• Nagamani Vunnam, Scott Hansen, Dillon C. Williams, MaryJane Olivia Been, Chih Hung Lo, Anil K. Pandey, Carolyn N. Paulson, John A. Rohde, David D. Thomas, Jonathan N. Sachs, and David K. Wood. Fluorescence Lifetime Measurement of Prefibrillar Sickle Hemoglobin Oligomers as a Platform for Drug Discovery in Sickle Cell Disease. Biomacromolecules 2022 23 (9), 3822-3830. DOI: 10.1021/acs.biomac.2c00671

Acknowledgements

The BTC should be acknowledged in any publications arising from the data analyzed in the BTC with the following text:

Experiments reported in this paper were performed at the Biophysical Technology Center, University of Minnesota Department of Biochemistry, Molecular Biology, and Biophysics.

Once published, please let us know via an email to umn-btc@umn.edu.

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