Quantitative analysis of the murine lipid droplet-associated proteome
Salmaan Ahmed Khan et al. J. Lipid Res. 2015;56:2260-2272
- Accumulation of lipid droplets is the defining feature of non-alcoholic fatty liver disease (NAFLD).
- Using iTRAQ labeling, the authors for the first time compared the proteome of hepatic lipid droplets of mice with or without NAFLD.
- The analysis identified proteins that were increased or decreased in abundance in lipids droplets in this disease model, thereby, providing
new insights and potential therapeutic targets towards NAFLD.