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Gianluigi Veglia

Professor

Expertise:


Veglia Lab Website


 

Research Description

The overall goal of my group is to study the structure and dynamics of membrane proteins and kinases. We use a multidisciplinary approach, which includes molecular biology, multidimensional solution and solid-state NMR spectroscopy, calorimetry and molecular modeling.


Recent Publications

Wang Y., Manu V.S., Kim J., Li G, Ahuja, L.G., Aoto, P., Taylor S.S., Veglia G. Globally correlated conformational entropy underlies positive and negative cooperativity in a Kinase‚Äôs enzymatic cycle. Nat. Commun. 2019

Gopinath T., Veglia G. Probing membrane protein ground and conformationally excited states using dipolar- and J-coupling mediated MAS solid state NMR experimentsMethods. 2018

Chipot C., Dehez F., Schnell J.R., Zitzmann N., Pebay-Peyroula E., Catoire L.J., Miroux B., Kunji E.R.S., Veglia G., Cross T.A., Schanda P.  Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical StudiesChem Rev. 2018

Kim J., Ahuja L.G., Chao F.A., Xia Y., McClendon C.L., Kornev A.P., Taylor S.S., Veglia G. A dynamic hydrophobic core orchestrates allostery in protein kinasesSci Adv. 2017

P:
612-625-0758
E:

vegli001@umn.edu

5-132 NHH
312 Church St. SE
Minneapolis, MN 55455