The overall goal of my group is to study the structure and dynamics of membrane proteins and kinases. We use a multidisciplinary approach, which includes molecular biology, multidimensional solution and solid-state NMR spectroscopy, calorimetry and molecular modeling.
Wang Y., Manu V.S., Kim J., Li G, Ahuja, L.G., Aoto, P., Taylor S.S., Veglia G. Globally correlated conformational entropy underlies positive and negative cooperativity in a Kinase’s enzymatic cycle. Nat. Commun. 2019
Gopinath T., Veglia G. Probing membrane protein ground and conformationally excited states using dipolar- and J-coupling mediated MAS solid state NMR experiments. Methods. 2018
Chipot C., Dehez F., Schnell J.R., Zitzmann N., Pebay-Peyroula E., Catoire L.J., Miroux B., Kunji E.R.S., Veglia G., Cross T.A., Schanda P. Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies. Chem Rev. 2018
Kim J., Ahuja L.G., Chao F.A., Xia Y., McClendon C.L., Kornev A.P., Taylor S.S., Veglia G. A dynamic hydrophobic core orchestrates allostery in protein kinases. Sci Adv. 2017