Ann V. Hertzel

My research interests include understanding the mechanistic basis of the pathologies associated with obesity, including insulin resistance, diabetes, cardiovascular disease, hyperlipidemia, endothelial dysfunction and hypertension.  Molecular and physiological studies have revealed that inflammation of adipose tissue is a key determinant in the initiation of these diseases.

Adipocytes and macrophages secrete proteins and lipids in a manner dependent on the current metabolic state.  With obesity there is an increased release of fatty acids from adipocytes and an increased production of proinflammatory cytokines and proinflammatory lipids in adipose tissue.  Additionally, adipocytes  secrete proteins known as adipokines which in a paracrine manner, affect insulin sensitivity.  With a mechanistic understanding of adipose biology, it will be possible to expand on therapeutic options for treatment of obesity related pathologies