David Zarkower

Lindeman, RE, Murphy, MW, Agrimson, KS, Gewiss, RL, Bardwell, VJ, Gearhart, MD, Zarkower, D (2021) The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming. Nucleic Acids Research 49:6144-6164

Weinberg P, Berkseth M, Zarkower D, Hobert O. (2018) Sexually Dimorphic unc-6/Netrin Expression Controls Sex-Specific Maintenance of Synaptic Connectivity. Current Biology 28:623-629

Nakagawa T, Zhang T, Kushi R, Nakano S, Endo T, Nakagawa M, Yanagihara N, Zarkower D., Nakayama K. (2017) Regulation of mitosis-meiosis transition by the ubiquitin ligase β-TrCP in male germ cells. Development 144(22):4137-4147.

Zhang T, Oatley J, Bardwell VJ, and Zarkower D. (2016) DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment. PLoS Genetics 12(9):e1006293.

Murphy, M.W., Lee, J.K., Rojo, S., Gearhart, M.D., Kurahashi, K., Banerjee, S., Loeuille, G.-A., Bashamboo, A., McElreavey, K., Zarkower, D., Aihara, H., and Bardwell, V.J. (2015) An ancient protein-DNA interaction underlying metazoan sex determination. Nature Structural and Molecular Biology 22:442-451.

Gamble, T., Coryell, J., Ezaz, T., Lynch, J., Scantlebury, D.P., and Zarkower, D. (2015) Restriction site-associated DNA sequencing (RAD-seq) reveals an extraordinary number of transitions among gecko sex-determining systems. Molecular Biology of Evolution 32:1296-1309.

Lindeman, R.E., Gearhart, M.D., Minkina, A., Bardwell, V.J., and Zarkower, D. (2015) Sexual cell fate reprogramming in the ovary by DMRT1. Current Biology 16:764-771.

Zhang, T., Murphy, M.W., Gearhart., M.D., Bardwell, V.J., and Zarkower, D. (2014) The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis. Development 141:3662-3671.

Minkina A, Matson CK, Lindeman RE, Ghyselinck NB, Bardwell VJ, Zarkower D. (2014) DMRT1 protects male gonadal cells from retinoid-dependent sexual transdifferentiation. Developmental Cell Jun 9;29(5):511-20.

Matson CK, Murphy MW, Sarver AL, Griswold MD, Bardwell VJ, Zarkower D. (2011) DMRT1 prevents female reprogramming in the postnatal mammalian testis. Nature Jul 20;476(7358):101-4.

Matson, C.K., Murphy, M.W., Griswold, M.D., Yoshida, S., Bardwell, V.J., and Zarkower, D. (2010) The mammalian Doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells. Developmental Cell 19:612-24.

Ross, J.M., Kalis, A., and D. Zarkower. (2005) The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins. Developmental Cell 8:881-892

Raymond, C.S., Murphy, M, O’Sullivan, M.G., Bardwell, V.J., and D. Zarkower (2000). Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes & Development 14:2587-2595.

Raymond, C.S., C. Shamu, M.M. Shen, K. Seifert, B. Hirsch, J. Hodgkin, and D. Zarkower (1998). Evidence for evolutionary conservation of sex-determining genes. Nature 391:691-695.

• BS, Pennsylvania State University, 1983
• PhD, University of Wisconsin-Madison, 1989
• Postdoctoral Fellow, Medical Research Council Laboratory of Molecular Biology, Cambridge, UK 1989-1994.