Juan Carlos Rivera-Mulia
Office Address

420 Washington Ave. S.E.
Minneapolis, MN 55455
United States

Juan Carlos


Assistant Professor
Biochemistry Molecular Biology and Biophysics

The human genome is organized in functional compartments that align with the temporal order of DNA replication. Research in the Rivera-Mulia lab focusses in identifying the regulatory elements of genome architecture, understanding how the specific folding patterns of the chromosomes evolve, and how altered chromosome architecture can disrupt gene function in disease.

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Selected publications


  • Rivera-Mulia, J. C., Trevilla-Garcia, C. and Martinez-Cifuentes, S. (2022). Optimized Repli-Seq: Improved DNA replication timing Analysis by next-generation sequencing. Chromosome Res. https://doi.org/10.1007/s10577-022-09703-7.
  • Rivera-Mulia, J. C., Sasaki, T., Trevilla-Garcia, C., Nakamichi, N., Knapp, D., Hammond, C., et al. (2019). Replication timing alterations in leukemia affect clinically-relevant chromosome domains. Blood Advances. 3(21):3201-3213. https://doi.org/10.1182/bloodadvances.2019000641.
  • Rivera-Mulia, J. C., Kim, S., Gabr, H., Chakraborty, A., Ay, F., Kahveci, T., Gilbert, D. M. (2019). Replication timing networks reveal a link between transcription regulatory circuits and replication timing control. Genome Research. 29(9):1415-1428. https://doi.org/10.1101/gr.247049.118.
  • Sima J, Chakraborty A, Dileep V, Michalski M, Klein KN, Holcomb NP, Turner J., Rivera-Mulia, J. C., et al. (2019) Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication. Cell. Feb 7;176(4):816–8. https://doi.org/10.1016/j.cell.2018.11.036.
  • Rivera-Mulia, J. C., Dimond, A., Vera, D., Trevilla-Garcia, C., Sasaki, T., Zimmerman, J., Dupont, C., Gribnau, J., Fraser, P., Gilbert D. M. (2018). Allele-specific control of replication timing and genome organization during development. Genome Research. 28(6), 800–811. https://doi.org/10.1101/gr.232561.117.
  • Rivera-Mulia, J. C., Schwerer, H., Besnard, E., Desprat, R., Trevilla-García, C., Sima, J., Bensadoun, P., Zouaoui, A,. Gilbert, D. M. Lemaitre, J. M. (2018). Cellular senescence induces replication stress with almost no affect on DNA replication timing. Cell Cycle. 17(13), 1667–1681. https://doi.org/10.1080/15384101.2018.1491235.
  • Rivera-Mulia, J. C., Desprat, R., Trevilla-Garcia, C., Cornacchia, D., Schwerer, H., Sasaki, T., Sima, J., Fells, T., Studer, L., Lemaitre, J. M., Gilbert, D. M. (2017). DNA replication timing alterations as a novel marker of progeroid diseases. Proc Natl Acad Sci USA. 114(51): E10972-E10980. https://doi.org/10.1073/pnas.1711613114.