Research interests:
Analysis of cyclic nucleotides and their biological functions as second messengers.

Selected publications

Goldberg, ND, Deitz, SB and O'Toole, AG. Cyclic guanosine 3',5'-monophosphate in mammalian tissues and urine. J. Biol. Chem. 244 , 4458, 1969

The first demonstration that cGMP is a natural constituent of mammalian tissue.

George, W. J. Polson, J. B., O'Toole, A. G. and Goldberg, N. D. Elevation of guanosine 3',5'-cyclic phosphate in rat heart after perfusion with acetylcholine. Proc. Natl. Acad. Sci. U S A. 66 , 398, 1970

The first evidence that cGMP and cAMP have independent regulatory roles.

Schafer, DE, Lust, WD, Sircar, B and Goldberg, ND. Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin. Proc. Natl. Acad. Sci. U S A, 67 , 851, 1970

The first evidence that cAMP mediates the toxic response to cholera toxin.

Walseth, TF, Graff, G, Krick, TP and Goldberg, ND. The fate of 18O in guanosine monophosphate during enzymic transformations leading to guanosine 3',5'-monophosphate generation. J Biol Chem. 256 , 2176, 1981

Walseth, TF, Gander, JA, Eide, SJ, Krick, TP and Goldberg, ND. 18O labeling of adenine nucleotide alpha-phosphoryls in platelets. Contribution by phosphodiesterase-catalyzed hydrolysis of cAMP. J Biol Chem., 258 , 1544, 1983

Descriptions of methods for the analysis of the kinetics of regulation by cyclic nucleotides.