Timothy Griffin

The goal of research in my group is to understand how proteins encoded in gene sequences contribute to normal biological processes in cells and how they change in human disease and cancer.  We use a technology called mass spectrometry to profile proteins present in cells, tissues, and biofluids, and specialized software to analyze the data produced and connect the behavior of proteins with changes to gene sequences that may cause disease. We also use these technologies to identify proteins made by bacteria that are found in humans to understand how these microbes may contribute to human health and disease. My group also seeks to train students and early-career scientists seeking careers in biomedical research and healthcare.

Work in the Griffin group focuses on developing mass spectrometry-based technologies for the molecular analysis of biological systems and disease. An additional emphasis is on the development of bioinformatic software tools (see galaxyp.org) for integrating multi-omics information — including genomic, transcriptomic, proteomic, and metabolomic data. Through collaborative, interdisciplinary research, we use these technologies and software to investigate molecular mechanisms underlying basic biology and translational studies of human disease and cancer, including contributions of the microbiome to these conditions.

Ph.D., University of Wisconsin, 1999

Postdoctoral Research, University of Washington and Institute for Systems Biology, 1999-2003