Wael Mostafa
612-205-7517
[email protected]
Office Address

1479 Gortner Avenue
St. Paul, MN 55108
United States

Wael Mostafa

Postdoctoral Associate
Biochemistry, Molecular Biology, and Biophysics,
BioTechnology Institute
Research Publications

My research focuses on drug discovery from natural sources, emphasizing the isolation, structural elucidation, and biological evaluation of bioactive metabolites from plants, microbes, and marine organisms. I have a particular interest in the chemistry, pharmacology, and genomics of extremophiles from extreme and environmentally challenging habitats — integrating bioinformatics to uncover biosynthetic gene clusters and novel therapeutically promising compounds.

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Research statement

  • Drug discovery from natural sources, including microbes, marine organisms, plants, etc.
  • Isolation of bioactive compounds from natural sources (plants, marine organisms, and microbial microorganisms, including bacteria and fungi) using bioassay-guided techniques. This includes the use of different chromatographic techniques, such as normal phase, reversed phase, HPLC, LCMS, gel permeation, etc.
  • Identification and structural elucidation of natural products using extensive 1D and 2D NMR, 15N NMR techniques, in addition to Mass Spectrometry.
  • Fermentation, biomass production of microbes (bacteria and fungi), in addition to the isolation and characterization of the secondary metabolites from the culture broth.
  • Microbial Biotransformation to produce new active entities.
  • Biological Screening and analysis, including antibacterial, cytotoxic, antioxidant, and lipoxygenase inhibition activity.
  • Microbial Genomics and Bioinformatics, including microbial genome sequencing and bioinformatics analysis to discover the biosynthetic gene clusters.

Education and background

  • Doctor of Philosophy in Natural Products Chemistry (Ph. D.), School of Natural and Computing Sciences, University of Aberdeen, Scotland, United Kingdom (2009)
  • Master of Pharmaceutical Sciences (Pharmacognosy) (M. Sc.), Faculty of Pharmacy, Assiut University, Assiut, Egypt (2003)
  • Bachelor of Pharmaceutical Sciences (B. Sc.), Faculty of Pharmacy, Assiut University, Assiut, Egypt (1997)