420 Washington Avenue SE
Minneapolis, MN 55455
We seek to discover the mechanisms that control translation, stability, and localization of mRNAs and to identify the networks of genes that are coordinately regulated by RNA-binding proteins and ribonucleases. Our discoveries are broadly relevant, with particular importance to stem cell and developmental biology. The results of our work will promote development of therapeutic approaches to correct deleterious gene expression in cancer and neurological diseases.
Mission Statement: Our goal is to discover the principles and mechanisms that control the expression of genetic information, with the benefit to society that this knowledge will enhance our understanding of the causes of disease and advance therapeutic strategies to correct deleterious gene expression.
Summary: Our goal is to understand how messenger RNAs are regulated. Regulation of translation, degradation and localization of mRNAs contributes to the enormous dynamic range of protein expression. Dysregulation can cause disease, developmental defects, or death. Sequence specific RNA-binding factors, both protein and small RNAs, play a central role in mRNA regulation. Our research focuses on two important classes of regulatory proteins: Pumilio proteins and deadenylases.