We are interested in understanding how cells handle energy stress for homeostasis, growth and survival. The cellular ability to coordinate the use of available energy is of fundamental importance, and many human diseases, such as cancer, diabetes, and neurodegenerative diseases, are affected by impairment of the coordination. Our main research focus is on energy- and nutrient-sensing mechanisms in cells via mTOR, and how the mechanisms operate to maintain energy and protein homeostasis.
