Office Address
1479 Gortner Avenue
Minneapolis, MN 55108
United States
Lawrence Wackett
Distinguished McKnight University Professor
Biochemistry, Molecular Biology, and Biophysics
The Wackett laboratory investigates enzyme transformations focusing on biodegradation, biocatalysis, and bioinformatics related to those topics. The biodegradation research is now directed toward the enzymatic degradation of guanidinium compounds and polyfluorinated compounds, know commonly as PFAS.
Research overview
The Wackett laboratory studies microbial enzymes and pathways for biocatalysis and biodegradation and helped build the Biocatalysis/Biodegradation Database.
Current biodegradation research
Research is being conducted on the biodegradation of PFAS chemicals. We are studying all aspects of the issue and developing new enzymes that handle these difficult-to-degrade chemicals. Research is also being conducted on the enzymatic degradation of guanidinium compounds such as the pharmaceutical metformin.
Bioremediation
Our studies on biodegradation provide opportunities for bioremediation of chemical contaminants in water; for example the disinfection byproduct cyanuric acid.
Bioinformatics
The Wackett laboratory is involved in a multi-investigator project to design the RAPID algorithm. RAPID is defined as Reactive Activity Product Identification and is a bioinformatics project designed to help predict the reactions catalyzed by broad-specificity enzymes that have significance in biosynthesis and biodegradation