Dr. Melanie Cobb
University of Texas Southwestern Medical Center
Dallas, TX
Wednesday, March 27, 2019
4:00-5:00 p.m.
2-137 Jackson Hall
Minneapolis Campus
"Catching a few good WNKs"
Background
Nelson D. Goldberg received his B.Sci. in 1953 from the University of Toledo and following military service at Walter Reed Army Institute of Research, a Ph.D. in 1962 from the University of Wisconsin. He conducted postdoctoral studies with Oliver Lowry at Washington University School of Medicine and moved to the University of Minnesota in 1964 as an Instructor in Pharmacology. He moved quickly through the academic ranks, becoming Professor of Pharmacology in 1972 and Professor of Biochemistry in 1987. His energy and enthusiasm for science were evidenced through his diverse research interests in the area of signal transduction and metabolic control.
During his 40+ year career, he studied TCA-cycle intermediates in the brain, effects of insulin on cyclic nucleotide metabolism in the muscle, and hormonal control of glycogen turnover in the liver. Perhaps his most noteworthy studies were on the synthesis and metabolism of cGMP and its relationship to cAMP mediated signaling events. He demonstrated regulated synthesis of cGMP in response to cholinergic stimulation and developed analytical methods to measure not only the synthesis of phosphorylated molecules, but also their degradation. His interest in "high-energy" phosphoryl compounds continued into the 1990's as he studied the role of adenylate kinase in phosphoryl transfer reactions.
Archive
| Year | Speaker/Affiliation | Title |
| 2018 |
Dr. Ron Kopito Stanford University, Stanford, CA |
Making the right choice: client specificity in ER protein quality control |
| 2017 |
Dr. Rosalind A. Coleman University of North Carolina, Chapel Hill, NC |
Lipid Regulation of β-adrenergic Receptor Signaling |
| 2016 |
Dr. Alan Saltiel University of California, San Diago, CA |
Inflammatory Links Between Obesity and Type 2 Diabetes |
| 2015 |
Dr. Karen Reue University of California, Los Angeles, CA |
Lipins, autophagy, and metabolic disease |
| 2014 |
Dr. Michael Marletta The Scripps Research Institute, LaJolla, CA |
Gas Sensing: From Bugs to Humans |
| 2013 |
Dr. Sheila Collins Sanford Burnham Medical Research Institute, Orlando, FL |
Converging Cyclic Nucleotide Second Messengers Regulate Fat Metabolism |
| 2012 |
Dr. Jackie Corbin Vanderbilt University Medical Center, Nashville, TN
|
Exploring Cyclic Nucleotide Action: Cyclic GMP, Penile Erection, & Viagra |
|
2011
|
Dr. Pere Puigserver |
Signaling Control of Mitochondrial Bioenergetics Through the PGC1 Pathway. |
|
2010
|
Dr. Joesph Beavo |
New roles for new and old phosphodiesterases. |
|
2009
|
Dr. Peter Roach |
Glycogen, and Old New Trick? From Multisite Protein in Phosphorylation to Glycogen Phosphorylation to Lafora Disease. |
|
2008
|
Dr. Christin Carter-Su |
The Role of the Tryosine Kinase JAK2 in Actions of Growth Hormone. |
|
2007
|
Dr. George Thomas |
Nutrient Sensing in the mTOR/S6K1 Signaling Pathway. |
|
2006
|
Dr. Christopher B. Newgard |
Comprehensive Metabolic Analysis to Identify Mechanisms of Diabetes and Obesity. |
|
2005
|
Dr. Barbara B. Kahn |
AMP-Activated Protein Kinase: Ancient fuel Gauge is a Key to Modern Understanding of Metabolism. |
|
2004
|
Dr. Morris J. Birnbaum |
The Coordinated Control of Growth and Metabolism. |
|
2003
|
Dr. M. Daniel Lane |
The Malonyl-CoA Hypothesis and Regulation of Energy Metabolism. |
|
2002
|
Dr. G. Stanley McKnight |
Physiological Functions of Protein Kinase A. |
|
2001
|
Dr. Tony Hunter |
Cellular Regulation by Phosphorylation and Ubiquitination. |
|
2000
|
Dr. David Garbers |
|
