BMBB Faculty

Structural biology of protein-nucleic acid interactions relevant to virology and cancer

We investigate inflammation and metabolic dysregulation in older individuals to generate mechanistic understanding of the pathways involved.

Functional proteomic analysis and biochemical characterization of metabolic-sensing PTMs in protein homeostasis, signaling and epigenetics

We take a systems and integrative biology approach to studying drug resistance in breast cancer

Molecular basis of muscular dystrophy

Research interests involve engaging students in structural biology/biophysics collaborations including instrument development, XRC, NMR, Cryo-EM/ET, etc.

We study the regulation of gene expression by RNA-binding proteins and ribonucleases during development and in diseases.

The Griffin group seeks to develop and apply mass spectrometry and bioinformatic technologies for the molecular analysis of biological systems and disease states.

Research focuses on understanding virus structure and function, specifically host-virus interactions that facilitate viral entry into cells.

Our group studies metabolic signaling mechanisms that drive epigenomic and transcriptional rhythms in healthy and metabolic disease states.

We study the relationships between chromatin modifications and gene regulation, and their impacts on human disease, particularly in cancer.

Engineering enzymes for applications in pharmaceutical synthesis, plastics recycling and as animal feed enzymes

Mechanisms that coordinate metabolic homeostasis

We use NMR spectroscopy and biochemical techniques to study the structures and dynamics that underlie the functions of macromolecular complexes

Our laboratory focuses on the relationship between lipid droplet biology and the development metabolic and aging related disease.

Integrative imaging approaches to investigate cell pathways exploited by RNA viruses; identify molecular targets for therapeutic interventions

The Muretta Lab investigates the molecular underpinnings of disease and uses what we learn to create new disease treatments.

Our research focuses on the contribution of individual differences in nicotine and carcinogen metabolism to lung cancer risk.

We develop in vitro and cell-based assays and substrate tools for post-translational modification enzymes using peptide chemical biology and proteomics.

Develop fluorescence-based protein biosensors for high-throughput screening and to resolve structural regulation of Ca2+ handling proteins.

Developmental regulation of genome architecture and function

We are developing biological systems for the sustainable synthesis of valuable compounds and fabrication of functional materials through biological design.

Synthetic Biology - Protein Evolution and Engineering - Artificial Proteins - Origin of Life - Astrobiology

We detect the molecular motions and interactions that are essential for cellular movement (e.g., muscle), focusing on applications to therapeutic discovery

We study cancer stem cells, signal transduction, gene regulation, cancer metabolism, post-translational modifications, breast cancer biology

We study the interactions between globular and membrane-associated proteins and enzymes involved in cardiac and skeletal muscle contractility.

The Wackett lab studies enzyme catalysis and its utility in biotechnology, focusing on bioremediation of PFAS, pesticides, and pharmaceuticals.

Structural enzymology; metals and organic cofactors.

We want to make people live longer and live healthier.

Cell signaling-mediated dynamics of regulatory transcriptome and functional proteome in cancer and metabolic diseases

We study the somatic genome and epigenome instability in aging and longevity applying single-cell multi-omics technologies.