Nelson D. Goldberg Lectureship Series

Dr. Melanie Cobb
University of Texas Southwestern Medical Center
Dallas, TX

Background

Nelson D. Goldberg received his B.Sci. in 1953 from the University of Toledo and following military service at Walter Reed Army Institute of Research, a Ph.D. in 1962 from the University of Wisconsin. He conducted postdoctoral studies with Oliver Lowry at Washington University School of Medicine and moved to the University of Minnesota in 1964 as an Instructor in Pharmacology. He moved quickly through the academic ranks, becoming Professor of Pharmacology in 1972 and Professor of Biochemistry in 1987. His energy and enthusiasm for science were evidenced through his diverse research interests in the area of signal transduction and metabolic control.

During his 40+ year career, he studied TCA-cycle intermediates in the brain, effects of insulin on cyclic nucleotide metabolism in the muscle, and hormonal control of glycogen turnover in the liver. Perhaps his most noteworthy studies were on the synthesis and metabolism of cGMP and its relationship to cAMP mediated signaling events. He demonstrated regulated synthesis of cGMP in response to cholinergic stimulation and developed analytical methods to measure not only the synthesis of phosphorylated molecules, but also their degradation. His interest in "high-energy" phosphoryl compounds continued into the 1990's as he studied the role of adenylate kinase in phosphoryl transfer reactions.

Archive

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