Thomas Lab Publications
To view citation information see Dave Thomas' Google Scholar profile.


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387. O Roopnarine and DD Thomas. 2023. Structural dynamics of protein interactions using site-directed spin labeling of cysteines to measure distances and rotational dynamics with EPR spectroscopy  Applied Magnetic Resonance. Accepted 9/22/23
386. Seflova J, Schwarz JA, Smith AN, Svensson B, Blackwell DJ, Phillips TA, Nikolaienko R, Bovo E, Rebbeck RT, Zima AV, Thomas DD, Van Petegem F, Knollmann BC, Johnston JN, Robia SL, and RL Cornea. 2023. RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET. Submitted June 21, 2023 to ACS Chem Biol. Accepted 9/8/23
385. Svensson, B, FR Nitu, RT Rebbeck, LM McGurran, T Oda, DD Thomas, DM Bers, and RL Cornea. 2023. Molecular Mechanism of a FRET Biosensor of the Cardiac Ryanodine Receptor Pathologically Leaky State. Int J Mol Sci. 24:254
384. Roopnarine, O*, SL Yuen*, AR Thompson, LN Roelike, RT Rebbeck, PA Bidwell, CC. Aldrich, RL Cornea, and DD Thomas. 2023. FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators. Scientific Reports 13:10673. 
383. Braun, AR, NN Kochen, SL Yuen, EE Liao, RL Cornea, DD Thomas, and JN Sachs. 2023. Advancements in a FRET biosensor for live-cell fluorescence-lifetime high-throughput screening of alpha-synuclein. ASN Neuroscience, 15:1-16.
382. Muretta, JM, D Rajasekaran, Y Blatt, S Little, M Myers, C Nair, B Burdekin, SL Yuen, N Jimenez, P Guhathakurta, A Wilson, AR Thompson, D Harden, CM Barbieri, L Adam, and DD Thomas. 2023. HTS driven by fluorescence lifetime detection of FRET identifies activators and inhibitors of cardiac myosin. SLAS Discovery 28: 223-232.
381. Atang, AE, RT Rebbeck, DD Thomas and AW Avery. 2023. Cardiomyopathy-Associated Variants Alter the Structure and Function of the α-Actinin-2 Actin-Binding Domain. BBRC . 670:12-18
380. Vunnam N, Young MC, Liao EE, Lo CH, Huber E, Been M, Thomas DD, Sachs JN. 2023. Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering. Cancer Biol Ther 24:2176692.
379. Ernst P, Bidwell PA, M Dora, DD Thomas, and F Kamdar. 2023. Calcium regulation in human induced pluripotent stem cell cardiomyocytes. Frontiers in Cell and Developmental Biology 10:986107
378. Guhathakurta, RT Rebbeck, PA Atang, AL Carter, SA Denha, B Svensson, DD Thomas, TS Hays, and AW Avery. 2023. Identification of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia. J Biol Chem 299:102956.
377. Rustad, MD*, O Roopnarine*, A Li, PD Martin, RL Cornea, and DD Thomas. 2023. Interaction of DWORF with SERCA and PLB determined by EPR. Biochem Biophys Res Commun 645:97-102. *Co-first-authors.
376. Nikolaienko R, E Bovo, SL Yuen, LM Treinen, K Berg, CC Aldrich, DD Thomas, RL Cornea and AV Zima. 2023. New N-aryl-N-alkyl-thiophene-2-carboxamide compound enhances intracellular Ca2+ dynamics by increasing SERCA2a Ca2+ pumping. Biophys J, Published online12/15/2022.
375. Bidwell, PA, SL Yuen, J Li, K Berg, RT Rebbeck, CC Aldrich, O Roopnarine, RL Cornea, and DD Thomas. 2022. A large-scale high-throughput screen for modulators of SERCA activity. Biomolecules 12:1789.
374. Young MC, N Vunnam, RT Rebbeck, SL Yuen, DD Thomas, and JN Sachs. 2022. Indirubin inhibits TRAIL-induced activation of death receptor 5 in Jurkat cells. Natural Product Communications 18:1-10.
373. Guhathakurta P, AL Carter, AR Thompson, D Kurila, J LaFrence, L Zhang, JR Trask, B Vanderheyden, JM Muretta, JM Ervasti and DD Thomas. 2022. Enhancing interaction of actin and actin-binding domain 1 of dystrophin with modulators: toward improved gene therapy for Duchenne muscular dystrophy. J Biol Chem 298:102675.
372. Vunnam, N, S Hansen, M Been, CH Lo, A Pandey, C Paulson, J Rohde, DD Thomas, J Sachs, D Wood.  2022 Fluorescence lifetime measurement of prefibrillar sickle hemoglobin oligomers as a platform for drug discovery in sickle cell disease. Biomacromolecules 23:3822-3830.
371. Simon, M, G Trombline, J Yang, EJ Earley, L Zhang, J Gigas, M Zagorulya, M Gilbert, PD Robbins, J Vijg, A Seluanov, Y Suh, B Garcia, DD Thomas, SL Yuen, A Pope, M Van Meter, S Emmrich, K Moody, N Barzilai, A Wolfe, G Atzmon, and V Gorbunova 2022. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. EMBO Journal 41:e110393.
370. Rebbeck, RT, KS Ginsburg, CY Ko, A Fasoli, K Rusch, GF Cai, X Dong, DD Thomas, DM Bers, RL Cornea. 2022. Synergistic FRET assays for drug discovery targeting RyR2 channels. JMCC 168:13-23.
369. Autry, JM, B Svensson, SF Carlson, Z Chen, RL Cornea, DD Thomas*, and SJ Valberg*. 2021. Sarcoplasmic reticulum from horse gluteal muscle is poised for enhanced calcium transport. Vet Sci. 8:289. 
368. Zhang, J, DP Singh, CY Ko, R Nikolaienko, SM Wong King Yuen, JA Schwarz, LM Treinen, CC Tung, K Rožman, B Svensson, CC Aldrich, AV Zima, DD Thomas, DM Bers, BS Launikonis, F Van Petegem, and RL Cornea. 2021. Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening.  J Biol Chem 298:101412
367. Chu, S, JM Muretta, and DD Thomas. 2021. Direct detection of the myosin super-relaxed state and interacting heads motif in solution. J Biol Chem 297:101157.
366. Karamafrooz A, J Brennan, DD Thomas, and LL Parker. 2021. Integrated phosphoproteomics for identifying substrates of human protein kinase A (PRKACA) and its oncogenic mutant DNAJB1-PRKACA. J. Proteome Res. 20:4815-4830.
365. Braun, AR, EE Liao, M Horvath, P Kalra, K Acosta, MC Young, NN Kochen, CH Lo, R Brown, MD Evans, WCK Pomerantz, E Rhoades, K Luk, L Cornea, DD Thomas, and JN Sachs. 2021. Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors. npj Parkinson’s Disease 7:52.
364. Weber, DK, UV Reddy, S Wang, EK Larsen, T Gopinath1, MB Gustavsson, RL Cornea, DD Thomas, A De Simone, and G Veglia. 2021. Structural basis for allosteric control of the SERCA-phospholamban membrane complex by Ca2+ and phosphorylation. eLife 2021;10:e66226.
363. Bunch, TA, P Guhathakurta, VC Lepak,  AR Thompson, R Kanassatega, A Wilson, DD Thomas, and BA Colson. 2021. Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen. J Biol Chem 297:100840.
362. Roopnarine, O, and DD Thomas. 2021. Mechanistic analysis of actin-binding compounds that affect the kinetics of cardiac myosin-actin interaction. J Biol Chem 296:100471. 
361. Li, A, SL Yuen, DR Stroik, E Kleinboehl, RL Cornea, and DD Thomas. 2021. The transmembrane peptide DWORF activates SERCA2a via dual mechanisms. J Biol Chem 296:100412. 
360. Olivieri, C, C Walker, A Karamafrooz, Y Wang, VS Manu, F Porcelli, DK Blumenthal, DD Thomas, DA Bernlohr, SM Sandford, SS Taylor, and G Veglia. 2021. Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A. Nature Commun Biol 4:321. 
359. Rebbeck, RT, AK Andrick, SA Denha, B Svensson, P Guhathakurta, DD Thomas, TS Hays, and AW Avery. 2021. Novel drug discovery platform for spinocerebellar ataxia, using fluorescence technology targeting β-III-spectrin. J Biol Chem 296: 100215.
358. Majumdar, A, DJ Burban, JM Muretta, AR Thompson, TA Engel, DM Rasmussen, MV Subrahmanian, G Veglia, DD Thomas and NM Levinson. 2021. Allostery governs Cdk2 activation and differential recognition of CDK inhibitors. Nat Chem Biol 17:456-464. 
357. Nelson, SED, DK Weber, RT Rebbeck, RL Cornea, GL Veglia, and DD Thomas. 2020. Met125 is essential for maintaining the structural integrity of calmodulin’s C-terminal domain. Nat Sci Rep 10:21320. 
356. Autry, JM, CB Karim, S Perumbakkam, CJ Finno, EC McKenzie, DD Thomas*, and SJ Valberg*. 2020. Sarcolipin exhibits abundant RNA transcription and minimal protein expression in horse gluteal muscle. Vet Sci 7:178. *Co-senior authors.
355. Gunther, LK, JA Rohde, W Tang, JA Cirilo, CP Marang, BD Scott, DD Thomas, EP Debold, and CM Yengo. 2020. FRET and optical trapping reveal mechanisms of actin activation of the power stroke and phosphate release in myosin V. J Biol Chem 295:17383-97. Selected as Editors’ Pick.
354. Phung, LA, AD Foster, MS Miller, DA Lowe, and DD Thomas. 2020. Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent. Am J Physiol Cell Physiol 319:C1158-C1162.
353. Autry, JM, CB Karim, M Cocco, SF Carlson, DD Thomas*, and SJ Valberg*. 2020. Purification of sarcoplasmic reticulum vesicles from horse gluteal muscle. Analyt Biochem 610:113965. *Co-senior authors.
352. Nikolaienko, R, E Bovo, RT Rebbeck, D Khan, DD Thomas, RL Cornea, and AV Zima. 2020. The functional significance of redox-mediated intersubunit cross-linking in regulation of human type 2 ryanodine receptor. Redox Biol 37:101729.
351. Guhathakurta, P, LA Phung, E Prochniewicz, S Lichtenberger, A Wilson and DD Thomas. 2020. Actin-binding compounds, previously discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle. J Biol Chem 295:14100-10.
350. Vetter AD, AA Martin, BR Thompson, DD Thomas, and JM Metzger. 2020. Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle. J Mol Cell Cardiol 147:49-61.
349. Lo, CH, NK Pandey, CK Lim, Z Ding, M Tao, DD Thomas, R Langen, and JN Sachs. 2020. Discovery of small molecule inhibitors of huntingtin exon 1 aggregation by FRET-based high-throughput screening in living cells. ACS Chem Neurosci 11:2286-95.
348. Schaaf, TM, E Kleinboehl, SL Yuen, LN Roelike, B Svensson, AR Thompson, RL Cornea, and DD Thomas. 2020. Live-Cell Cardiac-Specific High-Throughput Screening Platform for Drug-Like Molecules that Enhance Ca2+ Transport. Cells 9:1170.
347. Olivieri, C, Y Wang, GC Li, VS Manu, J Kim, BR Stultz, M Neibergall, F Porcelli, JM Muretta, DD Thomas, J Gao, DK Blumenthal, SS Taylor, and G Veglia. 2020. Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A. eLife 9:e55607.
346. Rebbeck, RT, DP Singh, KA Janicek, DD Thomas, DM Bers, BS Launikonis, and RL Cornea. 2020. RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. Nature Scientific Reports 10:1791.
345. Lindsay, AL, CW Baumann, RT Rebbeck, SL Yuen, MW Southern, JS Hodges, RL Cornea, DD Thomas, JM Ervasti, and DA Lowe. 2020. Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators. Skeletal Muscle 10:3.
344. McCarthy, MR, Y Savich, RL Cornea, and DD Thomas. 2020. Resolved structural states of calmodulin in regulation of skeletal muscle calcium release. Biophys J 118, 1090-1100.
343. Lo, CH, TM Schaaf, DD Thomas, and JN Sachs. 2020. Fluorescent TNFR1 biosensor for monitoring receptor structural and conformational dynamics and discovery of small molecule modulators. Methods Mol Biol, in press.
342. Stroik, DR, DK Ceholski, PA Bidwell, J Mleczko, PF Thanel, F Kamdar, JM Autry, RL Cornea, and DD Thomas. 2020. Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs. J Mol Cell Cardiol 138:59-65.
341. Martin, PD, B Svensson, DD Thomas, and S Stoll. 2019. Trajectory-based simulation of EPR spectra: models of rotational motion for spin labels on proteins. J Phys Chem B 123:10131-10141. 
340. Lo, CH, TM Schaaf, BD Grant, CKW Lim, P Bawaskar, CC Aldrich, DD Thomas, and JN Sachs. 2019. Noncompetitive inhibitors of TNFR1 probe conformational activation states. Sci Signal 12:eaav5637.
339. Binder, BP, AR Thompson, and DD Thomas. 2019. Atomistic models from orientation and distance constraints using EPR of a bifunctional spin label. Biophys J 117:319-330.
338. Savich, Y, BP Binder, AR Thompson, and DD Thomas. 2019. Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels. J Gen Physiol  151 (8): 1007–1016.
337. Lo, CH, CKW Lim, Z Ding, S Wickramasinghe, AR Braun, K Ashe, E Rhoades, DD Thomas, and JN Sachs. 2019. Targeting the ensemble of heterogeneous tau oligomers in cells: a novel small molecule screening platform for tauopathies. Alzheimer’s & Dementia 11:1489-1502.
336. Valberg, SJ, K Soave, ZJ Williams, S Perumbakkam, M Schott, CJ Finno, JL Petersen, C Fenger, JM Autry, and DD Thomas. 2019. Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis. J Vet Intern Med 33:933–941. 
335.             Gunther LK, JA Rohde, W Tang, SD Walton, WC Unrath, DV Trivedi, JM Muretta, DD Thomas, and CM Yengo. 2019. Converter domain mutations in myosin alter structural kinetics and motor function. J Biol Chem 294: 1554–1567.
334. Lake, EW, JM Muretta, AR Thompson, DM Rasmussen, A Majumdar, EB Faber, EF Ruff, DD Thomas, and NM Levinson. 2018. Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for aurora kinase activation states. Proc Natl Acad Sci U S A E11894–E11903.
333. Schaaf, TM, A Li, BD Grant, K Peterson, S Yuen, P Bawaskar, E Kleinboehl, J Li, DD Thomas, and GD Gillispie. 2018. Red-shifted FRET biosensors for high-throughput fluorescence lifetime screening. Biosensors 8:99.
332. Phung, LA, SM Karvinen, BA Colson, DD Thomas, and DA Lowe. 2018. Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice. PLoS One 13(9):e0199062.
331. Guhathakurta, P, Prochniewicz, E and DD Thomas. 2018. Actin-myosin interaction: structure, function and drug discovery. Int J Mol Sci 19:2628.
330. Stroik, DR, SL Yuen, KA Janicek, TM Schaaf,  J Li, DK Ceholski, RJ Hajjar, RL Cornea, and DD Thomas. 2018. Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells. Nature Sci Rep 8:12560.
329. Rohde, JA, O Roopnarine, DD Thomas, and JM Muretta. 2018. Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin. Proc Natl Acad Sci U S A 115:E7486-E7494.
328. Her, C, AR Thompson, CB Karim, and DD Thomas. 2018. Structural dynamics of calmodulin-ryanodine receptor interactions: electron paramagnetic resonance using stereospecific spin labels. Nature Sci Rep 8:10681.
327. Fealey, ME, B Horn, C Coffman, R Miller, AY Lin, AR Thompson, J Schramel, E Groth, A Hinderliter, A Cembran, and DD Thomas. 2018. Dynamics of dystrophin’s actin-binding domain. Biophys J 115:1-10.
326. Guhathakurta, P, E Prochniewicz, BD Grant, KC Peterson, and DD Thomas. 2018. High-throughput screen, using time-resolved FRET, yields actin-binding compounds that modulate actin-myosin structure and function. J Biol Chem 293:12288-12298. Cover article.
325. Ceholski, DK, IC Turnbull, CW Kong, S Koplev, J Mayourian, PA Gorski, F Stillitano, AA Skodras, M Nonnenmacher, N Cohen, JLM Björkegren, DR Stroik, RL Cornea, DD Thomas, RA Li, KD Costa, and RJ Hajjar. 2018. Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol 119:147-154.
324. Martin, PD, ZM James, JE McCaffrey, and DD Thomas. 2018. Effect of phosphorylation on interactions between transmembrane domains of SERCA and phospholamban. Biophys J 114:2573-2583.
323. Ruff, EF, JM Muretta, AR Thompson, EW Lake, S Cyphers, SK Albanese, SM Hanson, JM Behr, DD Thomas, JD Chodera, and NM Levinson. 2018. A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation. ELife 2018;7:e32766.

Nelson, SED, KN Ha, T Gopinath, MH Exline, A Mascioni, DD Thomas, G Veglia. 2018. Effects of the Arg9Cys and Arg25Cys mutations on phospholamban’s conformational equilibrium in membrane bilayers. Biochim Biophys Acta 1860:1335-1341.

320. O’Rourke, AR, A Lindsay, MD Tarpey, S Yuen, P McCourt, DM Nelson, BJ Perrin, DD Thomas, EE Spangenburg, DA Lowe, and JM Ervasti. 2018. Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms. FEBS J 285:481-500.
319. Fealey, ME, BP Binder, VN Uversky, A Hinderliter, and DD Thomas. 2018. Structural impact of phosphorylation and dielectric constant variation on synaptotagmin’s IDR. Biophys J 114:550-561.
318. Elam, WA, W Cao, H Kang, A Huehn, GM Hocky, E Prochniewicz, AC Schramm, K Negrón, J Garcia, TT Bonello, PW Gunning, DD Thomas, GA Voth, CV Sindelar, and EM De La Cruz. 2017. Phosphomimetic S3D cofilin binds but only weakly severs actin filaments. J Biol Chem 292:19565-19579.
317. Avery, AW, DD Thomas and TS Hays. 2017. β-III-spectrin spinocerebellar ataxia type 5 mutation reveals a dominant cytoskeletal mechanism that underlies dendritic arborization. Proc Natl Acad Sci U S A 114:E9376-E9385.
316. Avery, AW, ME Fealey, F Wang, A Orlova, AR Thompson, DD Thomas, TS Hays, and EH Egelman. 2017. Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation. Nature Commun 8:1350.
315. Vunnam, N, CH Lo, BD Grant, DD Thomas, and JN Sachs. 2017. Soluble extracellular domain of death receptor 5 inhibits TRAIL-induced apoptosis by disrupting receptor-receptor interactions. J Mol Biol 429:2943-2953.
314. Fealey, ME, DD Thomas, and A Hinderliter. 2017. Enhanced synaptotagmin plasticity derived from pairing intrinsic disorder with synaptic vesicle lipids. Commun Integr Biol 10:e1343772.
313. Lo, CH, N Vunnam, AK Lewis, TL Chiu, BE Brummel, TM Schaaf, BD Grant, P Bawaskar, DD Thomas, and JN Sachs. 2017. An innovative high-throughput screening approach for discovery of small molecules that inhibit TNF Receptors. SLAS Discov 22(8):950-961.
312. Guhathakurta, P, E Prochniewicz, O Roopnarine, JA Rohde, and DD Thomas. 2017. A cardiomyopathy mutation in the myosin essential light chain alters actomyosin structure. Biophys J 113:91-100.

Avery, AW, J Crain, DD Thomas, and TS Hays. 2016. A human β-III-spectrin spinocerebellar ataxia type 5 mutation causes high-affinity F-actin binding. Nature Sci Rep 6:21375.

299. Colson, BA, AR Thompson, LM Espinoza-Fonseca, and DD Thomas. 2016. Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics. Proc Natl Acad Sci U S A 456:151-155.
298. McCaffrey, JE, ZM James, B Svensson, BP Binder, and DD Thomas. 2016. A bifunctional spin label reports the structural topology of phospholamban in magnetically-aligned bicelles. J Magn Reson 262:50-56.
297. Svensson, B, JM Autry, and DD Thomas. 2016. Molecular modeling of fluorescent SERCA biosensors. P-Type ATPases, Methods Mol Biol  vol. 1377, Bublitz M. et al., editors. Humana Press, New York, NY. 503-522.
296. Muretta, JM, Y Jun, SP Gross, J Major, DD Thomas, and SS Rosenfeld. 2015. The structural kinetics of switch-1 and the neck linker explain the physiologies of Kinesin-1 and Eg5. Proc Natl Acad Sci U S A 112:E6606-E6613.
295. Trivedi, DV, JM Muretta, AM Swenson, JP Davis, DD Thomas, and CM Yengo. 2015. Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V. Proc Natl Acad Sci U S A 112:14593-14598.
294. Muretta, JM, JA Rohde, DO Johnsrud, S Cornea, and DD Thomas. 2015. Direct real-time detection of both structural and biochemical events in the myosin power stroke. Proc Natl Acad Sci U S A 112:14272-14277.
293. Karim, CB, LM Espinoza-Fonseca, ZM James, EA Hanse, JS Gaynes, DD Thomas, and A Kelekar. 2015. Structural mechanism for regulation of Bcl-2 protein Noxa by phosphorylation. Nature Sci Rep 5:14557.
292. Oda, T, Y Yang, H Uchinoumi, DD Thomas, Y Chen-Izu, T Kato, T Yamamoto, M Yano, RL Cornea, and DM Bers. 2015. Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter RyR structure and calmodulin affinity. J Mol Cell Cardiol 85:240-248.
291. Thompson, AR, BP Binder, JE McCaffrey, B Svensson, and DD Thomas. 2015. Bifunctional spin labeling of muscle proteins: accurate rotational dynamics, orientation, and distance by EPR. Methods Enzymol 564:102-123.
290. Alamo, L, X Li, LM Espinoza-Fonseca, A Pinto, DD Thomas, W Lehman, and R Padrón. 2015. Tarantula myosin free head regulatory light chain phosphorylation stiffens n-terminal extension permanently releasing it and blocking its docking back. Mol Biosyst 11:2180-2189.
289. Espinoza-Fonseca, LM, L Alamo, A Pinto, DD Thomas, and R Padrón. 2015. Sequential myosin phosphorylation activates tarantula thick filament via a disorder-order transition. Mol Biosyst 11:2167-2179.
288. Binder, BP, S Cornea, AR Thompson, RJ Moen, and DD Thomas. 2015. High-resolution helix orientation determined with a bifunctional spin label. Proc Natl Acad Sci U S A 112:7972-7977.
287. Espinoza-Fonseca LM, JM Autry, and DD Thomas. 2015. Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state. Biochem Biophys Res Commun 463:37-41.
286. Iram, SH, SJ Gruber, ON Raguimova, DD Thomas, and SL Robia. 2015. ATP-binding cassette transporter structure changes detected by intramolecular fluorescence energy transfer for high-throughput screening. Mol Pharmacol 88:84-94.
285. Espinoza-Fonseca, LM, JM Autry, GL Ramirez-Salinas, and DD Thomas. 2015. Atomic-level mechanisms for phospholamban regulation of the calcium pump. Biophys J 108:1697-1708.
284. Guhathakurta, P, E Prochniewicz, and DD Thomas. 2015. The amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain. Proc Natl Acad Sci U S A 112:4660-4665.
283. McCarthy, MR, AR Thompson, F Nitu, RJ Moen, JC Klein, and DD Thomas. 2015. Impact of methionine oxidation on calmodulin structural dynamics. Biochem Biophys Res Commun 456:567-572.
282. Colson, BA, KJ Petersen, BC Collins, DA Lowe, and DD Thomas. 2015. The myosin super-relaxed state is disrupted by estradiol deficiency. Biochem Biophys Res Commun 456:151-155.
281. Ablorh, NA and DD Thomas. 2015. Phospholamban phosphorylation, mutation, and structural dynamics: a biophysical approach to understanding and treating cardiomyopathy. Biophys Rev 7:63-76.
280. McCaffrey, JE, ZM James, and DD Thomas. 2015. Optimization of bicelle lipid composition and temperature for EPR spectroscopy of aligned membranes. J Magn Reson 250:71-75.
279. Petersen, KJ, KC Peterson, JM Muretta, SE Higgins, GD Gillispie, and DD Thomas. 2014. Fluorescence lifetime plate reader: resolution and precision meet high-throughput. Rev Sci Instrum 85:113101-113107.
278. Moen, RJ, S Cornea, DE Oseid, BP Binder, JC Klein, and DD Thomas. 2014. Redox-sensitive residue in the actin-binding interface of myosin.Biochem Biophys Res Commun 453:345-349.
277. Svensson, B, T Oda, FR Nitu, Y Yang, I Cornea, Y Chen-Izu, JD Fessenden, DM Bers, DD Thomas, and RL Cornea. 2014. FRET-based trilateration of probes bound within functional ryanodine receptors. Biophys J  107:2037-2048. Cover article.
276. Ablorh, NA, X Dong, ZM James, Q Xiong, J Zhang, DD Thomas, and CB Karim. 2014. Synthetic phosphopeptides enable quantitation of the content and function of the four phosphorylation states of phospholamban in cardiac muscle. J Biol Chem 289:29397-29405.
275. Espinoza-Fonseca, LM, BA Colson, and DD Thomas. 2014. Effects of pseudophosphorylation mutants on the structural dynamics of smooth muscle myosin regulatory light chain. Mol Biosyst 10:2693-2698.
274. Mahalingam, M, T Girgenrath, B Svensson, DD Thomas, RL Cornea*, and JD Fessenden*. 2014. Structural mapping of divergent regions in the type 1 ryanodine receptor using fluorescence resonance energy transfer. Structure 22:1322-1332. *co-senior authors.
273. Dong, X, and DD Thomas. 2014. Time-resolved FRET reveals the structural mechanism of SERCA-PLB regulation. Biochem Biophys Res Commun 449:196-201.
272. Espinoza-Fonseca, LM,  JM Autry, and DD Thomas. 2014. Microsecond molecular dynamics simulations of Mg2+- and K+- bound E1 intermediate states of the calcium pump. PLoS One 9:e95979.
271. Lewis, AK, ZM James, JE McCaffrey, AR Braun, CB Karim, DD Thomas, and JN Sachs. 2014. Open and closed conformations of the isolated transmembrane domain of death receptor 5 support a new model of activation. Biophys J 106:L21-L24.
270. Gruber, SJ, RL Cornea, J Li, KC Peterson, TM Schaaf, GD Gillispie, R Dahl, KM Zsebo, SL Robia, and DD Thomas. 2014. Discovery of enzyme modulators via high-throughput time-resolved FRET in living cells. J Biomol Screening 19:215-222.
269. Moen, RJ, JC Klein, and DD Thomas. 2014. Electron paramagnetic resonance resolves effects of oxidative stress on muscle proteins. Exerc Sport Sci Rev 42:30-36.
268. Greaser, ML, JD Potter, DD Thomas, GM Strasburg, SS Lehrer, C-LA Wang, and Z Grabarek.  2013. John Gergely (1919-2013): a pillar in the muscle protein field. J Muscle Res Cell Motil 34:441-446.
267. Muretta, JM, WM Behnke-Parks, J Major, KJ Petersen, A Goulet, CA Moores, DD Thomas, and SS Rosenfeld. 2013. Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5. J Biol Chem 288:34839-34849.
266. Bleeker, NP, RL Cornea, DD Thomas, and C Xing. 2013. A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML, Mol Pharm 10:4358–4366.
265. Pallikuth, S, DJ Blackwell, Z Hu, Z Hou, DT Zieman, B Svensson, DD Thomas, and SL Robia. 2013. Phosphorylated phospholamban stabilizes a compact conformation of the cardiac calcium-ATPase. Biophys J 105:1812-1821.
264. Muretta, JM, and DD Thomas. 2013. Mutation that causes hypertrophic cardiomyopathy increases force production in human beta-cardiac myosin. Proc Natl Acad Sci U S A 110:12507-12508.
263. Trivedi, DV, JM Muretta, AM Swenson, DD Thomas, and CM Yengo. 2013. Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle. Biochemistry 52:4710-4722.
262. Morgounova, E, Q Shao, BJ Hackel, DD Thomas and S Ashkenazi. 2013. Photoacoustic lifetime contrast between methylene blue monomers and self-quenched dimers as a model for dual-labeled activatable probes. J Biomed Opt 18:56004.
261. Muretta, JM, KJ Petersen, and DD Thomas. 2013. Direct real-time detection of the actin-activated power stroke within the myosin catalytic domain. Proc Natl Acad Sci U S A 110:7211–7216.
260. Prochniewicz, E, P Guhathakurta and DD Thomas. 2013. Structural dynamics of actin during active interaction with myosin depends on the isoform of the essential light chain. Biochemistry 52:1622−1630.
259. Moen, RJ, DD Thomas, and JC Klein. 2013. Conformationally trapping the actin-binding cleft of myosin with a bifunctional spin label. J Biol Chem 288:3016–3024.
258. Cornea, RL, SJ Gruber, EL Lockamy, JM Muretta, D Jin, J Chen, R Dahl, T Bartfai, KM Zsebo, GD Gillispie, and DD Thomas. 2012. High-throughput FRET assay yields allosteric SERCA activators. J Biomol Screen 18:97-107.
257. Sano, R, Y-CC Hou, M Hedvat, RG Correa, C-W Shu, M Krajewska, PW Diaz, CM Tamble, G Quarato, RA Gottlieb, M Yamaguchi, V Nizet, R Dahl, DD Thomas, SW Tait, DR Green, PB Fisher, S-I Matsuzawa, JC Reed. 2012. Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy. Genes Dev 26:1041-1054.
256. Colson, BA, IN Rybakova, E Prochniewicz, RL Moss, and DD Thomas. 2012. Cardiac myosin binding protein-C restricts intrafilament torsional dynamics of actin in a phosphorylation-dependent manner. Proc Natl Acad Sci U S A 109:20437-20442.
255. Autry, JM, JE Rubin, B Svensson, J Li, and DD Thomas. 2012. Nucleotide activation of the Ca-ATPase. J Biol Chem 287:39070–39082.
254. James, ZM, JE McCaffrey, KD Torgersen, CB Karim, and DD Thomas. 2012. Protein-protein interactions in calcium transport regulation probed by saturation transfer electron paramagnetic resonance. Biophys J 103:1370-1378.
253. Colson, BA, SJ Gruber, and DD Thomas. 2012. Structural dynamics of muscle protein phosphorylation. J Muscle Res Cell Motil 33:419-429.
252. Hou, Z, Z Hu, DJ Blackwell, TD Miller, DD Thomas, and SL Robia. 2012. 2-color calcium pump reveals closure of the cytoplasmic headpiece with calcium binding. PLoS One 7:e40369.
251. Guhathakurta, P, E Prochniewicz, JM Muretta, MA Titus, and DD Thomas. 2012. Allosteric communication in dictyostelium myosin II. J Muscle Res Cell Motil 33:305-312.
250. Valley, CC, AK Lewis, DJ Mudaliar, JD Perlmutter, AR Braun, CB Karim, DD Thomas, JR Brody, and JN Sachs. 2012. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized. J Biol Chem 287:21265-21278.
249. Lin, AY, E Prochniewicz, DM Henderson, B Li, JM Ervasti, and DD Thomas. 2012. Impacts of dystrophin and utrophin domains on actin structural dynamics: implications for therapeutic design. J Mol Biol 420:87-98.
248. Gruber, SJ, S Haydon, and DD Thomas. 2012. Phospholamban mutants compete with wild type for SERCA binding in living cells. Biochem Biophys Res Commun 420:236-240.
247. Li, J, ZM James, X Dong, CB Karim, and DD Thomas. 2012. Structural and functional dynamics of an integral membrane protein complex modulated by lipid headgroup charge. J Mol Biol 418:379-389.
246. Ablorh, NA, T Miller, F Nitu, SJ Gruber, CB Karim, and DD Thomas. 2012. Accurate quantitation of phospholamban phosphorylation by immunoblot. Analyt Biochem 425:68-75.
245. Henderson, DM, AY Lin, DD Thomas, and JM Ervasti. 2012. The carboxy-terminal third of dystrophin enhances actin binding activity. J Mol Biol 416:414–424.
244. Mello, RN, and DD Thomas. 2012. Three distinct actin-attached structural states of myosin in muscle fibers. Biophys J 102:1088–1096.
243. Karon, BS, CM van Buskirk, EA Jaben, JD Hoyer, and DD Thomas. 2012. Temporal sequence of major biochemical events during blood bank storage of packed red blood cells. Blood Transfus 10:453-461.
242. Thomas, DD, JM Muretta, BA Colson, RN Mello, and D Kast. 2012. Spectroscopic probes of muscle proteins. Comprehensive Biophysics. HE Egelman. Elsevier, Amsterdam, Netherlands. 226-250.
241. Klein, JC, RJ Moen, EA Smith, MA Titus, and DD Thomas. 2011. Structural and functional impact of site-directed methionine oxidation in myosin. Biochemistry 50:10318–10327.
240. Espinoza-Fonseca, LM, and DD Thomas. 2011. Atomic-level characterization of the activation mechanism of SERCA by calcium. PLoS One 6:e26936.
239. Prochniewicz, E, A Pierre, BR McCullough, HF Chin, W Cao, LP Saunders, DD Thomas, and EM De La Cruz. 2011. Actin filament dynamics in the actomyosin VI complex is regulated allosterically by calcium-calmodulin light chain. J Mol Biol 413:584-592.
238. Moen, RJ, DO Johnsrud, DD Thomas and MA Titus. 2011. Characterization of a myosin VII MyTH/FERM domain. J Mol Biol 413:17-23.
237. Autry, JM, JE Rubin, SD Pietrini, DL Winters, SL Robia, and DD Thomas. 2011. Oligomeric interactions of sarcolipin and the Ca-ATPase. J Biol Chem 286:31697-31706.
236. Lin, AY, E Prochniewicz, ZM James, B Svensson, and DD Thomas. 2011. Large-scale opening of utrophin’s tandem calponin homology (CH) domains upon actin binding by an induced-fit mechanism. Proc Natl Acad Sci U S A 108:12729–12733. 
235. Wilson, DJ, C Shi, BP Duckworth, JM Muretta, U Manjunatha, YY Sham, DD Thomas and CC Aldrich. 2011. A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis. Analyt Biochem 416:27-38.
234. Lockamy, EL, RL Cornea, CB Karim, and DD Thomas. 2011. Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure. Biochem Biophys Res Commun 408:388–392.
233. Gustavsson, M, NJ Traaseth, CB Karim, EL Lockamy, DD Thomas, and G Veglia. 2011. Lipid-mediated folding/unfolding of phospholamban as a regulatory mechanism for the sarcoplasmic reticulum calcium ATPase. J Mol Bio 408:755–765.
232. Nesmelov, YE, RV Agafonov, IV Negrashov, SE Blakely, MA Titus, and DD Thomas. 2011. Structural kinetics of myosin by transient time-resolved FRET. Proc Natl Acad Sci U S A 108:1891–1896.
231. Muretta, JM, A Kyrychenko, AS Ladokhin, DJ Kast, GD Gillispie, and DD Thomas. 2010. High -performance time-resolved fluorescence by direct waveform recording. Rev Sci Instrum 81:103101 (1-8).
230. Nesmelov, YE and DD Thomas. 2010. Protein structural dynamics revealed by site-directed spin labeling and multifrequency EPR. Biophys Rev 2:91-99.
229. Cornea, RL, FR Nitu, M Samso, DD Thomas and BR Fruen. 2010. Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer. J Biol Chem 285:19219-19226.
228. Kast, D, LM Espinoza-Fonseca, C Yi and DD Thomas. 2010. Phosphorylation-induced structural changes in smooth muscle myosin regulatory light chain. Proc Natl Acad Sci U S A 107:8207-8212.
227. Prochniewicz, E, HF Chin, A Henn, DE Hannemann, AO Olivares, DD Thomas, and EM De La Cruz. 2009. Myosin isoform determines the conformational dynamics and cooperativity of actin filaments in the strongly bound actomyosin complex. J Mol Biol 396:501-509.
226. Becucci, L, R Guidelli, CB Karim, DD Thomas, and G Veglia. 2009. The role of sarcolipin and ATP in the transport of phosphate ion into the sarcoplasmic reticulum. Biophys J 97:2693-2699.
225. Agafonov RV, IV Negrashov, YV Tkachev, SE Blakely, MA Titus, DD Thomas, and YE Nesmelov. 2009. Structural dynamics of the myosin relay helix by time-resolved EPR and FRET. Proc Natl Acad Sci U S A 106:21625-21630.
224. Hermanson, D, SN Addo, AA Bajer, JS Marchant, SGK Das, B Srinivasan, F Al-Mousa, F Michelangeli, DD Thomas, TW LeBien, and C Xing. 2009. Dual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria. Mol Pharmacol 76:667-678.
223. Becucci, L, A Cembran, CB Karim, DD Thomas, R Guidelli, J Gao, and G Veglia. 2009. On the function of pentameric phospholamban: ion channel or storage form? Biophys J 96:L60-62.
222. Balog, EM, EL Lockamy, DD Thomas, and DA Ferrington. 2009. Site-specific methionine oxidation initiates calmodulin degradation by the 20S proteasome. Biochemistry 48:3005-3016.
221. Prochniewicz, E, D Henderson, JM Ervasti and DD Thomas. 2009. Dystrophin and utrophin have distinct effects on the structural dynamics of actin. Proc Natl Acad Sci U S A 106:7822-7827.
220. Ablorh, NA, F Nitu, K Engebretsen, DD Thomas, and JS Holger. 2009. Insulin-dependent rescue from cardiogenic shock is not mediated by phospholamban phosphorylation. Clin Toxicol 47:296-302.
219. Cornea, RL, F Nitu, SJ Gruber, K Kohler, M Satzer, DD Thomas, and BR Fruen. 2009. FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel. Proc Natl Acad Sci U S A 106:6128-6133.
218. Karon, BS, JD Hoyer, JR Stubbs, and DD Thomas. 2009. Changes in band 3 oligomeric state precede cell membrane phospholipid loss during blood bank storage of red blood cells. Transfusion 49:1435-1442.
217. Thomas, DD, D Kast, and VL Korman. 2009. Site-directed spectroscopic probes of actomyosin structural dynamics. Annu Rev Biophys 38:347–369.
216. Mahaney, JE, DD Thomas, IK Farrance, and JP Froehlich. 2008. Intermolecular interactions in the mechanism of skeletal muscle sarcoplasmic reticulum Ca-ATPase (SERCA1): evidence for a triprotomer. Biochemistry 47:13711-13725.
215. Prochniewicz, E, D Spakowicz, and DD Thomas. 2008. Changes in actin structural transitions associated with oxidative inhibition of muscle contraction. Biochemistry 47:11811-11817.
214. Espinoza-Fonseca, LM, D Kast, and DD Thomas. 2008. Thermodynamic and structural basis of phosphorylation-induced disorder-to-order transition in the regulatory light chain of smooth muscle myosin. J Am Chem Soc 130:12208-12209.
213. Thompson, AR, N Naber, C Wilson, R Cooke, and DD Thomas. 2008. Structural dynamics of the actomyosin complex probed by a bifunctional spin label that cross-links SH1 and SH2. Biophys J  95:5238-5246.
212. Klein, JC, AR Burr, B Svensson, DJ Kennedy, J Allingham, MA Titus, I Rayment, and DD Thomas. 2008. Actin-binding cleft closure in myosin II probed by site-directed spin labeling and pulsed EPR. Proc Natl Acad Sci U S A 105:12867-12872.
211. Agafonov, RV, YE Nesmelov, MA Titus, and DD Thomas. 2008. Muscle and nonmuscle myosins probed by a spin label at equivalent sites in the force-generating domain. Proc Natl Acad Sci U S A 105:13397-13402.
210. Nesmelov, YE, RV Agafonov, AR Burr, RT Weber, and DD Thomas. 2008. Structure and dynamics of the force-generating domain of myosin probed by multifrequency electron paramagnetic resonance. Biophys J 95:247-256.
209. Winters, DL, JM Autry, B Svensson, and DD Thomas. 2008. Interdomain fluorescence resonance energy transfer in SERCA probed by cyan fluorescent protein fused to the actuator domain. Biochemistry 47:4246-4256.
208. Prochniewicz, E, DA Lowe, DJ Spakowicz, L Higgins, K O'Conor, LV Thompson, DA Ferrington, and DD Thomas. 2008. Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers. Am J Physiol Cell Physiol 294:C613-626.
207. Surek, JT, and DD Thomas. 2008. A paramagnetic molecular voltmeter. J Magn Reson 190:7-25.
206. Thomas, DD. 2007. A passion for wrestling. EPR Newsletter 17:6-7.
205. Robia, SL, KS Campbell, EM Kelly, Z Hou, DL Winters, and DD Thomas. 2007. Förster transfer recovery reveals that phospholamban exchanges slowly from pentamers but rapidly from the SERCA regulatory complex. Circ Res 101:1123-1129.
204. Ha, KN, NJ Traaseth, R Verardi, J Zamoon, A Cembran, CB Karim, DD Thomas, and G Veglia. 2007. Controlling the inhibition of the sarcoplasmic Ca2+-ATPase by tuning phospholamban structural dynamics. J Biol Chem 282:37205-37214.
203. Galdeen, SA, S Stephens, DD Thomas, and MA Titus. 2007. Talin influences the dynamics of the myosin VII-membrane interaction. Mol Biol Cell 18:4074-4084.
202. Traaseth, NJ, R Verardi, KD Torgersen, CB Karim, DD Thomas, and G Veglia. 2007. Spectroscopic validation of the pentameric structure of phospholamban. Proc Natl Acad Sci U S A 104:14676-14681.
201. Prochniewicz, E, LV Thompson, and DD Thomas. 2007. Age-related decline in actomyosin structure and function. Exp Gerontol 42:931-938.
200. Nesmelov, YE, CB Karim, L Song, PG Fajer, and DD Thomas. 2007. Rotational dynamics of phospholamban determined by multifrequency electron paramagnetic resonance. Biophys J 93:2805-2812.
199. Guidelli, R, L Becucci, CB Karim, DD Thomas and G Veglia. 2007. An electrochemical investigation of sarcolipin reconstituted into a mercury-supported lipid bilayer. Biophys J 93:2678-2687.
197. Espinoza-Fonseca, LM, D Kast, and DD Thomas. 2007. Molecular dynamics simulations reveal a disorder-to-order transition upon phosphorylation of smooth muscle myosin. Biophys J 93:2083-2090.
196. Karim, CB, Z Zhang, and DD Thomas. 2007. Synthesis of TOAC spin-labeled proteins and reconstitution in lipid membranes. Nature Protoc 2:42-49.
195. Zhang, Z, HA Remmer, DD Thomas, and CB Karim. 2007. Backbone dynamics determined by electron paramagnetic resonance to optimize solid-phase peptide synthesis of TOAC-labeled phospholamban. Biopolymers 88:29-35.
194. Lowe, DA, BO Williams, DD Thomas, and RW Grange. 2006. Molecular and cellular contractile dysfunction of dystrophic muscle from young mice. Muscle Nerve 34:92-100.
193. Traaseth, NJ, DD Thomas, and G Veglia. 2006. Effects of Ser16 phosphorylation on the allosteric transitions of phospholamban/Ca2+-ATPase complex. J Mol Biol 358:1041-1050.
192. Karim, CB, Z Zhang, EC Howard, KD Torgersen, and DD Thomas. 2006. Phosphorylation-dependent conformational switch in spin-labeled phospholamban bound to SERCA. J Mol Biol 358:1032-1040.
191. Buffy, JJ, BA Buck-Koehntop, F Porcelli, NJ Traaseth, DD Thomas, and G Veglia. 2006. Defining the intramembrane binding mechanism of sarcolipin to calcium ATPase using solution NMR spectroscopy. J Mol Biol 358:420-429.
190. Traverse, JH, YE Nesmelov, M Crampton, P Lindstrom, DD Thomas, and RJ Bache. 2006. Measurement of myocardial free radical production during exercise using EPR spectroscopy. Am J Physiol Heart Circ Physiol 290:H2453-2458.
189. Zhang, J, BJ Wallar, CV Popescu, DB Renner, DD Thomas, and JD Lipscomb. 2006. Methane monooxygenase hydroxylase and B component interactions. Biochemistry 45:2913-2926.
188. Nesmelov, YE, and DD Thomas. 2006. Multibore sample cell increases EPR sensitivity for aqueous samples. J Magn Reson 178:318-324.
187. Korman, VL, SEB Anderson, E Prochniewicz, MA Titus, and DD Thomas. 2006. Structural dynamics of the actin-myosin interface by site-directed spectroscopy. J Mol Biol 356:1107-1117.
186. Balog, EM, LE Norton, DD Thomas, and BR Fruen. 2006. Role of calmodulin methionine residues in mediating productive association with cardiac ryanodine receptors. Am J Physiol Heart Circ Physiol 290:H794-799.
185. Prochniewicz, E, N Janson, DD Thomas, and EM De La Cruz. 2005. Cofilin increases the torsional flexibility and dynamics of actin filaments. J Mol Biol 353:990-1000.
184. Prochniewicz, E, DD Thomas, and LV Thompson. 2005. Age-related decline in actomyosin function. J Gerontol A Biol Sci Med Sci 60A:425-431.
183. Paterlini, MG, and DD Thomas. 2005. The alpha-helical propensity of the cytoplasmic domain of phospholamban: a molecular dynamics simulation of the effect of phosphorylation and mutation. Biophys J 88:3243-3251.
182. Robia, SL, NC Flohr, and DD Thomas. 2005. Phospholamban pentamer quaternary conformation determined by in-gel fluorescence anisotropy.Biochemistry 44:4302-4311.
181. Zamoon, J, F Nitu, CB Karim, DD Thomas, and G Veglia. 2005. Mapping the interaction surface of a membrane protein: unveiling the conformational switch of phospholamban in calcium pump regulation. Proc Natl Acad Sci U S A 102:4747-4752.
180. Nelson, WD, SE Blakely, YE Nesmelov, and DD Thomas. 2005. Site-directed spin labeling reveals a conformational switch in the phosphorylation domain of smooth muscle myosin. Proc Natl Acad Sci U S A 102:4000-4005.
179. Fruen, BR, EM Balog, J Schafer, FR Nitu, DD Thomas, and RL Cornea. 2005. Direct detection of calmodulin tuning by ryanodine receptor channel targets using a Ca2+-sensitive acrylodan-labeled calmodulin. Biochemistry 44:278-284.
178. Karim, CB, TL Kirby, Z Zhang, Y Nesmelov, and DD Thomas. 2004. Phospholamban structural dynamics in lipid bilayers probed by a spin label rigidly coupled to the peptide backbone. Proc Natl Acad Sci U S A 101:14437-14442.
177. Mueller, B, M Zhao, IV Negrashov, R Bennett, and DD Thomas. 2004. SERCA structural dynamics induced by ATP and calcium. Biochemistry 43:12846-12854.
176. Prochniewicz, E, TF Walseth, and DD Thomas. 2004. Structural dynamics of actin during active interaction with myosin: different effects of weakly and strongly bound myosin heads. Biochemistry 43:10642-10652.
175. Metcalfe, EE, J Zamoon, DD Thomas, and G Veglia. 2004. 1H/15N Heteronuclear NMR spectroscopy shows four dynamic domains for phospholamban reconstituted in dodecylphosphocholine micelles. Biophys J  87:1205-1214.
174. Mueller, B, CB Karim, IV Negrashov, H Kutchai, and DD Thomas. 2004. Direct detection of phospholamban and sarcoplasmic reticulum Ca-ATPase interaction in membranes using fluorescence resonance energy transfer. Biochemistry  43:8754-8765.
173. Kirby, TL, CB Karim, and DD Thomas. 2004. Electron paramagnetic resonance reveals a large-scale conformational change in the cytoplasmic domain of phospholamban upon binding to the sarcoplasmic reticulum Ca-ATPase. Biochemistry  43:5842-5852.
172. Mahaney, JE, DD Thomas, and JP Froehlich. 2004. The time-dependent distribution of phosphorylated intermediates in native sarcoplasmic reticulum Ca2+-ATPase from skeletal muscle is not compatible with a linear kinetic model. Biochemistry  43:4400-4416.
171. Nesmelov, YE, A Gopinath, and DD Thomas. 2004. Aqueous sample in an EPR cavity: sensitivity considerations. J Magn Reson 167:138-146.
170. Lowe, DA, GL Warren, LM Snow, LV Thompson, and DD Thomas. 2004. Muscle activity and aging affect myosin structural distribution and force generation in rat fibers. J Appl Physiol 96:498-506.
169. Zamoon, J, A Mascioni, DD Thomas, and G Veglia. 2003. NMR solution structure and topological orientation of monomeric phospholamban in dodecylphosphocholine micelles. Biophys J  85:2589-2598.
168. LaConte, LE, JE Baker, and DD Thomas. 2003. Transient kinetics and mechanics of myosin's force-generating rotation in muscle: resolution of millisecond rotational transitions in the spin-labeled myosin light-chain domain. Biochemistry 42:9797-9803.
167. Buck, B, J Zamoon, TL Kirby, TM DeSilva, CB Karim, DD Thomas, and G Veglia. 2003. Overexpression, purification, and characterization of recombinant Ca-ATPase regulators for high-resolution solution and solid-state NMR studies. Protein Expr Purif 30:253-261.
166. Balog, EM, LE Norton, RA Bloomquist, RL Cornea, DJ Black, CF Louis, DD Thomas, and BR Fruen. 2003. Calmodulin oxidation and methionine to glutamine substitutions reveal methionine residues critical for functional interaction with ryanodine receptor-1. J Biol Chem 278:15615-15621.
165. Reddy, LG, RL Cornea, DL Winters, E McKenna, and DD Thomas. 2003. Defining the molecular components of calcium transport regulation in a reconstituted membrane system. Biochemistry 42:4585-4592.
164. Lockwood, NA, RS Tu, Z Zhang, MV Tirrell, DD Thomas, and CB Karim. 2003. Structure and function of integral membrane protein domains resolved by peptide-amphiphiles: application to phospholamban. Biopolymers 69:283-292.
163. Lidke, DS, and DD Thomas. 2002. Coordination of the two heads of myosin during muscle contraction. Proc Natl Acad Sci U S A 99:14801-14806.
162. Mascioni, A, C Karim, J Zamoon, DD Thomas, and G Veglia. 2002. Solid-state NMR and rigid body molecular dynamics to determine domain orientations of monomeric phospholamban. J Am Chem Soc 124:9392-9393.
161. LaConte, LEW, V Voelz, W Nelson, M Enz, and DD Thomas. 2002. Molecular dynamics simulation of site-directed spin labeling: experimental validation in muscle fibers. Biophys J 83:1854-1866.
160. Nocek, JM, SL Hatch, JL Seifert, GW Hunter, DD Thomas, and BM Hoffman. 2002. Interprotein electron transfer in a confined space: uncoupling protein dynamics from electron transfer by sol-gel encapsulation. J Am Chem Soc 124:9404-9411.
159. Lowe, DA, DD Thomas, and LV Thompson. 2002. Force generation, but not myosin ATPase activity, declines with age in rat muscle fibers. Am J Physiol Cell Physiol 283:C187-192.
158. Mascioni, A, C Karim, G Barany, DD Thomas, and G Veglia. 2002. Structure and orientation of sarcolipin in lipid environments. Biochemistry 41:475-482.
157. Thomas, DD, E Prochniewicz, and O Roopnarine. 2002. Changes in actin and myosin structural dynamics due to their weak and strong interactions. Results Probl  Cell Differ 36:7-19.
156. Thomas, DD, and O Roopnarine, Eds. 2002. Molecular interactions of actin. Actin-myosin interaction and actin-based regulation. Results and Problems in Cell Differentiation, Springer Verlag, Berlin, Germany. 1-5
155. dos Remedios, CG, and DD Thomas, Eds. 2001. Molecular interactions of actin. Actin structure and actin-binding proteins. Results and Problems in Cell Differentiation, Springer Verlag, Berlin, Germany. 1-7
154. Prochniewicz, E, and DD Thomas. 2001. Site-specific mutations in the myosin binding sites of actin affect structural transitions that control myosin binding. Biochemistry 40:13933-13940.
153. Nesmelov, YE, JT Surek, and DD Thomas. 2001. Enhanced EPR sensitivity from a ferroelectric cavity insert. J Magn Reson 153:7-14.
152. Karim, CB, MG Paterlini, LG Reddy, GW Hunter, G Barany, and DD Thomas. 2001. Role of cysteine residues in structural stability and function of a transmembrane helix bundle. J Biol Chem 276:38814-38819.
151. Hellstern, S, S Pegoraro, CB Karim, A Lustig, DD Thomas, L Moroder, and J Engel. 2001. Sarcolipin, the shorter homologue of phospholamban, forms oligomeric structures in detergent micelles and in liposomes. J Biol Chem 276:30845-30852.
150. Orlova, A, IN Rybakova, E Prochniewicz, DD Thomas, JM Ervasti, and EH Egelman. 2001. Binding of dystrophin's tandem calponin homology domain to F-actin is modulated by actin's structure. Biophys J  80:1926-1931.
149. Thompson, LV, DA Lowe, DA Ferrington, and DD Thomas. 2001. Electron paramagnetic resonance: a high-resolution tool for muscle physiology. Exerc Sport Sci Rev 29:3-6.
148. Lowe, DA, JT Surek, DD Thomas, and LV Thompson. 2001. Electron paramagnetic resonance reveals age-related myosin structural changes in rat skeletal muscle fibers. Am J Physiol Cell Physiol 280:C540-547.
147. Baker, JE, and DD Thomas. 2000. A thermodynamic muscle model and a chemical basis for A.V. Hill's muscle equation. J Muscle Res Cell Motil 21:335-344.
146. Karim, CB, CG Marquardt, JD Stamm, G Barany, and DD Thomas. 2000. Synthetic null-cysteine phospholamban analogue and the corresponding transmembrane domain inhibit the Ca-ATPase. Biochemistry 39:10892-10897.
145. Baker, JE, and DD Thomas. 2000. Thermodynamics and kinetics of a molecular motor ensemble. Biophys J 79:1731-1736.
144. Baker, JE, LE LaConte, DD Thomas, and I Brust-Mascher. 2000. Muscle chemistry and force. Biophys J 79:1687-1688.
143. Baker, JE, I Brust-Mascher, LE LaConte, and DD Thomas. 2000. Mechanochemical coupling in muscle. Biophys J 78:2730.
142. Karim, CB, LG Reddy, GW Hunter, YM Angell, G Barany, and DD Thomas. 2000. Chemical approach for evaluating role of the cysteine residues in pentameric phospholamban structure: effect on sarcoplasmic reticulum. Proceedings of the Sixteenth American Peptide Symposium. Kluwer Academic Publishers, Dordrecht, Netherlands.
141. Prochniewicz, E, and DD Thomas. 1999. Differences in structural dynamics of muscle and yeast actin accompany differences in functional interactions with myosin. Biochemistry 38:14860-14867.
140. Baker, JE, LE LaConte, I Brust-Mascher, and DD Thomas. 1999. Mechanochemical coupling in spin-labeled, active, isometric muscle. Biophys J 77:2657-2664.
139. Brust-Mascher, I, LE LaConte, JE Baker, and DD Thomas. 1999. Myosin light-chain domain rotates upon muscle activation but not ATP hydrolysis. Biochemistry 38:12607-12613.
138. Karon, BS, JM Autry, Y Shi, CE Garnett, G Inesi, LR Jones, H Kutchai, and DD Thomas. 1999. Different anesthetic sensitivities of skeletal and cardiac isoforms of the Ca-ATPase. Biochemistry 38:9301-9307.
137. Ramachandran, S, and DD Thomas. 1999. Rotational dynamics of the regulatory light chain in scallop muscle detected by time-resolved phosphorescence anisotropy. Biochemistry 38:9097-9104.
136. Reddy, LG, Y Shi, H Kutchai, AG Filoteo, JT Penniston, and DD Thomas. 1999. An autoinhibitory peptide from the erythrocyte Ca-ATPase aggregates and inhibits both muscle Ca-ATPase isoforms. Biophys J 76:3058-3065.
135. Li, M, LG Reddy, R Bennett, ND Silva, Jr, LR Jones, and DD Thomas. 1999. A fluorescence energy transfer method for analyzing protein oligomeric structure: application to phospholamban. Biophys J 76:2587-2599.
134. Reddy, LG, JM Autry, LR Jones, and DD Thomas. 1999. Co-reconstitution of phospholamban mutants with the Ca-ATPase reveals dependence of inhibitory function on phospholamban structure. J Biol Chem 274:7649-7655.
133. Reddy, LG, LR Jones, and DD Thomas. 1999. Depolymerization of phospholamban in the presence of calcium pump: a fluorescence energy transfer study. Biochemistry 38:3954-3962.
132. Roopnarine, O, AG Szent-Gyorgyi, and DD Thomas. 1998. Microsecond rotational dynamics of spin-labeled myosin regulatory light chain induced by relaxation and contraction of scallop muscle. Biochemistry 37:14428-14436.
131. Karim, CB, JD Stamm, J Karim, LR Jones, and DD Thomas. 1998. Cysteine reactivity and oligomeric structures of phospholamban and its mutants. Biochemistry 37:12074-12081.
130. Thomas, DD, LG Reddy, CB Karim, M Li, RL Cornea, JM Autry, LR Jones, and J Stamm. 1998. Direct spectroscopic detection of molecular dynamics and interactions of the calcium pump and phospholamban. Ann N Y Acad Sci 853:186-194.
129. Li, M, RL Cornea, JM Autry, LR Jones, and DD Thomas. 1998. Phosphorylation-induced structural change in phospholamban and its mutants, detected by intrinsic fluorescence. Biochemistry 37:7869-7877.
128. Corrie, JET, JE Baker, EM Ostap, DD Thomas, and DR Trentham. 1998. Transient free radicals are formed during photolysis of the 1-(2-nitrophenyl) ethyl ester of adenosine triphosphate (caged ATP). J Photochem Photobiol 115:49-55.
127. Kutchai, H, LM Geddis, LR Jones, and DD Thomas. 1998. Differential effects of general anesthetics on the quaternary structure of the Ca-ATPases of cardiac and skeletal sarcoplasmic reticulum. Biochemistry 37:2410-2421.
126. Baker, JE, I Brust-Mascher, S Ramachandran, LE LaConte, and DD Thomas. 1998. A large and distinct rotation of the myosin light chain domain occurs upon muscle contraction. Proc Natl Acad Sci U S A 95:2944-2949.
125. Froehlich, JP, K Taniguchi, K Fendler, JE Mahaney, DD Thomas, and RW Albers. 1997. Complex kinetic behavior in the Na, K- and Ca-ATPases evidence for subunit-subunit interactions and energy conservation during catalysis. Ann N Y Acad Sci 834:280-296.
124. Prochniewicz, E, and DD Thomas. 1997. Perturbations of functional interactions with myosin induce long-range allosteric and cooperative structural changes in actin. Biochemistry 36:12845-12853.
123. Cornea, RL, LR Jones, JM Autry, and DD Thomas. 1997. Mutation and phosphorylation change the oligomeric structure of phospholamban in lipid bilayers. Biochemistry 36:2960-2967.
122. Kleinschmidt, JH, JE Mahaney, DD Thomas, and D Marsh. 1997. Interaction of bee venom melittin with zwitterionic and negatively charged phospholipid bilayers: a spin-label electron spin resonance study. Biophys J 72:767-778.
121. Shi, Y, BS Karon, H Kutchai, and DD Thomas. 1996. Phospholamban-dependent effects of C12E8 on calcium transport and molecular dynamics in cardiac sarcoplasmic reticulum. Biochemistry 35:13393-13399.
120. Prochniewicz, E, Q Zhang, PA Janmey, and DD Thomas. 1996. Cooperativity in F-actin: binding of gelsolin at the barbed end affects structure and dynamics of the whole filament. J Mol Biol 260:756-766.
119. Roopnarine, O, and DD Thomas. 1996. Orientation of intermediate nucleotide states of indane dione spin-labeled myosin heads in muscle fibers. Biophys J 70:2795-2806.
118. Prochniewicz, E, Q Zhang, EC Howard, and DD Thomas. 1996. Microsecond rotational dynamics of actin: spectroscopic detection and theoretical simulation. J Mol Biol 255:446-457.
117. Ostap, EM, VA Barnett, and DD Thomas. 1995. Resolution of three structural states of spin-labeled myosin in contracting muscle. Biophys J 69:177-188.
116. Karon, BS, ER Nissen, J Voss, and DD Thomas. 1995. A continuous spectrophotometric assay for simultaneous measurement of calcium uptake and ATP hydrolysis in sarcoplasmic reticulum. Analyt Biochem 227:328-333.
115. Voss, JC, JE Mahaney, LR Jones, and DD Thomas. 1995. Molecular dynamics in mouse atrial tumor sarcoplasmic reticulum. Biophys J 68:1787-1795.
114. Roopnarine, O, and DD Thomas. 1995. Orientational dynamics of indane dione spin-labeled myosin heads in relaxed and contracting skeletal muscle fibers. Biophys J 68:1461-1471.
113. Mahaney, JE, JP Froehlich, and DD Thomas. 1995. Conformational transitions of the sarcoplasmic reticulum Ca-ATPase studied by time-resolved EPR and quenched-flow kinetics. Biochemistry 34:4864-4879.
112. Thomas, DD, S Ramachandran, O Roopnarine, DW Hayden, and EM Ostap. 1995. The mechanism of force generation in myosin: a disorder-to-order transition, coupled to internal structural changes. Biophys J 68:135S-141S.
111. Karon, BS, LM Geddis, H Kutchai, and DD Thomas. 1995. Anesthetics alter the physical and functional properties of the Ca-ATPase in cardiac sarcoplasmic reticulum. Biophys J 68:936-945.
110. Voss, JC, JE Mahaney, and DD Thomas. 1995. Mechanism of Ca-ATPase inhibition by melittin in skeletal sarcoplasmic reticulum. Biochemistry 34:930-939.
109. Mersol, JV, H Kutchai, JE Mahaney, and DD Thomas. 1995. Self-association accompanies inhibition of Ca-ATPase by thapsigargin. Biophys J 68:208-215.
108. Karon, BS, JE Mahaney, and DD Thomas. 1994. Halothane and cyclopiazonic acid modulate Ca-ATPase oligomeric state and function in sarcoplasmic reticulum. Biochemistry 33:13928-13937.
107. Kutchai, H, JE Mahaney, LM Geddis, and DD Thomas. 1994. Hexanol and lidocaine affect the oligomeric state of the Ca-ATPase of sarcoplasmic reticulum. Biochemistry 33:13208-13222.
106. Roopnarine, O, and DD Thomas. 1994. A spin label that binds to myosin heads in muscle fibers with its principal axis parallel to the fiber axis. Biophys J 67:1634-1645.
105. Thomas, DD, and BS Karon. 1994. Temperature dependence of molecular dynamics and calcium-ATPase activity in sarcoplasmic reticulum. The Temperature Adaptation of Biological Membranes. AR Cossins. Portland Press, London, England. 1-12.
104. Berger, CL, and DD Thomas. 1994. Rotational dynamics of actin-bound intermediates of the myosin adenosine triphosphatase cycle in myofibrils. Biophys J 67:250-261.
103. Voss, J, LR Jones, and DD Thomas. 1994. The physical mechanism of calcium pump regulation in the heart. Biophys J 67:190-196.
102. Thomas, DD. 1994. Angular disorder of weak-binding actomyosin cross-bridges. Biophys J 66:1272-1273.
101. Cornea, RL, and DD Thomas. 1994. Effects of membrane thickness on the molecular dynamics and enzymatic activity of reconstituted Ca-ATPase. Biochemistry 33:2912-2920.
100. Naber, N, EM Ostap, DD Thomas, and R Cooke. 1993. Orientation and rotational dynamics of spin-labeled phalloidin bound to actin in muscle fibers. Proteins 17:347-354.
99. Birmachu, W, JC Voss, CF Louis, and DD Thomas. 1993. Protein and lipid rotational dynamics in cardiac and skeletal sarcoplasmic reticulum detected by EPR and phosphorescence anisotropy. Biochemistry 32:9445-9453.
98. Karon, BS, and DD Thomas. 1993. Molecular mechanism of Ca-ATPase activation by halothane in sarcoplasmic reticulum. Biochemistry 32:7503-7511.
97. Ostap, EM, HD White, and DD Thomas. 1993. Transient detection of spin-labeled myosin subfragment 1 conformational states during ATP hydrolysis. Biochemistry 32:6712-6720.
96. Prochniewicz, E, E Katayama, T Yanagida, and DD Thomas. 1993. Cooperativity in F-actin: chemical modifications of actin monomers affect the functional interactions of myosin with unmodified monomers in the same actin filament. Biophys J 65:113-123.
95. Thomas, DD. 1993. Blitz and blizzard: crossbridges and chaos. Biophys J 65:21-22.
94. Roopnarine, O, K Hideg, and DD Thomas. 1993. Saturation transfer electron parametric resonance of an indane-dione spin-label calibration with hemoglobin and application to myosin rotational dynamics. Biophys J 64:1896-1907.
93. Thomas, DD, and JE Mahaney. 1993. The functional effects of protein and lipid dynamics in sarcoplasmic reticulum. Protein-Lipid Interactions. A Watt, Elsevier, Amsterdam, Netherlands. 25:301-320.
92. Thomas, DD, EM Ostap, CL Berger, SM Lewis, PG Fajer, and JE Mahaney. 1993. Transient EPR of spin-labeled proteins. EMR of Paramagnetic Molecules. LJ Berliner and J Reuben. Plenum Press, New York, NY. 323-349.
91. Berger, CL, and DD Thomas. 1993. Rotational dynamics of actin-bound myosin heads in active myofibrils. Biochemistry 32:3812-3821.
90. Howard, EC, KM Lindahl, CF Polnaszek, and DD Thomas. 1993. Simulation of saturation transfer electron paramagnetic resonance spectra for rotational motion with restricted angular amplitude. Biophys J 64:581-593.
89. Thomas, DD, BJ Gaffney, and OH Griffith. 1993. Harden M. McConnell: the science speaks for itself. Biophys J 64:581-593.
88. Thomas, DD. 1993. Pollard to actomyosin: "Freeze! Don't even move your head". Biophys J 64:297-298.
87. Mahaney, JE, J Kleinschmidt, D Marsh, and DD Thomas. 1992. Effects of melittin on lipid-protein interactions in sarcoplasmic reticulum membranes. Biophys J 63:1513-1522.
86. Ostap, EM, T Yanagida, and DD Thomas. 1992. Orientational distribution of spin-labeled actin oriented by flow. Biophys J 63:966-975.
85. Alessi, DR, JET Corrie, PG Fajer, MA Ferenczi, DD Thomas, IP Trayer, and DR Trentham. 1992. Synthesis and properties of a conformationally restricted spin-labeled analog of ATP and its interaction with myosin and skeletal muscle. Biochemistry 31:8043-8054.
84. Lewis, SM, and DD Thomas. 1992. Resolved conformational states of spin-labeled Ca-ATPase during the enzymatic cycle. Biochemistry 31:7381-7389.
83. Tanner, JW, DD Thomas, and YE Goldman. 1992. Transients in orientation of a fluorescent cross-bridge probe following photolysis of caged nucleotides in skeletal muscle fibres. J Mol Biol 223:185-203.
82. Berger, CL, and DD Thomas. 1991. Rotational dynamics of actin-bound intermediates in the myosin ATPase cycle. Biochemistry 30:11036-11045.
81. Fajer, PG, EA Fajer, M Schoenberg, and DD Thomas. 1991. Orientational disorder and motion of weakly attached cross-bridges. Biophys J 60:642-649.
80. Lewis, SM, and DD Thomas. 1991. Microsecond rotational dynamics of spin-labeled Ca-ATPase during enzymatic cycling initiated by photolysis of caged ATP. Biochemistry 30:8331-8339.
79. Voss, J, W Birmachu, DM Hussey, and DD Thomas. 1991. Effects of melittin on molecular dynamics and Ca-ATPase activity in sarcoplasmic reticulum membranes: time-resolved optical anisotropy. Biochemistry 30:7498-7506.
78. Mahaney, JE, and DD Thomas. 1991. Effects of melittin on molecular dynamics and Ca-ATPase activity in sarcoplasmic reticulum membranes: electron paramagnetic resonance. Biochemistry 30:7171-7180.
77. Ostap, EM, and DD Thomas. 1991. Rotational dynamics of spin-labeled F-actin during activation of myosin S1 ATPase using caged ATP. Biophys J 59:1235-1241.
76. Harada, Y, K Sakurada, T Aoki, DD Thomas, and T Yanagida. 1990. Mechanochemical coupling in actomyosin energy transduction studied by in vitro movement assay. J Mol Biol 216:49-68.
75. Stein, RA, RD Ludescher, PS Dahlberg, PG Fajer, RLH Bennett, and DD Thomas. 1990. Time-resolved rotational dynamics of phosphorescent-labeled myosin heads in contracting muscle fibers. Biochemistry 29:10023-10031.
74. Fajer, PG, EA Fajer, and DD Thomas. 1990. Myosin heads have a broad orientational distribution during isometric muscle contraction: time-resolved EPR studies using caged ATP. Proc Natl Acad Sci U S A 87:5538-5542.
73. Fajer, PG, EA Fajer, JJ Matta, and DD Thomas. 1990. Effect of ADP on the orientation of spin-labeled myosin heads in muscle fibers: a high-resolution study with deuterated spin labels. Biochemistry 29:5865-5871.
72. Birmachu, W, and DD Thomas. 1990. Rotational dynamics of the Ca-ATPase in sarcoplasmic reticulum studied by time-resolved phosphorescence anisotropy. Biochemistry 29:3904-3914.
71. Fajer, PG, RLH Bennett, CF Polnaszek, EA Fajer, and DD Thomas. 1990. General method for multiparameter fitting of high-resolution EPR spectra using a simplex algorithm. J Magn Reson 88:111-125.
70. Lamche, HR, PT Silberstein, AC Knabe, DD Thomas, HS Jacob, and DE Hammerschmidt. 1990. Steroids decrease granulocyte membrane fluidity, while phorbol ester increases membrane fluidity studies using electron paramagnetic resonance. Inflammation 14:61-70.
69. Ervasti, JM, JR Mickelson, SM Lewis, DD Thomas, and CF Louis. 1989. An electron paramagnetic resonance study of skeletal muscle membrane fluidity in malignant hyperthermia. Biochim Biophys Acta 986:70-74.
68. Berger, CL, EC Svensson, and DD Thomas. 1989. Photolysis of a photolabile precursor of ATP (caged ATP) induces microsecond rotational motions of myosin heads bound to actin. Proc Natl Acad Sci U S A 86:8753-8757.
67. Squier, TC, and DD Thomas. 1989. Selective detection of the rotational dynamics of the protein-associated lipid hydrocarbon chains in sarcoplasmic reticulum membranes. Biophys J 56:735-748.
66. Leder, RO, SL Helgerson, and DD Thomas. 1989. The transverse location of the retinal chromophore in the purple membrane by diffusion-enhanced energy transfer. J Mol Biol 209:683-701.
65. Barnett, VA, and DD Thomas. 1989. Microsecond rotational motion of spin-labeled myosin heads during isometric muscle contraction saturation transfer electron paramagnetic resonance. Biophys J 56:517-523.
64. Birmachu, W, FL Nisswandt, and DD Thomas. 1989. Conformational transitions in the calcium adenosinetriphosphatase studied by time-resolved fluorescence resonance energy transfer. Biochemistry 28:3940-3947.
63. Squier, TC, DJ Bigelow, and DD Thomas. 1988. Lipid fluidity directly modulates the overall protein rotational mobility of the Ca-ATPase in sarcoplasmic reticulum. J Biol Chem 263:9178-9186.
62. Squier, TC, and DD Thomas. 1988. Relationship between protein rotational dynamics and phosphoenzyme decomposition in the sarcoplasmic reticulum Ca-ATPase. J Biol Chem 263:9171-9177.
61. Squier, TC, SE Hughes, and DD Thomas. 1988. Rotational dynamics and protein-protein interactions in the Ca-ATPase mechanism. J Biol Chem 263:9162-9170.
60. Fajer, PG, EA Fajer, NJ Brunsvold, and DD Thomas. 1988. Effects of AMPPNP on the orientation and rotational dynamics of spin-labeled muscle cross-bridges. Biophys J 53:513-524.
59. Ludescher, RD, and DD Thomas. 1988. Microsecond rotational dynamics of phosphorescent-labeled muscle cross-bridges. Biochemistry 27:3343-3351.
58. Thomas, DD, PG Fajer, EA Fajer, NJ Brunsvold, and EC Svensson. 1988. EPR evidence for nucleotide effects on attached cross-bridges. Adv Exp Med Biol 226:241-253.
57. Ludescher, RD, TM Eads, and DD Thomas. 1988. Ionic effects on the rotational dynamics of cross-bridges in myosin filaments, measured by triplet absorption anisotropy. J Mol Biol 200:89-99.
56. Strasburg, GM, M Hogan, W Birmachu, DD Thomas, and CF Louis. 1988. Site-specific derivatives of wheat germ calmodulin interactions with troponin and sarcoplasmic reticulum. J Biol Chem 263:542-548.
55. Thatte, HS, PB Addis, DD Thomas, DJ Bigelow, JR Mickelson, and CF Louis. 1987. Temperature-dependent abnormalities of the erythrocyte membrane in porcine malignant hyperthermia. Biochem Med Metab Biol 38:366-377.
54. Ludescher, RD, TM Eads, and DD Thomas. 1987. Triplet anisotropy studies of restricted rotational motion in myosin monomers and filaments.Optical Studies of Muscle Cross-Bridges. RJ Baskin and Y Yeh. CRC Press, Boca Raton, FL. 33-65.
53. Bigelow, DJ, and DD Thomas. 1987. Rotational dynamics of lipid and the Ca-ATPase in sarcoplasmic reticulum the molecular basis of activation by diethyl ether. J Biol Chem 262:13449-13456.
52. Thomas, DD. 1987. Detection of time-resolved microsecond molecular dynamics by optical and magnetic resonance spectroscopy. Structure, Dynamics, and Function of Biomolecules. A Ehrenberg, R Rigler, A Graslund and L Nilsson. Springer Verlag, Berlin, Germany. 140-144.
51. Barnett, VA, and DD Thomas. 1987. Resolution of conformational states of spin-labeled myosin during steady-state ATP hydrolysis. Biochemistry 26:314-323.
50. Thomas, DD. 1987. Spectroscopic probes of muscle cross-bridge rotation. Ann Rev Physiol 49:691-709.
49. Fajer, P, DD Thomas, JB Feix, and JS Hyde. 1986. Measurement of rotational molecular motion by time-resolved saturation transfer electron paramagnetic resonance. Biophys J 50:1195-1202.
48. Svensson, EC, and DD Thomas. 1986. ATP induces microsecond rotational motions of myosin heads crosslinked to actin. Biophys J 50:999-1002.
47. Lewis, SM, and DD Thomas. 1986. Effects of vanadate on the rotational dynamics of spin-labeled calcium adenosinetriphosphatase in sarcoplasmic reticulum membranes. Biochemistry 25:4615-4621.
46. Thomas, DD. 1986. Molecular dynamics resolved. Nature 321:539-540.
45. Sommerville, LE, RM Resnick, DD Thomas, and GL Nelsestuen. 1986. Terbium probe of calcium-binding sites on the prothrombin-membrane complex. J Biol Chem 261:6222-6229.
44. Squier, TC, and DD Thomas. 1986. Applications of new saturation transfer electron paramagnetic resonance methodology to the rotational dynamics of the Ca-ATPase in sarcoplasmic reticulum membranes. Biophys J 49:937-942.
43. Squier, TC, and DD Thomas. 1986. Methodology for increased precision in saturation transfer electron paramagnetic resonance studies of rotational dynamics. Biophys J 49:921-935.
42. Bigelow, DJ, TC Squier, and DD Thomas. 1986. Temperature dependence of rotational dynamics of protein and lipid in sarcoplasmic reticulum membranes. Biochemistry 25:194-202.
41. Barnett, VA, PG Fajer, CF Polnaszek, and DD Thomas. 1986. High-resolution detection of muscle crossbridge orientation by electron paramagnetic resonance. Biophys J 49:144-147.
40. Thomas, DD. 1986. Rotational diffusion of membrane proteins. Techniques for Analysis of Membrane Proteins. R Cherry and I Ragan. Chapman and Hall, London, England. 377-431.
39. Sommerville, LE, DD Thomas, and GL Nelsestuen. 1985. Tb3+ binding to bovine prothrombin and bovine prothrombin fragment 1. J Biol Chem 260:10444-10452.
38. Thomas, DD, TM Eads, VA Barnett, KM Lindahl, DA Momont, and TC Squier. 1985. Saturation transfer EPR and triplet anisotropy: complementary techniques for the study of microsecond rotational dynamics. Spectroscopy and the Dynamics of Biological Systems. PM Bayley and RE Dale. Academic Press, London, England. 239‑257.
37. Thomas, DD. 1985. Saturation transfer EPR studies of microsecond rotational motions in biological membranes. Enzymes of Biological Membranes. A Martonosi. Plenum Press, New York, NY. 287-312.
36. Cooke, R, MS Crowder, CH Wendt, VA Barnett, and DD Thomas. 1984. Muscle cross-bridges: do they rotate? Adv Exp Med Biol 170:413-427.
35. Thomas, DD, R Cooke, and VA Barnett. 1984. Comment on 'Geometrical constraints affecting crossbridge formation in insect flight muscle'. J Muscle Res Cell Motil 5:589-590.
34. Barnett, VA, and DD Thomas. 1984. Saturation transfer electron paramagnetic resonance of spin-labeled muscle fibers dependence of myosin head rotational motion on sarcomere length. J Mol Biol 179:83-102.
33. Eads, TM, DD Thomas, and RH Austin. 1984. Microsecond rotational motions of eosin-labeled myosin measured by time-resolved anisotropy of absorption and phosphorescence. J Mol Biol 179:55-81.
32. Thomas, DD, R Cooke, and VA Barnett. 1983. Orientation and rotational mobility of spin-labeled myosin heads in insect flight muscle in rigor. J Muscle Res Cell Motil 4:367-378.
31. Thomas, DD, CH Wendt, W Froncisz, and JS Hyde. 1983. Saturation transfer EPR spectroscopy on spin-labeled muscle fibers using a loop-gap resonator. Biophys J 43:131-135.
30. Thomas, DD. 1983. Rotational dynamics of spin-labeled muscle proteins. Ciba Found Symp 93:169-185.
29. Thomas, DD. 1982. Saturation transfer EPR studies of rotational dynamics in membranes. Membranes and Transport. A Martonosi. Plenum Press, New York, NY. 135-139.
28. Cooke, R, MS Crowder, and DD Thomas. 1982. Orientation of spin labels attached to cross-bridges in contracting muscle fibres. Nature 300:776-778.
27. Stryer, L, DD Thomas, and CF Meares. 1982. Diffusion-enhanced fluorescence energy transfer. Ann Rev Biophys Bioeng 11:203-222.
26. Stryer, L, DD Thomas, and WF Carlsen. 1982. Fluorescence energy transfer measurements of distances in rhodopsin and the purple membrane protein. Methods Enzymol 81:668-678.
25. Thomas, DD, and L Stryer. 1982. Transverse location of the retinal chromophore of rhodopsin in rod outer segment disc membranes. J Mol Biol 154:145-157.
24. Thomas, DD, DJ Bigelow, TC Squier, and C Hidalgo. 1982. Rotational dynamics of protein and boundary lipid in sarcoplasmic reticulum membrane. Biophys J 37:217-225.
23. Quintanilha, AT, DD Thomas, and MS Swanson. 1982. Protein-lipid interactions within purified and reconstituted cytochrome c reductase and oxidase. Biophys J 37:68-69.
22. Thomas, DD. 1981. Orientation and rotational dynamics of spin-labeled muscle crossbridges. Protein Dynamics and Energy Transduction. S Ishiwata. Taniguchi, Tokyo, Japan. 523‑542.
21. Hyde, JS, and DD Thomas. 1980. Saturation transfer spectroscopy. Ann Rev Phys Chem 31:293-317.
20. Thomas, DD, and R Cooke. 1980. Orientation of spin-labeled myosin heads in glycerinated muscle fibers. Biophys J 32:891-906.
19. Thomas, DD, S Ishiwata, JC Seidel, and J Gergely. 1980. Submillisecond rotational dynamics of spin-labeled myosin heads in myofibrils.Biophys J 32:873-889.
18. Swanson, MS, AT Quintanilha, and DD Thomas. 1980. Protein rotational mobility and lipid fluidity of purified and reconstituted cytochrome c oxidase. J Biol Chem 255:7494-7502.
17. Thomas, DD, JC Seidel, and J Gergely. 1979. Rotational dynamics of spin-labeled F-actin in the sub-millisecond time range. J Mol Biol 132:257-273.
16. Thomas, DD, WF Carlsen, and L Stryer. 1978. Fluorescence energy transfer in the rapid-diffusion limit. Proc Natl Acad Sci U S A 75:5746-5750.
15. Thomas, DD .1978. Large-scale rotational motions of proteins detected by electron paramagnetic resonance and fluorescence. Biophys J 24:439-462.
14. Thomas, DD, and C Hidalgo. 1978. Rotational motion of the sarcoplasmic reticulum Ca2+-ATPase. Proc Natl Acad Sci U S A 75:5488-5492.
13. Hidalgo, C, DD Thomas, and N Ikemoto. 1978. Effect of the lipid environment on protein motion and enzymatic activity of sarcoplasmic reticulum calcium ATPase. J Biol Chem 253:6879-6887.
12. Devaux, PF, A Baroin, A Bienvenue, E Favre, A Rousselet, and DD Thomas. 1977. Rotational diffusion of various membrane bound proteins as determined by saturation transfer EPR spectroscopy. Membrane Bioenergetics. L Packer, et al., editors. Academic Press, New York, NY. 47-54.
11. Hidalgo, C, and DD Thomas. 1977. Heterogeneity of SH groups in sarcoplasmic reticulum. Biochem Biophys Res Commun 78:1175-1182.
10. Baroin, A, DD Thomas, B Osborne, and PF Devaux. 1977. Saturation transfer electron paramagnetic resonance on membrane-bound proteins. I-Rotational diffusion of rhodopsin in the visual receptor membrane. Biochem Biophys Res Commun 78:442-447.
9. Thomas, DD. 1977. Saturation transfer EPR. Trends Biochem Sci 2:N62-N63.
8. Thomas, DD, JC Seidel, and J Gergely. 1976. Molecular motions and the mechanism of muscle contraction and its regulation. Contractile Systems in Nonmuscle Cells. SV Perry, et al., editors. Elsevier, Amsterdam, Netherlands. 13-21.
7. Thomas, DD, LR Dalton, and JS Hyde. 1976. Rotational diffusion studied by passage saturation transfer electron paramagnetic resonance. J Chem Phys 65:3006-3024.
6. Thomas, DD. 1975. Rotational dynamics in spin-labeled biomacromolecular assemblies: saturation transfer electron paramagnetic resonance. Ph. D. Thesis. Stanford University.
5. Thomas, DD, JC Seidel, J Gergely, and JS Hyde. 1975. The quantitative measurement of rotational motion of the subfragment-1 region of myosin by saturation transfer EPR spectroscopy. J Supramol Struct 3:376-390.
4. Thomas, DD, JC Seidel, JS Hyde, and J Gergely. 1975. Motion of subfragment-1 in myosin and its supramolecular complexes: saturation transfer electron paramagnetic resonance. Proc Natl Acad Sci U S A 72:1729-1733.
3. Thomas, DD, and HM McConnell. 1974. Calculation of paramagnetic resonance spectra sensitive to very slow rotational motion. Chem Phys Lett 25:470-475.
2. Hyde, JS, and DD Thomas. 1973. New EPR methods for the study of very slow motion: application to spin-labeled hemoglobin. Ann N Y Acad Sci 222:680-692.
1. Loew, GH, and DD Thomas. 1972. Molecular orbital calculations of the catalytic effect of lysozyme. I. Glu 35 as general acid catalyst. J Theor Biol 36:89-104.