MCDB&G Graduate Program Faculty
 
NameResearch focusContact
Adamala, KateWe are combining top-down and bottom-up approaches to synthetic biology; we use tools of protein engineering and molecular biology, together with novel synthetic cell technologies, to understand and modulate biological processes in complex systems.

kadamala@umn.edu

612-625-9066

Albert, FrankWe study the genetics of complex traits: how variation in genome sequences influences individual molecular, cellular and organismal features. We also seek to understand the evolutionary forces that shape genomic diversity.

falbert@umn.edu

612-301-1243

Alejandro, Emilyn

T2D is the most common chronic disease affecting human health, affecting more than 347 million individuals worldwide. T2D is a complex disease characterized by pancreatic β-cell failure to make sufficient amounts of insulin in the setting of obesity and insulin resistance in peripheral tissues. The risk for T2D is determined by many factors. Our genetic makeup can predispose us for T2D, and lifestyle can also reduce or exacerbate health risks. But in recent years, our studies and those of others have shown the importance of babies' time in the womb for influencing health over our lifespan. We and others have shown that poor uterine environments can increase the risk of many diseases in adulthood, including diabetes. Therefore, the long-term goal of the Alejandro Lab is to stop the vicious cycle of diabetes by launching a two-pronged research program for both intervention and prevention of this disease: 

  1. Research program in the pancreas to promote healthy β-cell: The role of OGT in pancreatic β-cell development and function 
  2. Research program in the placenta to identify modifiable risk factors for T2D: Role of placental nutrient sensor proteins in the developmental programming of pancreatic β-cell dysfunction and susceptibility to T2D.

ealejand@umn.edu

612-625-5149

Artinger, KristinThe Artinger lab focuses on the development of a population of cells called neural crest cells. Because these cells undergo multiple developmental processes to differentiate into craniofacial cartilage and peripheral nervous system among other derivatives, they represent an excellent model to study genetic and epigenetic regulation during development.

kartinge@umn.edu 

612-625-8577

Blazar, BruceTransplant immune responses/therapy and use of induced pluripotent stem cells

blaza001@umn.edu

612-626-2734

Cetera, MaureenWe investigate mechanisms that coordinate cell behaviors across great distances during tissue morphogenesis.

mcetera@umn.edu

612-301-2474

Chen, LihsiaCell adhesion, signal transduction, cytoskeleton, and C. elegans.

chenx260@umn.edu

612-625-1299

Clarke, DuncanYeast and Human Cell Cycle Control

clark140@umn.edu

612-624-3442

Conner, SeanClathrin-mediated endocytosis; mammalian intracellular membrane trafficking.

sdconner@umn.edu

612-625-3707

Courtemanche, NaomiStructure, assembly and dynamics of actin-based cytoskeletal network

ncourtem@umn.edu

612-624-3195

Davis, DanaC. albicans genetics and pathogenesis

dadavis@umn.edu

612-624-1912

Dehm, ScottFocuses on the role of the androgen receptor (AR) and alterations in AR signaling in prostate cancer development and progression

dehm@umn.edu

612-625-1504

Dong, XiaoWe focus on testing the mutation theory of aging: if accumulation of DNA mutations in normal somatic cells is a causal mechanism to age-related functional decline. We approach this by developing and applying state-of-the-art single-cell multi-omics technologies and machine learning algorithms.

dong0265@umn.edu

612-626-7090

Driscoll, MeghanThe Driscoll Lab investigates dynamic cancer and immune cell biology via quantitative microscopy, especially the development of computational analysis algorithms.drisc269@umn.edu
Engelhart, AaronThe research in the Engelhart laboratory is directed towards better understanding nucleic acid folding and function in order to advance two broad themes: 1) the development of novel nucleic acid-based imaging, analytical, and diagnostic technologies and 2) the elucidation of unanticipated roles for nucleic acids in vivo.

enge0213@umn.edu

612-625-1950

Ervasti, JamesMolecular Basis of Muscular Dystrophy; Role of Actin in Cell Polarity

jervasti@umn.edu

612-626-6517

Farrar, Michael Signal transduction and lymphocyte development

farra005@umn.edu

612-625-0401

Gammill, LauraCytoskeleton and Cell Motility, developmental mechanisms, neuroscience, and regulation of gene expression

gammi001@umn.edu

612-625-6158

Gardner, MelissaChromatin mechanics and dynamics; Quantitative fluorescence microscopy

klei0091@umn.edu

612-626-6760

Garry, DanielRegenerative medicine, cardiogenesis, and stem-cell biology.

garry@umn.edu

612-625-8988

Gill, MatthewWe are interested in discovering novel signaling pathways and mechanisms that affect development and aging in the nematode Caenorhabditis elegans using a combination of genetic, drug screening and biochemical approaches.  

gill0558@umn.edu

612-301-6314

Greenstein, DavidFundamental and fascinating developmental processes of meiosis and fertilization using C. elegans

green959@umn.edu

612-624-3955

Hackett, PerryTransposons, human gene therapy, vertebrate gene expression, mouse, zebrafish

hacke004@umn.edu

612-624-6736

Hays, ThomasCytoskeleton and cell motility, developmental mechanisms

haysx001@umn.edu

612-626-2949

Hogquist, Kristin Molecular mechanism of cell-fate determination in T cells

hogqu001@umn.edu

612-625-1616

Hsieh, PingHsunWe use genomics and population genetics modeling to study disease- and trait-relevant variants, including complex structural mutations, in humans.hsiehph@umn.edu
Igarashi, PeterKidney development, transcriptional regulation, microRNAs, primary cilia, polycystic kidney disease (PKD)

igarashi@umn.edu

612-625-3654

Isabella, AdamWe use zebrafish to study the genetic and cell biological basis by which neuronal connectivity is patterned during development and regeneration

aisabell@umn.edu

612-625-1602

Jameson, StephenDevelopment, homeostasis and trafficking of T lymphocytes

james024@umn.edu

612-625-1496

Junge, HaraldRetina, neurovascular interactions, wnt signaling

junge@umn.edu

612-624-6017

Kawakami, YasuhikoUnderstanding the molecular and genetic mechanisms of vertebrate limb development and apply the study to elucidate the mechanisms of congenital limb in human and limb regeneration

kawak005@umn.edu

612-626-9935

Kikyo, NobuakiNuclear reprogramming in somatic cell nuclear cloning and stem cells

kikyo001@umn.edu

612-624-0498

Kirkpatrick, DavidThe role of DNA repair and recombination in maintaining genome stability

dkirkpat@umn.edu

612-624-9244

Koepp, DeannaCell cycle regulation, Ubiquitination and proteolysis, Genetic mechanisms of tumorigenesis

koepp015@umn.edu

612-624-4201

Koob, MichaelGenome engineering, pioneering full gene and gene cluster replacement technologies; modeling the genetics of human disease in the mouse; molecular mechanism underlying Alzheimer’s Disease and Related Dementias, with a current focus on the phospho-dynamics of TAU

koobx001@umn.edu

612-626-4521

Kyba, MichaelStem Cell Biology: regulatory pathways, diseases and therapies Transcriptional control of mesoderm development

kyba@umn.edu

612-626-5869

Lange, CarolThe Lange lab studies how steroid hormone receptor (SR) positive and hormone-influenced cancers escape molecular targeted therapies. Signal transduction is an essential role of SRs. Indeed, all SRs can rapidly activate cytoplasmic protein kinases and act as “growth factor sensors”. In this role, SRs are heavily phosphorylated by mitogenic protein kinases (MAPKs, AKT, CDKs) that are frequently elevated and activated in SR+ (breast and reproductive tract) cancers. Phosphorylation of SRs alters their binding partners and promoter selection and influences cancer cell fate/plasticity by regulating genes that specify proliferative, pro-survival, metabolic, and cancer stem cell programs. Identifying the required kinases and co-activator partners of phospho-SRs will enable the targeting of multiple signaling molecules in addition to SRs, which is predicted to halt cancer metastasis, prevent recurrence, and increase patient survival. 

lange047@umn.edu

612-626-0621

Largaespada, DavidIdentification and understanding of genes involved in cancer development

larga002@umn.edu

612-626-4979

Low, WalterThe translational development of therapies for treating neurological disorders. 

lowwalt@umn.edu

612-626-9203

Mansky, KimFocus on signaling and transcriptional mechanisms that regulate osteoclast differentiation

kmansky@umn.edu

612-626-5582

Mansky, LouCell and molecular biology of HIV and HTLV

mansky@umn.edu

612-626-5525

McIvor, R ScottGene therapy for genetic disease and cancer using viral and non-viral vectors

mcivo001@umn.edu

612-626-1497

McLoon, LindaCraniofacial muscles in health and disease

mcloo001@umn.edu

612-626-0777

Moriarity, BrandenMy lab works on pediatric cancer genetics, immunotherapy, and gene therapy using cutting edge technologies, including DNA transposons, TALENs, and CRISPR/Cas9. 

mori0164@umn.edu

612-625-2226

Myers, ChadComputational biology and functional genomics - Machine learning for integrating diverse genomic data to make inferences about biological networks

cmyers@cs.umn.edu

612-624-8306

Nakagawa, YasushiMammalian brain development, cell type specification and establishment of neuronal connectivity

nakagawa@umn.edu

612-626-4916

Nakato, HiroshiMolecular and genetic analysis of Drosophila development

nakat003@umn.edu

612-625-1727

Neufeld, ThomasDevelopmental control of growth and cell proliferation in Drosophila

neufe003@umn.edu

612-625-5158

O'Connor, MichaelCell-cell interactions in growth, differentiation, and development

moconnor@umn.edu

612-626-0642

Perlingeiro, RitaMechanisms controlling lineage decision and reprogramming, and application to regenerative medicine

perli032@umn.edu

612-625-4984

Porter, MaryRegulation of dynein-based motility

porte001@umn.edu

612-626-1901

Rivera-Mulia, Juan CarlosResearch in the Rivera-Mulia lab focuses on understanding how DNA replication timing and large-scale chromosome organization are regulated and maintained in distinct cell types and remodeled during development as well as how alterations in nuclear architecture disrupt gene function in human disease.riveramj@umn.edu
Rougvie, AnnDevelopmental timing in C. elegans: from microRNAs to nutritional cues

rougv001@umn.edu

612-624-4708

Schmidt, DanielOur group invents and applies protein engineering technologies to study fundamental functional principles of natural and artificial living systems at a cellular level.

schmida@umn.edu

612-625-1180

Selmecki, AnnaWe employ diverse yeast model systems (Saccharomyces cerevisiae, Candida albicans, Candida auris, etc.) to understand how genome instability contributes to adaptation (eg. antifungal drug resistance) and determine the underlying mechanisms that promote genome instability.selmecki@umn.edu 
Shima, NaokoUses the laboratory mouse as a model to understand a causative link between chromosome instability and cancer

shima023@umn.edu

612-626-7830

Shimizu, YojiLymphocyte and tumor cell adhesion, migration and signal transduction

shimi002@umn.edu

612-626-6849

Sivaramakrishnan, Sivaraj (Shiv)Protein acrobatics - Study of protein function via protein engineering; Focus on cell signaling and motor proteins

sivaraj@umn.edu

612-301-1537

Skubitz, AmyDiscovery and validation of biomarkers for ovarian cancer

skubi002@umn.edu

612-625-5920

Somia, NikunjMy laboratory is interested in understanding the lifecycle of retroviruses and use this information 1) to identify new drug targets for HIV, 2) to develop better vectors for gene therapy and 3) to use these vectors for gene discovery.

somia001@umn.edu

612-625-6988

Song, GuishengMy research focuses mainly on the roles of microRNAs in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), obesity, insulin resistance and liver cancer, with the goal to develop novel therapeutic approaches for these disorders.

gsong@umn.edu

612-624-9961

Starr, TimUnderstanding the genetics of cancer in order to develop individualized, targeted therapies

star0044@umn.edu

612-626-6971

Titus, MargaretMolecular genetic analysis of unconventional myosin function

titus004@umn.edu

612-625-8498

Tolar, JakubStem cell gene therapy

tolar003@umn.edu

612-626-4949

Van Berlo, JopRole of cardiac progenitor cells in vivo during cardiac development

jvanberl@umn.edu

612-626-1853

Venteicher, AndrewWe seek to map the developmental origins of chordoma 1) to understand the epigenetic requirements that are necessary for malignant transformation in these challenging tumors, 2) to provide a framework to explain the variability in clinical behavior of chordoma, and 3) delineate vulnerabilities that may be used as new therapeutic targets.  We use a variety of epigenomics, single cell genomics, and biochemistry approaches to study the connection between notochordal development and human chordoma tumors.aventeic@umn.edu 
von Diezmann, LexyWe study how proteins self-organize and communicate information in living cells using single-molecule microscopy and genetic engineering. Our major focus is how crossover recombination is coordinated during meiosis in the model organism C. elegans.

lvondiez@umn.edu

612-624-8343

Voytas, DanielPlant genome engineering through homologous recombination; Retrotransposable elements and genome organization

voytas@umn.edu

612-626-4509

Yamamoto, MasatoCancer gene-therapy and virotherapy

yamam016@umn.edu

612-624-9131

Zaidi, ArslanOur research lies at the interface of population and quantitative genetics. We use theoretical and computational approaches to study the evolution and genetic basis of complex traits in humans.

aazaidi@umn.edu

612-626-3778