Research in my laboratory is concerned with the genes for the thrombospondin (TSP) proteins and the metaxin (MTX) proteins. The thrombospondins (TSP1-5) are extracellular proteins with roles in processes including angiogenesis, tumor growth, and skeletal development. The metaxins (MTX1 & 2) are mitochondrial membrane proteins that function in protein transport. Recent projects have involved sequencing cDNAs for thrombospondins 3 and 4 in zebrafish and a cDNA for a thrombospondin homologue in Drosophila. Another research focus has been to sequence cDNAs for a new metaxin protein (MTX3), not previously described, in zebrafish and Xenopus.
- Adolph, K.W. (2005). Characterization of the cDNA and amino acid sequences of Xenopus metaxin 3, and relationship to Xenopus metaxins 1 and 2. DNA Sequence.
- Adolph, K.W. (2004). The zebrafish metaxin 3 gene ( mtx3 ): cDNA and protein structure, and comparison to zebrafish metaxins 1 and 2. Gene 330 , 67-73 DNA Sequence.
- Adolph, K.W. (2002). The zebrafish thrombospondin 3 and 4 genes ( thbs3 and thbs4 ): cDNA and protein structure. DNA Sequence 13 , 277-285. DNA Sequence.
- Adolph, K.W. (2001). A thrombospondin homologue in Drosophila melanogaster: cDNA and protein structure. Gene 269 , 177-184.
- Adolph, K.W., and Bornstein, P. (1999). The human thrombospondin 3 gene: Analysis of transcription initiation and an alternatively spliced transcript. Mol. Cell Biol. Res. Commun. 2 , 47-52.